The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats

Dluzen, Dean E.; Muraoka, Shin‐ichiro; Engelmann, Mario; Landgraf, Rainer

doi:10.1016/s0196-9781(98)00047-3

Cited by 160 publications

(113 citation statements)

References 33 publications

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“…[14][15][16][17] Agonists and antagonists specific for the V1aR facilitate and inhibit, respectively, learning and memory in several paradigms, including social recognition. [14][15][16][17] We observed only a slight impairment in social recognition in the V1bRKO mice. Interestingly, oxytocin knockout mice are reported to show no social recognition (51).…”

Section: Discussionmentioning

confidence: 99%

“…12 Vasopressin also modulates social memory in rodents. [13][14][15][16] Administration of vasopressin V1a receptor (V1aR) agonists and antagonists affects both of these behaviors. 8,14,[17][18][19] Greater understanding of VP's and its receptors' functions in animal models may lead to improved clinical treatment for aggression.…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15][16] Administration of vasopressin V1a receptor (V1aR) agonists and antagonists affects both of these behaviors. 8,14,[17][18][19] Greater understanding of VP's and its receptors' functions in animal models may lead to improved clinical treatment for aggression. The recently cloned pituitary V1b receptor (V1bR; sometimes referred to as V3R) is also expressed in the brain, 20,21 suggesting a potential role in aggression and other behaviors.…”

Section: Introductionmentioning

confidence: 99%

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Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

et al. 2002

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Increased aggression is commonly associated with many neurological and psychiatric disorders. Current treatments are largely empirical and are often accompanied by severe side effects, underscoring the need for a better understanding of the neural bases of aggression. Vasopressin, acting through its 1a receptor subtype, is known to affect aggressive behaviors. The vasopressin 1b receptor (V1bR) is also expressed in the brain, but has received much less attention due to a lack of specific drugs. Here we report that mice without the V1bR exhibit markedly reduced aggression and modestly impaired social recognition. By contrast, they perform normally in all the other behaviors that we have examined, such as sexual behavior, suggesting that reduced aggression and social memory are not simply the result of a global deficit in sensorimotor function or motivation. Fos-mapping within chemosensory responsive regions suggests that the behavioral deficits in V1bR knockout mice are not due to defects in detection and transmission of chemosensory signals to the brain. We suggest that V1bR antagonists could prove useful for treating aggressive behavior seen, for example, in dementias and traumatic brain injuries. Molecular Psychiatry (2002) 7, 975-984.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

et al. 2002

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“…Hence, OT infusions into the cerebral ventricles enhance olfactory memory for conspecifics in rats. OT infusion directly into the OB enhances maternal care and increases both the frequency and the amplitude of spontaneous excitatory post-synaptic currents of granule cells (Yu et al 1996b) by both pre-and postsynaptic mechanisms, a process integral to olfactory recognition memory (Dluzen et al 1998(Dluzen et al , 2000Engelmann et al 1998;Osako et al 2001).…”

Section: Parental Bonds In Small-brained Mammalsmentioning

confidence: 99%

Mother–infant bonding and the evolution of mammalian social relationships

Broad

Curley

Keverne

2006

Phil. Trans. R. Soc. B

234

193

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A wide variety of maternal, social and sexual bonding strategies have been described across mammalian species, including humans. Many of the neural and hormonal mechanisms that underpin the formation and maintenance of these bonds demonstrate a considerable degree of evolutionary conservation across a representative range of these species. However, there is also a considerable degree of diversity in both the way these mechanisms are activated and in the behavioural responses that result. In the majority of small-brained mammals (including rodents), the formation of a maternal or partner preference bond requires individual recognition by olfactory cues, activation of neural mechanisms concerned with social reward by these cues and gender-specific hormonal priming for behavioural output. With the evolutionary increase of neocortex seen in monkeys and apes, there has been a corresponding increase in the complexity of social relationships and bonding strategies together with a significant redundancy in hormonal priming for motivated behaviour. Olfactory recognition and olfactory inputs to areas of the brain concerned with social reward are downregulated and recognition is based on integration of multimodal sensory cues requiring an expanded neocortex, particularly the association cortex. This emancipation from olfactory and hormonal determinants of bonding has been succeeded by the increased importance of social learning that is necessitated by living in a complex social world and, especially in humans, a world that is dominated by cultural inheritance.

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“…AVP infused into the OB enhanced social recognition in rats (Dluzen et al, 1998), and the local infusion of an AVP1R antagonist, small interfering RNA targeting of AVP1aR mRNA or the specific destruction of vasopressinergic cells in the OB impaired social recognition in rats (Tobin et al, 2010). Critically, the disruption of the vasopressinergic system in the OB did not affect object recognition or olfactory functions (Tobin et al, 2010).…”

Section: Neuropeptides Neurotransmitters and Social Recognitionmentioning

confidence: 95%

Social memories in rodents: Methods, mechanisms and modulation by stress

Kooij

Sandi

2012

Neuroscience & Biobehavioral Reviews

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a b s t r a c tIntact social memory forms the basis of meaningful interactions between individuals. Many factors can modulate the quality of social memory, and these have been studied in detail in rodents. Social memory, however, cannot be considered a single entity. The term social memory reflects different processes, such as social recognition of a novel conspecific individual and social learning (or 'learning from others'). This review summarizes the findings obtained with behavioral paradigms that were developed for the study of memory formation by social recognition and social learning. In particular, we focus on studies that include tests for social habituation/discrimination paradigms, tests for memory of a previously established social hierarchy and the social transmission of the food preference test. The role of individual differences and the main neurobiological mechanisms (i.e., the brain regions and neurochemical systems involved) that have been implicated in each of these types of social-related memories are reviewed. In addition, we address the key modulatory influence of stress on the formation of these types of memories; discussing the contribution of central (corticotropin-releasing factor, CRF) and peripheral (glucocorticoids) stress systems and their interactions with the social neuropeptide systems. Overall, we present here a general overview of the current state of a thriving research area within the field of social neuroscience.

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The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats

Cited by 160 publications

References 33 publications

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

Mother–infant bonding and the evolution of mammalian social relationships

Social memories in rodents: Methods, mechanisms and modulation by stress

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