The Effects of Ingested 20-Hydroxyecdysone on the Larvae of Aglais urticae, Inachis io, Cynthia cardui (Lepidoptera: Nymphalidae) and Tyria jacobaeae (Lepidoptera: Arctiidae)

Blackford, Michaela; Dinan, Laurence

doi:10.1016/s0022-1910(96)00112-6

Cited by 59 publications

(30 citation statements)

References 21 publications

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“…This is supported by the induction of moulting and developmental defects in certain species after ingestion of ecdysteroids and by the avoidance of ecdysteroid-treated food by other species. However, susceptibility and response varies between insect species, such that some would rather starve than consume food with even very low levels of 20E (e.g., Inachis io), others consume the food but suffer developmental defects (e.g., Aglais urticae), others can tolerate moderate levels, but not high ones (e.g., Tyria jacobaeae; Blackford and Dinan, 1997), while certain (widely polyphagous) species can feed and develop normally on food containing very elevated levels (800-1,000 ppm) of ecdysteroids (Dinan, 1998). Where ecdysteroids deter larval feeding and/or oviposition by adult female Lepidoptera, this is mediated by taste receptors on the mouth-parts or legs, respectively (Descoins and Marion-Poll, 1999;Marion-Poll and Descoins, 2002;Calas et al, 2006Calas et al, , 2007.…”

Section: Functions In Plantsmentioning

confidence: 99%

The Karlson Lecture. Phytoecdysteroids: What use are they?

Dinan

2009

Arch Insect Biochem Physiol

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Phytoecdysteroids are analogues of arthropod steroid hormones found in plants, where they deter predation by non-adapted predators. There is potential to exploit this to develop new strategies for pest control, either by using ecdysteroids as lead molecules for the design of novel pest control agents or by alteration of ecdysteroid levels/profiles in crop plants through plant breeding or genetic modification. However, it is other properties of phytoecdysteroids that have led to a rapid recent increase in scientific and commercial interest in these molecules. They are apparently non-toxic to mammals and a wide range of beneficial pharmacological (adaptogenic, anabolic, anti-diabetic, hepatoprotective, immunoprotective, wound-healing, and perhaps even anti-tumour) activities is claimed for them. In particular, this has led to a large (and unregulated) market for ecdysteroid-containing preparations for body-builders, sportsmen, and pets, among others. Ecdysteroids are also being considered as nutraceutical additives to food products. Further, ecdysteroids are good candidates as elicitors for gene-switch systems to be used in medical gene therapy and research applications. In this article, I review the applications of phytoecdysteroids and assess their future potential.

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Section: Functions In Plantsmentioning

confidence: 99%

The Karlson Lecture. Phytoecdysteroids: What use are they?

Dinan

2009

Arch Insect Biochem Physiol

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“…The potential ecological importance of 20E may be illustrated by several observations: (i) 20E deters oviposition and larval feeding (Calas et al, 2006); (ii) monophagous or oligophagous species feeding on host plants containing exogenous 20E were either deterred from feeding or showed abnormalities in growth and development (Blackford and Dinan, 1997); (iii) during sexual activity of the spider Tegenaria atrica 20E inhibits cannibalism and changes sex pheromone production (Trabalon et al, 2005); (iv) anomalous molting, immobility, reduced invasion, impaired development, and death were observed in nematodes exposed to 20E (Soriano et al, 2004);and, (v) 20E concentration increases in response to mechanical damage (Schmelz et al, 1998), insect herbivory (Schmelz et al, 1999), and application of methyl jasmonate (Schmelz et al, 1999). These findings suggest that the induction of PEs may protect plants from insect attack (Schmelz et al, 2002).…”

Section: ��mentioning

confidence: 99%

Level and distribution of 20-hydroxyecdysone during Pfaffia glomerata development

Festucci-Buselli

Contim

Barbosa

et al. 2008

Braz. J. Plant Physiol.

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The ecdysteroid 20-hydroxyecdysone (20E) is a steroid hormone found in insects and few plants. To analyze its temporal and spatial distribution in Pfaffia glomerata (Amaranthaceae), we selected among 71 accessions, the accession 13 which showed the highest root 20E total quantity (1.48 g/plant root). The 20E was constantly detected in flowers, leaves, stems, and roots, but its percentage was variable throughout its development. The highest 20E percentage was found in flowers (0.82%), roots (0.66%), leaves (0.60%), and stems (0.24%). While stems showed the least variable 20E percentage (0.13% -0.24%), followed by roots (0.42% -0.66%), and flowers (0.47% -0.82%). Leaves showed the greatest 20E percentage variation (0.21% -0.60%). The stem and leaves 20E total amount remained constant, showing a little variation while root 20E total amount increased over time, suggesting that 20E may be accumulated in roots. These findings suggest that 20E has tissue specific functions in plant and may have ecological significance since uncoordinated pulses of 20E are often lethal to insects.

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“…Phytoecdysteroids are polyhydroxylated steroids, structurally related to insect molting hormones, that have been implicated in plant defense by deterring insect herbivory, delaying insect development and causing lethality to insect larvae (Arnault & Slama, 1986; Blackford & Dinan, 1997; Marion-Poll & Descoins, 2002; Rharrabe, Sayan, & Lafont, 2010; Singh & Russell, 1980). Phytoecdysteroids have also shown a wide range of therapeutic effects in mammals, including anabolic, performance enhancing (Gorelick-Feldman, MacLean, Ilic, Poulev, Lila, Cheng, & Raskin, 2008; Slama & Lafont, 1995), anti-osteoporotic (Kapur, Wuttke, Jarry, & Seidlova-Wuttke, 2010; Seidlova-Wuttke, Christel, Kapur, Nguyen, Jarry, & Wuttke, 2010) and wound healing properties (Syrov & Khushbaktova, 1996).…”

Section: Introductionmentioning

confidence: 99%

Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties

et al. 2014

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Quinoa (Chenopodium quinoa Willd.) contains high levels of biologically active phytoecdysteroids, which have been implicated in plant defense from insects, and have shown a range of beneficial pharmacological effects in mammals. We demonstrated that the most prevalent phytoecdysteroid, 20-hydroxyecdysone (20HE), was secreted (leached) from intact quinoa seeds into water during the initial stages of seed germination. Leaching efficiency was optimized by ethanol concentration (70% ethanol), temperature (80°C), time (4 h), and solvent ratio (5 ml/g seed). When compared to extraction of macerated seeds, the leaching procedure released essentially all the 20HE available in the seeds (491 μg/g seed). The optimized quinoa leachate (QL), containing 0.86% 20HE, 1.00% total phytoecdysteroids, 2.59% flavonoid glycosides, 11.9% oil, and 20.4% protein, significantly lowered fasting blood glucose in obese, hyperglycemic mice. Leaching effectively releases and concentrates bioactive phytochemicals from quinoa seeds, providing an efficient means to produce a food-grade mixture that may be useful for anti-diabetic applications.

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The Effects of Ingested 20-Hydroxyecdysone on the Larvae of Aglais urticae, Inachis io, Cynthia cardui (Lepidoptera: Nymphalidae) and Tyria jacobaeae (Lepidoptera: Arctiidae)

Cited by 59 publications

References 21 publications

The Karlson Lecture. Phytoecdysteroids: What use are they?

The Karlson Lecture. Phytoecdysteroids: What use are they?

Level and distribution of 20-hydroxyecdysone during Pfaffia glomerata development

Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties

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