The Effects of Inhalation of Helium Mixed With Oxygen on the Mechanics of Respiration 1

Barach, Alvan L.; Eckman, Morris

doi:10.1172/jci100758

Cited by 54 publications

(26 citation statements)

References 5 publications

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“…In 1934, Barach was first to propose using Heliox as a therapeutic gas (Barach, 1934). Since a helium/oxygen mixture (79/21) has a weight that is one-third compared with air, Barach proposed using this lighter gas to improve the flow of oxygen in patients with upper airway obstruction and asthma exacerbation (Barach, 1935;Barach, 1936). The high thermal conductivity of helium results in lower body temperature when the body is embedded in helium, which could result in decreased metabolism and decreased energy expenditure (Singer, 2007).…”

Section: Application Of Helium In Heliox (80%: 20%/helium: Oxygen)mentioning

confidence: 99%

A Review on the Real Life Applications of Helium

Chhandak¹,

Israni²,

Trivedi³

2017

Int.J.Curr.Microbiol.App.Sci

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Section: Application Of Helium In Heliox (80%: 20%/helium: Oxygen)mentioning

confidence: 99%

A Review on the Real Life Applications of Helium

Chhandak¹,

Israni²,

Trivedi³

2017

Int.J.Curr.Microbiol.App.Sci

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“…In 1936 he noted that "Oxygen therapy in suitable cases relieves difficult breathing, restores strength, and helps reduce the swelling of the patient's legs and back". 11 He went on to design and use the first portable oxygen devices for patients with emphysema. In the 1950s he used transfilled oxygen bottles for ambulatory patients with exertional dyspnea.…”

Section: Application Of Oxygen In Medicinementioning

confidence: 99%

The Story of Oxygen

Heffner

2012

Respir Care

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The history of oxygen from discovery to clinical application for patients with chronic lung disease represents a long and storied journey. Within a relatively short period, early investigators not only discovered oxygen but also recognized its importance to life and its role in respiration. The application of oxygen to chronic lung disease, however, took several centuries. In the modern era, physiologists pursued the chemical nature of oxygen and its physiologic interaction with cellular metabolism and gas transport. It took brazen clinicians, however, to pursue oxygen as a therapeutic resource for patients with chronic lung disease because of the concern in the 20th century of the risks of oxygen toxicity. Application of ambulatory oxygen devices allowed landmark investigations of the long-term effects of continuous oxygen that established its safety and efficacy. Although now well established for hypoxic patients, many questions remain regarding the benefits of oxygen for varying severity and types of chronic lung disease.

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“…1,2 Since then, clinical applications have included various pathologic conditions involving both the upper and lower airways. 3 In the majority of clinical scenarios, a helium-oxygen gas mixture is delivered via a face mask or through a standard intensive care unit (ICU) ventilator.…”

Section: Introductionmentioning

confidence: 99%

Helium insufflation with sevoflurane general anesthesia and spontaneous ventilation during airway surgery

Tobias

2009

Can J Anesth/J Can Anesth

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Purpose The therapeutic benefits and clinical applications of helium-oxygen gas mixtures were first reported over 70 years ago. Since then, helium has been used in the treatment of obstructive processes of both the upper and lower airways. We report a unique case regarding helium insufflation with sevoflurane anesthesia and spontaneous ventilation for airway surgery. Clinical features A helium-oxygen mixture was administered during airway surgery in an 8-year-old boy with obstruction of the upper airway. Following the introduction of a helium-oxygen mixture during general anesthesia with spontaneous ventilation, a relatively rapid improvement in the patient's respiratory status was observed with a decrease in the audible inspiratory stridor, improved gas exchange, decreased respiratory rate, decreased suprasternal/intercostal retractions, and a decrease in the transcutaneous CO 2 . The physiologic basis for helium's effects on gas exchange are discussed and its use during insufflation for upper airway surgery is reviewed. Conclusions The addition of helium improves gas exchange with spontaneous ventilation during general anesthesia for airway surgery. RésuméObjectif Les bienfaits the´rapeutiques et les applications cliniques des me´langes gazeux he´lium-oxyge`ne ont e´te´r apporte´s pour la premie`re fois il y a plus de 70 ans. Depuis, l'he´lium a e´te´utilise´dans le traitement de syndromes obstructifs des voies ae´riennes supe´rieures et infe´rieures. Nous rapportons ici un cas unique en ce qui touche a`l'insufflation d'he´lium lors d'une anesthe´sie au se´voflurance en ventilation spontane´e lors d'une chirurgie des voies ae´riennes. É léments Cliniques Un me´lange he´lium-oxyge`ne a e´teá dministre´pendant une chirurgie des voies ae´riennes re´alise´e chez un enfant de huit ans manifestant une obstruction des voies ae´riennes supe´rieures. Apre`s l'introduction d'un me´lange he´lium-oxyge`ne pendant l'anesthe´sie ge´ne´rale avec ventilation spontane´e, une ame´lioration relativement rapide de l'e´tat respiratoire du patient a e´te´observe´e avec une diminution du stridor audible, un e´change gazeux ame´liore´, une fre´quence respiratoire re´duite, un tirage suprasternal/intercostal moindre et une re´duction du CO 2 transcutane´. Le fondement physiologique des effets de l'he´lium sur les e´changes gazeux est discute´et son utilisation pendant l'insufflation lors de chirurgie des voies ae´riennes supe´rieures est passe´e en revue. Conclusion L'ajout d'he´lium ame´liore les e´changes gazeux en ventilation spontane´e pendant l'anesthe´sie ge´ne´rale lors de chirurgies des voies ae´riennes.

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The Effects of Inhalation of Helium Mixed With Oxygen on the Mechanics of Respiration 1

Cited by 54 publications

References 5 publications

A Review on the Real Life Applications of Helium

A Review on the Real Life Applications of Helium

The Story of Oxygen

Helium insufflation with sevoflurane general anesthesia and spontaneous ventilation during airway surgery

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