The effects of inhaled beclomethasone dipropionate (Becotide) and sodium cromoglycate on asthmatic reactions to provocation tests

Abstract

A comparison was made between the eflFects of prior inhalation of sodium cromoglycate or beclomethasone dipropionate on immediate, late and dual asthmatic reactions to provocation challenge tests with a range of allergcnii. Whereas sodium cromoglycate inhibited immediate and dual asthmatic reactions, beclomethasone dipropionate had no elTect on immediate asthmatic reactions, but consistently inhibited late asthmatic reactions.

The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti‐inflammatory therapies

“…When used in single dose shortly before allergen challenge (or in the interval phase between the EAR and the LAR; 89), ICSs demonstrate no effect on the EAR with marked inhibition of the LAR (45,69,75,90). Prolonged treatment improves the EAR (91)(92)(93)(94) and probably has a greater effect on the late inflammatory sequelae.…”

“…The cromones, sodium cromoglycate, and nedocromil, when used before, but not after, allergen challenge inhibit the entire response including induced AHR (40,43,45,69,95). There are no studies addressing airway inflammation.…”

“…Understanding of the classic biphasic nature of the allergen response, namely the EAR with spontaneous resolution followed by a LAR, became obvious over the next decade (38). By the late 1960s and early 1970s, despite important differences in opinions regarding immunopathogenesis, Professor Orie and his colleagues in the Netherlands (39)(40)(41)(42) and Professor Pepys and colleagues in the United Kingdom (43)(44)(45)(46) used this dual asthmatic response model to investigate the pathogenesis of asthma and study the effects of asthma therapy.…”

Challenge inhalation tests in the diagnosis of occupational asthma: the guidelines of European Respiratory Society

“…Желательно также отменить ингаляционные глюко кортикостероиды (иГКС). В исследованиях показа но, что при воздействии ингаляционных и перораль ных кортикостероидов в дозозависимом режиме значительно ослабляются бронхиальная реакция на аллергены, особенно поздняя, и связанная с ней НБГр, хотя и не подавляется полностью реакция бронхов [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]. Протективный эффект иГКС при аллерген индуцированной ранней реакции, эозино филия дыхательных путей и повышение НБГр час тично или полностью сохраняются в течение 12 ч после прекращения терапии [48].…”

Jack Pepys' contributions to the medical literature

“…He described varying 18 time courses of reactions to these inhalation challenges including immediate, isolated nonimmediate, dual immediate and late, and recurrent nocturnal asthma, 3 and often as well the protective effects of disodium cromoglycate and/or beclomethasone on these reactions. 15 Among the occupational causes of asthma that he documented using this approach, some were administered as aerosols such as the enzymes of B subtilis, 13 the urinary proteins of rats and mice, 16 and water from a contaminated factory humidifier. 17 Most often, the suspected agent was mixed in increasing amounts with lactose, which the patient poured back and forth from one tray to another (Figs 1 and 2).…”