“…All the included trials provided the data needed for the comparisons (mean and SD); the intensity of pain was measured using VAS in 14 trials, 11,52,53,56,61,62,65,68,71,73,74,77,78,80 whereas 5 trials used NRS. 48,57,60,63,79 For homogeneity, the analyzed trials were subgrouped into four categories: (1) those that compared IFC alone to placebo intervention 56,63 ; (2) trials comparing IFC plus other interventions versus placebo plus other interventions 11,48,57 ; (3) trials comparing two parallel interventions, one of which was IFC 52,62,65,68,74,77 ; and (4) trials investigating the effect of adding IFC to a standard treatment versus the standard treatment alone.…”