The Effects of Internal Mammary Artery Implantation on Cardiac Function and Survival Following Acut Coronary Artery Occlusion

Reis, Robert L.; Enright, Lee P.; Staroscik, Rudolf N.; Hannah, rd H

doi:10.1097/00000658-197001000-00002

Cited by 13 publications

(2 citation statements)

References 6 publications

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“…Thirty-four foxhounds of either sex, age [7][8][9][10][11][12][13][14][15][16][17][18] months, weight kg, were used for the studies. Twenty-three animals made up the IMA implanted group (group 1), and eleven dogs constituted the no IMA implanted group (group 2).…”

Section: Animalsmentioning

confidence: 99%

“…Vials were vortex agitated for 3 minutes, and approximately 1 million microspheres in a volume of 0.4-0.7 ml were diluted with saline to a volume of 2 ml and injected into the left atrial appendage over a 5-10-second period, followed by a 10-ml saline flush. Arterial occlusions were performed 15 After all microsphere blood flow measurements were completed, a square-wave electromagnetic flow probe (model 501, Carolina Medical Electronics, Inc., King, N.C.) was applied to the IMA just proximal to the heart. Basal IMA blood flow was determined after the adenosine infusion was stopped and the heart rate and blood pressure had returned to baseline.…”

Section: Final Studymentioning

confidence: 99%

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Creation of anastomoses between an extracardiac artery and the coronary circulation. Proof that myocardial angiogenesis occurs and can provide nutritional blood flow to the myocardium.

1990

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The purpose of this investigation was to determine whether blood vessels could develop de novo between an extracardiac artery and a collateral-dependent zone of the heart and to quantify the nutritive blood flow afforded by the new vessels. We also adapted the preparation so that angiogenically active agents could be chronically administered directly to the site of neovascularization in subsequent studies. To induce neovascularization between a systemic artery and the coronary circulation, the left internal mammary artery (IMA) was implanted in an intramyocardial tunnel in proximity to the left anterior descending coronary artery (LAD). A tube situated in the distal IMA connected to an implanted pump provided for continuous intra-arterial infusion at the site of angiogenesis. During the same procedure, an ameroid constrictor was placed on the proximal LAD, rendering its perfusion territory collateral dependent during a 2-3 week period. After 8 weeks, the functional capacity of the anastomoses established between the implanted IMA and the LAD territory was assessed by determining regional myocardial blood flow under basal conditions, during adenosine-induced vasodilatation, and during differential occlusions of the IMA and left circumflex coronary artery (LCCA). For all dogs, IMA occlusion decreased maximal LAD territory flow from 1.31+0.11 to 1.16±0.10 ml/min/g (p

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Section: Animalsmentioning

confidence: 99%

Section: Final Studymentioning

confidence: 99%

Creation of anastomoses between an extracardiac artery and the coronary circulation. Proof that myocardial angiogenesis occurs and can provide nutritional blood flow to the myocardium.

1990

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The Vineberg Procedure in the Era of Transmyocardial Revascularization

Tsang

Chiu

1999

Developments in Cardiovascular Medicine

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Blood flow capacity via direct acute myocardial revascularization

Kohmoto

Uzun

et al. 1997

Basic Res Cardiol

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The concept of direct myocardial revascularization, achieving myocardial perfusion through means other than the normal coronary vasculature, has a long history with the most widely investigated technique being the Vineberg procedure; current interest centers around the encouraging preliminary clinical results obtained with transmyocardial laser revascularization. Despite significant previous research, the acute blood flow potential through the direct myocardial route remains unknown. Nontransmural laser channels were made in the distal LAD territory from the epicardial surface of 5 mongrel dogs to which an internal mammary artery was connected. A flow probe was placed on the distal most portion of the artery and an intercostal branch was cannulated for infusion of colored microspheres. Measurements were taken under baseline conditions and following LAD and epicardial collateral ligation. Under all conditions, blood flow pattern was of a to-and-fro nature. At baseline, there was an average 0.60 +/- 0.24 ml/min net flow into the myocardium which was all contained within 0.5 cm of the central channel with a final myocardial perfusion of 0.011 +/- 0.016 ml/min/g. Following induction of ischemia average flow increased to 1.41 +/- 0.51 ml/min which extended as far as 1 cm from the channel with a final myocardial perfusion of 0.22 +/- 0.19 ml/min/g. In conclusion, a limited amount of acute myocardial perfusion can be achieved by the present technique of direct myocardial revascularization and the amount of flow is highly dependent upon the amount of flow through the native circulation.

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The Effects of Internal Mammary Artery Implantation on Cardiac Function and Survival Following Acut Coronary Artery Occlusion

Cited by 13 publications

References 6 publications

Creation of anastomoses between an extracardiac artery and the coronary circulation. Proof that myocardial angiogenesis occurs and can provide nutritional blood flow to the myocardium.

Creation of anastomoses between an extracardiac artery and the coronary circulation. Proof that myocardial angiogenesis occurs and can provide nutritional blood flow to the myocardium.

The Vineberg Procedure in the Era of Transmyocardial Revascularization

Blood flow capacity via direct acute myocardial revascularization

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