The Effects of Intrahippocampal Grafts, Training, and Postoperative Housing on Behavioral Recovery After Septohippocampal Damage in the Rat

Kelche, Christian; Roeser, Caroline; Jeltsch, Hélène; Cassel, J.C.; Will, Bruno

doi:10.1006/nlme.1995.1016

Cited by 29 publications

(7 citation statements)

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“…Reduced thalamic atrophy occurred after brain infarction only when neocortical transplants were combined with an enriched environment, and no effect was seen with the transplant or enrichment alone (76). There was a similar finding where only the combination of cell suspensions and enrichment was effective in aspirative brain lesions but not in either intervention alone (77,78). In other studies, enrichment worked as well as the grafts (46) or caused better survival of grafted cells (79).…”

Section: Discussionmentioning

confidence: 67%

Functional Recovery in Rats With Chronic Spinal Cord Injuries After Exposure to an Enriched Environment

Fischer

Péduzzi

2007

The Journal of Spinal Cord Medicine

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Background/Objective: The objective of this study was to determine the effect of environmental enrichment on the sensorimotor function of rats with chronic spinal cord injuries.Design: Adult Sprague-Dawley rats received a contusive injury of moderate severity at vertebral level T8 using a weight-drop device. Three months after injury, 1 randomized group (n ¼ 16) of rats was placed in an enriched environment, whereas the control group (n ¼ 16) remained housed in standard laboratory cages (2/cage).Methods: Animals were placed in an enriched environment for 4 weeks beginning at 3 months after injury. The enriched environment consisted of a large cage (5-6 rats/cage) with access to items such as tubes, ramps, and running wheel, with items changed daily.Main Outcome Measures: Functional evaluation consisted of the open field Basso, Beattie and Bresnahan (BBB) locomotor test and the tests that form the combined behavioral score (CBS). The CBS includes motor score, toe spread, placing, withdrawal, righting, inclined plane, hot plate, and swim tests. Behavioral testing was repeated 7 times before and after the period of intervention.Results: The group placed in the enriched environment scored significantly better on the BBB (ANOVA repeated-measures, P , 0.01) test and CBS (ANOVA repeated-measures, P , 0.01).Conclusions: Environmental enrichment results in significant functional improvement in animals with spinal cord injury even with a substantial delay in initiating treatment after injury. The features of an enriched environment that may be responsible for the improvement include social interactions, exercise, and novel items in an interesting environment. These findings suggest a continued plasticity of the chronically injured rat spinal cord and a possible therapeutic intervention for people with spinal cord injury. Spinal Cord Med. 2007;30:147-155 J

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Section: Discussionmentioning

confidence: 67%

Functional Recovery in Rats With Chronic Spinal Cord Injuries After Exposure to an Enriched Environment

Fischer

Péduzzi

2007

The Journal of Spinal Cord Medicine

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“…Similar conclusions were drawn more recently from an experiment in which the behavioral effects of postsurgical training combined to intrahippocampal cell suspension grafts were assessed. Actually, Kelche et al (1995) found the post-surgical training to interact positively with the grafts, but only at the level of behavioral performance. Again, the graft-induced AChE-positive reinnervation pattern did not differ between the rats which had sustained training and those which had not.…”

Section: Grafts Rich In Cholinergic Neuronsmentioning

confidence: 99%

The Fimbria-Fornix/Cingular Bundle Pathways: A Review of Neurochemical and Behavioural Approaches Using Lesions and Transplantation Techniques

Cassel

Duconseille

Jeltsch

et al. 1997

Progress in Neurobiology

104

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“…Under some conditions, neither the enriched experience nor the transplant alone had a beneficial effect but the combination of the two treatments yielded significant improvement in learning. Further work indicates that formal training of rats may be more effective than enriched environment in promoting the effects of brain cell grafts on recovery of learning ability (Kelche et al 1995). The results of such animal research may someday benefit human patients.…”

Section: Applications To Recovery From or Compensation For Brain Damagementioning

confidence: 99%

Aspects of the Search for Neural Mechanisms of Memory

Rosenzweig

1996

Annu. Rev. Psychol.

102

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The search for neural mechanisms of memory has been under way for more than a century. The pace quickened in the 1960s when investigators found that training or differential experience leads to significant changes in brain neurochemistry, anatomy, and electrophysiology. Many steps have now been identified in the neurochemical cascade that starts with neural stimulation and ends with encoding information in long-term memory. Applications of research in this field are being made to child development, successful aging, recovery from brain damage, and animal welfare. Extensions of current research and exciting new techniques promise novel insights into mechanisms of memory in the decades ahead. CONTENTS

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The Effects of Intrahippocampal Grafts, Training, and Postoperative Housing on Behavioral Recovery After Septohippocampal Damage in the Rat

Cited by 29 publications

References 0 publications

Functional Recovery in Rats With Chronic Spinal Cord Injuries After Exposure to an Enriched Environment

Functional Recovery in Rats With Chronic Spinal Cord Injuries After Exposure to an Enriched Environment

The Fimbria-Fornix/Cingular Bundle Pathways: A Review of Neurochemical and Behavioural Approaches Using Lesions and Transplantation Techniques

Aspects of the Search for Neural Mechanisms of Memory

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