The effects of intramyometrial injection of prostaglandin F2α on severe post-partum hemorrhage

Takagi, Shigeo; Yoshida, Takao; Togo, Yoshichika; Tochigi, Hidemaro; Abe, Makoto; Sakata, Hisae; Fujii, Torao; Takahashi, Hideki; Tochigi, Buichi

doi:10.1016/0090-6980(76)90037-x

Cited by 75 publications

(6 citation statements)

References 4 publications

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“…Despite clinically for treatment of post partum hemorrhage (73,135,141). In agreement with these clinical studies intravenous infusion of PGF2a was found to induce a markedly increased myometrial contractile activity (VII), without signs of uterine tachyphylaxia to the hormone during 1 % hours of infusion.…”

Section: A D a Obstet Gynecol Scand Suppl121mentioning

confidence: 99%

Calcium entry blockade as a therapeutic principle in the female urogenital tract

Forman

1984

Acta Obstet Gynecol Scand

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Section: A D a Obstet Gynecol Scand Suppl121mentioning

confidence: 99%

Calcium entry blockade as a therapeutic principle in the female urogenital tract

Forman

1984

Acta Obstet Gynecol Scand

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“…Also muscle contractions have been shown to increase NO formation in incubated rat skeletal muscle preparations [9] as well as in human skeletal muscle interstitium [10]. It could therefore be speculated that during NOS inhibition, other vasodilators formed in human skeletal muscle such as adenosine [11, 12, 13], prostacyclin (PGI 2 ) [14, 15, 16, 17] or potassium (K + ) [18, 19]are produced or released to a greater extent in response to contraction, thereby compensating for diminished NO levels. In this regard, adenosine has been shown to play a compensatory role in the regulation of coronary blood flow in dogs with chronic inhibition of NO synthesis [20].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Nitric Oxide Synthesis by Systemic N<sup>G</sup>-Monomethyl-<i>L</i>-Arginine Administration in Humans: Effects on Interstitial Adenosine, Prostacyclin and Potassium Concentrations in Resting and Contracting Skeletal Muscle

Bangsbo¹,

Langberg²,

Saltin³

et al. 2000

J Vasc Res

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We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI₂) and potassium (K⁺) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N^G-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p < 0.05) from 0.11 ± 0.03 μmol/l at rest to 0.48 ± 0.06 μmol/l during exercise. Interstitial adenosine during exercise in L-NAME was similar (p > 0.05) to controls. The 6-keto-prostaglandin F1α concentration in controls was 1.17 ± 0.20 ng/ml at rest and increased (p < 0.05) to 1.97 ± 0.30 ng/ml during exercise and was further elevated (p < 0.05) to 2.76 ± 0.38 ng/ml after exercise and these concentrations were not different (p > 0.05) in L-NAME. The interstitial K⁺ concentration in controls increased (p < 0.05) from 4.1 ± 0.1 mmol/l at rest to 9.5 ± 0.5 mmol/l during exercise. The interstitial K⁺ concentration during exercise (6.7 ± 0.4 mmol/l) was lower (p < 0.05) in L-NAME than in controls. The present findings demonstrate that the muscle interstitial concentrations of adenosine, PGI₂ and K⁺ during exercise are not increased with systemic NOS inhibition. Thus, the lack of effect of NOS inhibition on the rate of blood flow to contracting human skeletal muscle does not appear to be due to compensatory formation or release of adenosine, PGI₂ and K⁺ in the muscle interstitium. The present study also supports a role for PGI₂ in the regulation of blood flow during exercise.

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“…Furthermore, the associated immense increase in maximal PGF 2␣ -induced contractility at this point of reproduction suggests a particular role in controlling postpartum hemorrhage as shown by Takagi et al [49]. Metabolites of PGF 2␣ are low postpartum [50], and thus the forceful contractile ability may reflect sensitization of the myometrium to PGF 2␣ as opposed to the circumstance during labor.…”

Section: Discussionmentioning

confidence: 92%

Effect of Oxytocin Receptor Blockade on Rat Myometrial Responsiveness to Prostaglandin F2α1

Engstrøm

Bratholm

Christensen

et al. 2000

Biology of Reproduction

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In the present study we have shown that the genetic expression of prostaglandin (PG)F(2alpha) receptor (R) and cyclooxygenase (COX)-2 increases in laboring rat myometrium. This finding was associated with a relatively weak contractile in vitro response (E:(max)) of isolated uterine strips when challenged with PGF(2alpha). Five days postpartum PGF(2alpha)-R mRNA values exceeded those during labor while COX-2 mRNA was reduced to preparturient values. Maximal contractility of isolated strips stimulated with PGF(2alpha) at this time was enhanced and E:C(50) decreased. Oxytocin treatment of estrogen-primed nonpregnant rats down-regulated uterine contractile responsiveness to PGF(2alpha), leaving mRNA values for this receptor unchanged, whereas oxytocin receptor blockade with atosiban (an oxytocin receptor antagonist) left E:(max) unaltered. In contrast, atosiban treatment of pregnant rats resulted in a 2.5-fold increase in E:(max) and a considerably reduced EC(50) during labor when compared to untreated delivering rats. The increased contractile ability was associated with a threefold increase in PGF(2alpha)-R mRNA production, indicating that the regulation by atosiban of the PGF(2alpha)-induced response is exerted at the genetic level. Based on the present data we suggest that 1) PGF(2alpha)-R stimulation may not primarily exert a contracting role in the normally delivering myometrium, and 2) the presence of the PGF(2alpha)-R system in rat myometrium may explain the apparent functional redundancy of the oxytocinergic system during the process of birth in animals lacking oxytocin or where the oxytocin receptor is blocked. In this context PGF(2alpha) receptor stimulation may, in the absence of oxytocin receptor stimulation, exert the contractile forces needed for proper propulsion of the fetus.

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The effects of intramyometrial injection of prostaglandin F2α on severe post-partum hemorrhage

Cited by 75 publications

References 4 publications

Calcium entry blockade as a therapeutic principle in the female urogenital tract

Calcium entry blockade as a therapeutic principle in the female urogenital tract

Inhibition of Nitric Oxide Synthesis by Systemic N<sup>G</sup>-Monomethyl-<i>L</i>-Arginine Administration in Humans: Effects on Interstitial Adenosine, Prostacyclin and Potassium Concentrations in Resting and Contracting Skeletal Muscle

Effect of Oxytocin Receptor Blockade on Rat Myometrial Responsiveness to Prostaglandin F2α1

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