In studies of human information processing, the processing stages of stimulus identification and response initiation are typically distinguished from a central processing stage that is often called response selection. Issues regarding response selection have been investigated thoroughly in two areas of research, stimulus-response compatibility(SRC) and psychologicalrefractory period (PRP) effects. Fitts and Seeger (1953) were the first to demonstrate SRC effects, showing that performance depends not only on the individual properties of the stimuli and responses but also on their relation. A large empirical base regarding SRC effects exists, along with relatively sophisticated theoretical accounts of how response selection in single-task performance is affected by compatibility relations. Telford (1931) was the first to demonstrate the PRP effect, in which, when two tasks must be performed on successive stimuli, the response to the second stimulus is delayed when the interval between stimulus onsets is short. As for SRC effects, substantial empirical and theoretical work on the PRP effect has been conducted on how response selection for one task is affected by response selection for another.Although considerable research has been conducted on the SRC and PRP effects individually, few experiments have examined the two effects jointly. A reason for the lack of studies manipulating SRC in the PRP paradigm may lie in the belief that response selection for each task occurs the same way as it does in a single-task context. However, as Duncan (1979) pointed out, "In any PRP situation, the response sets of two single tasks have been combined to give a larger total set. It is perhaps unreasonable to suppose that this leaves unaffected the complexity of response choice" (p. 225). Moreover, Hommel (1998) demonstrated that considerable interaction occurs between the two tasks. The implication is that one cannot assume that response selection for each task in dual-task contexts is performed in the same manner as when each task is performed alone. Systematic examination of SRC effects in the PRP paradigm is necessary to provide a more complete understanding of the response-selection mechanism.The purpose of the present paper, therefore, was to review SRC and PRP in the literature as they relate to issues of response selection and, most importantly, to examine in detail those studies that have looked at SRC effects in the PRP paradigm for any additional insights into the nature of response selection that they afford. We begin by reviewing SRC effects and the models developed to account for them. Such effects have been obtained for relevant and irWe thank Bernhard Hommel, Hal Pashler, and an anonymous reviewer for their helpful comments on a previous version of this manuscript. Correspondence concerning this article should be addressed to M.-C. Lien, Mail Stop 262-4, NASA Ames Research Center, Moffett Field, CA 94035 or to R. W. Proctor, Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907 (e-mail: ...