The effects of isotretinoin therapy on serum homocysteine, folate and vitamin B<sub>12</sub> levels in patients with acne: a meta‐analysis and meta‐regression

Tsai, Tsung Yu; Hsieh, Tyng Shiuan; Yang, Ting‐Hua; Wang, H.‐H.; Lin, Rongkai; Huang, Yu‐Chen

doi:10.1111/jdv.15886

Cited by 4 publications

(2 citation statements)

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“…The authors noted a higher prevalence of hyperhomocysteinemia in HS patients than healthy controls and a significant positive correlation between the plasma levels of homocysteine and disease severity (Marasca, Donnarumma, Annunziata, & Fabbrocini, ). According to Tsai et al, normal folic acid level, isotretinoin can have an inhibitory effect on homocysteine pathway (Tsai et al, ). Hence, isotretinoin has a dual effect on HS pathogenesis and associated cardiovascular comorbidities through suppression of (mTORC1) (De Vita & Melnik, ) and its effect on homocysteine, respectively.…”

Section: Indications Of Low‐dose Isotretinoin In Dermatologymentioning

confidence: 99%

“…With the low‐dose isotretinoin regimen, it is not essential to assess homocysteine and folic acid levels. However, with the higher doses or a long‐term course, the risk of increasing of the plasma homocysteine and decreasing serum folic acid level would be expected (Tsai et al, ; Van et al, ). Folate supplementation for may be suggested for patients on isotretinoin with history of depression or depressive symptoms (Abdelmaksoud et al, ).…”

Section: Safety Of Low‐dose Isotretinoinmentioning

confidence: 99%

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Low dose of isotretinoin: A comprehensive review

Abdelmaksoud

Lotti

Anadolu

et al. 2020

Dermatologic Therapy

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Isotretinoin is a first‐generation retinoid initially approved for the treatment of severe cases of acne vulgaris (nodulocystic acne). Because of its broad anti‐inflammatory and immunomodulatory properties, it has been used beyond its initial approval in a myriad of other indications. Adverse effects of isotretinoin vary from xerosis to teratogenicity. Herein, we reviewed the literature, through date‐unlimited PubMed search, from inception till December 2019, using the following search terms: “low‐dose isotretinoin” and “dermatology,” “isotretinoin and safety,” “isotretinoin, off‐label uses,” “isotretinoin and male fertility,” “isotretinoin, iPLEDGE system,” aiming to deliver a therapeutic update relevant to clinical practice. All English‐language articles were considered with no limitation based on the articles' type. Low‐dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in the field of gastroenterology. We also highlight on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotretinoin.

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Section: Indications Of Low‐dose Isotretinoin In Dermatologymentioning

confidence: 99%

Section: Safety Of Low‐dose Isotretinoinmentioning

confidence: 99%