The Effects of Jodeungsan Pharmacopuncture at GB20 on Cognitive Impairment Induced by Focal Brain Injury in Rats

Hyun, Min Kyoung; Mo, Min Ju; Hwang, Doo Ree; Yang, Tae Jun; Lee, Jung Hun; Lee, Eun Ji; Yoon, Tae Kyung; Youn, Dae Hwan

doi:10.13045/acupunct.2016054

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…The liver tissue was washed three times with PBS, cut into 50 mg samples, and lysed with 1 mL of TRIzol reagent (Thermo Fisher Scientific, Waltham, USA). Whole-cell RNA was extracted using a standard protocol [ 18 ], and the yield was measured using the nanodrop spectrophotometer (Thermo Fisher Scientific, Waltham, USA). Reverse transcription was performed using the RT 2 First Strand Kit (Qiagen, Valencia, USA), according to the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

Changes in Mitochondria-Related Gene Expression upon Acupuncture at LR3 in the D-Galactosamine-Induced Liver Damage Rat Model

Lee

Choi

Cheon

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Hepatic diseases, such as hepatonecrosis, hepatitis, and hepatocirrhosis, are associated with mitochondrial dysfunction and increased reactive oxygen species generation and inflammation, ultimately leading to liver failure. In this study, we examined if acupuncture at LR3 can affect mitochondria-related gene expression in a liver damage model of experimentally induced acute liver failure (ALF). ALF was induced by the intraperitoneal injection of D-galactosamine (D-GalN) in experimental rats, who then received either sham (ALF), manual acupuncture (MA), electroacupuncture (EA), or silymarin (PC, positive control) treatment. Liver tissues were extracted from experimental and untreated control rats for histopathological analysis and expression profiling of genes involved in mitochondrial function. Of the 168 mitochondria-related genes profiled, two genes belonging to the solute-carrier transporter family (Slc25a15 and Slc25a25) and Ndufb7 were upregulated. Gamma-glutamylcysteine synthetase was more downregulated in MA than ALF. Furthermore, MA reversed D-GalN-induced inflammatory cell infiltration, destruction of hepatic cell plates, and increase in the levels of the proinflammatory cytokine TNF-α. MA at LR3 can reduce the risk of D-GalN-induced ALF by inducing the expression of metabolic and inflammation-related genes and regulating proinflammatory factor production in hepatic mitochondria.

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Section: Methodsmentioning

confidence: 99%

Changes in Mitochondria-Related Gene Expression upon Acupuncture at LR3 in the D-Galactosamine-Induced Liver Damage Rat Model

Lee

Choi

Cheon

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Alternatively, there are studies that suggest non-drug treatment, such as cognitive training or physical exercise therapy may be helpful [7,8], but further research is needed. There is also no defined treatment for MCI in traditional oriental medicine [9,10], which have reportedly less side effects than Western drug treatment. Several randomized controlled trials (RCT) have been reported where acupuncture treatment of MCI has been evaluated including systematic review [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Acupuncture Treatment for Mild Cognitive Impairment

Yoo

Kim

et al. 2019

J Acupunct Res

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The aim of this study was to review clinical efficacy of acupuncture treatment of mild cognitive impairment. Methods: Randomized controlled trials that performed acupuncture treatment for mild cognitive impairment were retrieved from 6 online databases (PubMed, Cochrane Library, EMBASE, CNKI, NDSL, OASIS) on September 30 th , 2018. Studies were selected according to inclusion and exclusion criteria, and were reviewed by Risk of Bias assessment. Results: In total, 21 studies were included in this review. All studies were Chinese (19 studies published in Chinese and 2 in English). The sample size, 50 to 100, and the number of treatment times, 20 to 30, were the largest range in all studies. The most treatments performed was 30. The longest treatment period was 56 days, which accounted for 33% of the studies. The most frequently used evaluation index was the Mini Mental State Examination followed by the Montreal Cognitive Assessment, each used 17 times and 15 times, respectively. The most frequently used acupoints were GV20, EX-HN1, GB20, and GV24, which accounted for 47% of total number of acupoints used. In 48% of the studies, needle retention time was 30 minutes. Western medicine treatment was the most common control group. Most studies reported that the intervention group was statistically significantly different to the control group. Conclusion: These results suggest that acupuncture for mild cognitive impairment was effective. However, it is difficult to confirm this conclusion because the quality of most of these studies were of low quality.

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Korean Medical Treatment of Cognitive Impairments after Traumatic Epidural Hemorrhage: A Case Report

Song¹,

Kim²,

Kim³

et al. 2019

J Int Korean Med

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A f t e re p i d u r a l h e mo r r h a g e , s e q u e l a ema yc a u s ec o g n i t i v ei mp a i r me n t s , s u c ha sa t t e n t i o n , me mo r y , a n dp e r f o r ma n c e d i s t u r b a n c e s. Th i sc a s es t u d yr e p o r t so nt h eu s eo ft r a d i t i o n a lKo r e a nme d i c i n ei nap a t i e n twi t hc o g n i t i v ei mp a i r me n t sa f t e ra t r a u ma t i ce p i d u r a lh e mo r r h a g e. Me t h o d s : Du r i n gt h e4 6-d a yh o s p i t a l i z a t i o np e r i o d , t r a d i t i o n a l Ko r e a nme d i c i n et r e a t me n t s , i n c l u d i n gS u n k i h w a l h y u l-t a n g-g a mi b a n g , Uk g a n-s a n-g a j i n p i b a n h aGr a n u l e ,Ky u n g o h k-g o , a c u p u n c t u r e , a n dc u p p i n g , we r ea d mi n i s t e r e d. Th ed e g r e eo fc o g n i t i v ei mp a i r me n t wa sme a s u r e db a s e do nt h eMi n iMe n t a lS t a t eEx a mi n a t i o n-Ko r e a(MMS E-K) ,Mo d i f i e dB a r t h e lI n d e x(MB I) ,a n dc o r r e c t a n s we rr a t i o .

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The Effects of Jodeungsan Pharmacopuncture at GB20 on Cognitive Impairment Induced by Focal Brain Injury in Rats

Cited by 4 publications

References 27 publications

Changes in Mitochondria-Related Gene Expression upon Acupuncture at LR3 in the D-Galactosamine-Induced Liver Damage Rat Model

Changes in Mitochondria-Related Gene Expression upon Acupuncture at LR3 in the D-Galactosamine-Induced Liver Damage Rat Model

Systematic Review of Acupuncture Treatment for Mild Cognitive Impairment

Korean Medical Treatment of Cognitive Impairments after Traumatic Epidural Hemorrhage: A Case Report

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