The Effects of Kainic Acid-Induced Lesions in the Lateral Septal Area on Cell-Mediated Immune Function

Wetmore, Lisa; Green-Johnson, Julia M.; Gartner, John G.; Sanders, Virginia M.; Nance, Dwight M.

doi:10.1006/brbi.1994.1031

Cited by 10 publications

(4 citation statements)

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“…In female rats whose hippocampi were lesioned by kainate, an increase in the humoral immune response, estimated by IgG, IgA and IgM production, and a lack of changes in the cellmediated immunity, estimated by T cell proliferative activity to Con A and the NK cytotoxic activity were observed. Kainate lesions of the lateral septal area in female rats decreased the humoral immunity, increased the NK cell activity, reduced TNF-a secretion from splenic macrophages and tended to reduce the T-cell proliferative response to Con A stimulation (Nance et al, 1987;Wetmore et al, 1994). In the present study we did not observe any significant changes in the splenocyte response to Con A, this observation being in line with the above-mentioned data.…”

Section: Treatmentsupporting

confidence: 92%

Estrone, but not 17β-estradiol, attenuates kainate-induced seizures and toxicity in male mice

Budziszewska¹,

Leśkiewicz²,

Kubera³

et al. 2001

Exp Clin Endocrinol Diabetes

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Estrogens change the susceptibility to seizures in humans and experimental animals. In this study, the effect of estrone and 17 beta-estradiol on kainate-induced seizures and neurotoxicity was investigated in male mice. Pre-treatment with estrone (250-1000 micrograms/kg) at 24 and 2 hours before kainate (40 mg/kg) administration significantly decreased both the percentage of animals with clonic seizures and their mortality (the latter at a dose of 1000 micrograms/kg only). On the other hand, 17 beta-estradiol (10-500 micrograms/kg) had no effect on seizures, and its dose of 10 micrograms/kg increased mortality. When given alone at a dose of 1 mg/kg, tamoxifen, an antagonist at estrogene receptors, did not affect the kainate-induced seizures, but prevented the anticonvulsant effect of estrone. A histological analysis showed that 73% of mice injected with vehiculum and kainate incurred hippocampal damage. Estrone (2000 micrograms/kg) decreased the percentage of animals with hippocampal neuronal loss down to 43%, and that effect was not antagonized by tamoxifen. Pretreatment of mice with 17 beta-estradiol had no effect on the kainate-induced neuronal loss. Additionally, we found that kainate injected i.p. had a profound effect on the immune system of mice, as reflected by a decrease in the thymus weight and an increased metabolic activity of splenocytes. The anticonvulsive dose of estrone (1000 micrograms/kg) did not change the immunoreactivity of either control or kainate-treated mice. In conclusion, the obtained data indicate that estrone, but not 17 beta-estradiol, attenuates the kainate-induced seizures, mortality and excitotoxicity in male mice. Moreover, it is suggested that the suppressive effect of estrone on clonic seizures involves intracellular receptors, whereas its antineurotoxic activity seems to depend on a non-genomic mechanism.

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Section: Treatmentsupporting

confidence: 92%

Estrone, but not 17β-estradiol, attenuates kainate-induced seizures and toxicity in male mice

Budziszewska¹,

Leśkiewicz²,

Kubera³

et al. 2001

Exp Clin Endocrinol Diabetes

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“…After the lesion of LS with kainic acid the T cell-proliferative response to concanavalin A was reduced and NKCC was increased in rats [40] but the IgG, IgA and IgM titers were reduced [39] . The kainic acid lesion in LS also causes a decreased number of splenic plaque-forming cells and reduced TNF-␣ secretion from splenic macrophages [40] . The functional ac- Footpad swelling in MS-lesioned and sham-operated rats 2 and 3 weeks after surgery.…”

Section: Discussionmentioning

confidence: 94%

“…The results of the present study indicate a complex and differential modulatory role of MS in immunity. The LS which provides afferent fibers to the MS [31] has also been reported to be involved in differential regulation of the immune system [39,40] . After the lesion of LS with kainic acid the T cell-proliferative response to concanavalin A was reduced and NKCC was increased in rats [40] but the IgG, IgA and IgM titers were reduced [39] .…”

Section: Discussionmentioning

confidence: 99%

“…The LS which provides afferent fibers to the MS [31] has also been reported to be involved in differential regulation of the immune system [39,40] . After the lesion of LS with kainic acid the T cell-proliferative response to concanavalin A was reduced and NKCC was increased in rats [40] but the IgG, IgA and IgM titers were reduced [39] . The kainic acid lesion in LS also causes a decreased number of splenic plaque-forming cells and reduced TNF-␣ secretion from splenic macrophages [40] .…”

Section: Discussionmentioning

confidence: 99%

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Effects of Electrolytic Lesion of Medial Septum on Some Immune Responses in Rats

Dutta

Mondal

Goswami

et al. 2011

Neuroimmunomodulation

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Background/Aim: Considering the modulatory role of medial septum (MS) on behavioral and autonomic activities, and its neural connections with other brain areas having effects on the immune system, the role of MS on some immune responses has been investigated. Methods: Hyperreactivity scores, total count and differential count of WBC, phagocytic activity of blood WBC, leukocyte adhesive inhibition index (LAI), delayed type of hypersensitive (DTH) reaction and serum corticosterone (CORT) concentration were measured in MS-lesioned, sham-operated and control rats after 2 and 3 weeks of operation. The results of MS-lesioned rats were compared to those in the control and sham-operated rats. Results: The hyperreactivity score was not changed in the MS-lesioned rats. The phagocytic activity of blood WBC was increased but the DTH reaction and percentage of LAI were decreased in the MS-lesioned rats compared to the control and sham-operated rats 2 weeks after surgery. The serum CORT concentration was increased in the MS-lesioned rats compared to the control and sham-operated rats 2 weeks after surgery. After 3 weeks of MS lesion these immunological parameters and CORT concentration returned back to the normal values indicating a transient change of these parameters. Conclusion: This study concludes a complex and differential regulatory role of MS in the immune functions which are not linked with the hyperreactive behavior in rats. This immunoregulation of MS appears to be different from that of the lateral septum like their dissimilar modulatory roles in some behaviors.

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Insular Cortex Lesions Impair the Acquisition of Conditioned Immunosuppression

Ramírez‐Amaya

Alvarez-Borda

Ormsby

et al. 1996

Brain, Behavior, and Immunity

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The Effects of Kainic Acid-Induced Lesions in the Lateral Septal Area on Cell-Mediated Immune Function

Cited by 10 publications

References 0 publications

Estrone, but not 17β-estradiol, attenuates kainate-induced seizures and toxicity in male mice

Estrone, but not 17β-estradiol, attenuates kainate-induced seizures and toxicity in male mice

Effects of Electrolytic Lesion of Medial Septum on Some Immune Responses in Rats

Insular Cortex Lesions Impair the Acquisition of Conditioned Immunosuppression

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