The effects of Labisia pumila var. alata on bone markers and bone calcium in a rat model of post-menopausal osteoporosis

Shuid, Ahmad Nazrun; Ping, Leong Lee; Muhammad, Norliza; Mohamed, Norazlina; Soelaiman, Ima Nirwana

doi:10.1016/j.jep.2010.10.033

Cited by 77 publications

(69 citation statements)

References 41 publications

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“…However, postmenopausal status is associated with an increased risk of immune disorders such as rheumatoid arthritis (D'Amelio 2013) or metabolic syndromes such as obesity due to estrogen deficiency (Kaaja 2008). A systemic skeletal disease, osteoporosis, characterized by microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and low bone mass, also resulted from menopause or estrogen deficiency (Shuid et al 2011). Estrogen is a well-known regulator of bone metabolism, postmenopausal osteoporosis, and the morbidity which are major health problems in elderly women (Melton et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of porcine placenta in a menopausal ovariectomized mouse

et al. 2015

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Menopause is a significant physiological phase that occurs as women's ovaries stop producing ovum and the production of estrogen declines. Human placenta and some amino acids are known to improve menopausal symptoms. In this study, we investigated that porcine placenta extract (PPE) and arginine (Arg), a main amino acid of PPE, would have estrogenic activities in ovariectomized (OVX) mice as a menopause mouse model, human breast cancer cell line (MCF-7) cells, and human osteoblast cell line (MG-63) cells. PPE or Arg significantly inhibited the body weight and increased the vagina weight compared to the OVX mice. PPE or Arg ameliorated the vaginal atrophy in the OVX mice. The levels of 17b-estradiol and the activities of alkaline phosphatase (ALP) were significantly increased by PPE or Arg in the serum of OVX mice. Trabecular bone parameters such as bone mineral density and porosity were also improved by PPE or Arg in the OVX mice. In the MCF-7 and MG-63 cells, PPE or Arg significantly increased the cell proliferation, estrogen receptor b mRNA expression, and estrogen-response elements luciferase activity. Finally, PPE or Arg increased the activations of ALP and extracellular signalregulated kinase 1/2 in the MG-63 cells. These results indicate that PPE or Arg would have estrogenic and osteoblastic activity. Therefore, PPE or Arg may be useful as new pharmacological tools for treating menopausal symptoms including osteoporosis. Free Korean abstract: A Korean translation of this abstract is freely available at

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Section: Introductionmentioning

confidence: 99%

Protective effect of porcine placenta in a menopausal ovariectomized mouse

et al. 2015

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“…Pharmacological studies carried out on M. pumilum have reported a wide range of biologic activities in laboratory animals. These include: estrogenic (Husniza, 2002;Fazliana et al, 2009;Ayida et al, 2007), antioxidant (Norhaiza et al, 2009), antiasthmatic (Ekeuku and Okechukwu, 2012), anti-inflammatory (Choi et al, 2010, antihistaminic, antinociceptive and antiulcer Marunga, 2011, Okechukwu andEkeuku, 2012), cytotoxic (AlMekhalafi et al, 2012), antihyperlipidemic (George et al, 2014) skin protective (Chua et al, 2011), weight reduction (Pandey et al, 2104) and osteoprotective (Shuid et al, 2011) properties.…”

Section: Marantodes Pumilummentioning

confidence: 99%

“…Measuring these markers can also be used to provide useful clinical information on bone turnover rate, bone health and as a complimentary diagnostic tool to BMD (Johnell et al, 2002). In a study published in 2011 (Shuid et al, 2011), bone biomarkers and total calcium contents were investigated in eight (8) weeks M. pumilum root extract supplemented ovariectomized rats. The study revealed significantly higher levels of osteocalcin (a bone formation marker) and lower C-terminal telopeptide of type 1 collagen, CTX-1 (a bone resorption marker) in the group that received 17.5 mg/kg/day M. pumilum than in ovariectomized control group.…”

Section: Effects On Bone Turnover Markersmentioning

confidence: 99%

“…Thus, there is an increasing demand for a safer alternative to ERT for treatment and possible prevention of osteoporosis in postmenopausal women (Rees, 2011). In this light, investigations have been carried out on a number of natural agents such as soy and blueberry (Devareddy et al, 2006;Devareddy et al, 2008), Achyranthes bidentata (He et al, 2010), M. pumilum (Shuid et al, 2011) and virgin coconut oil (Soelaiman et al, 2013). This article is aimed at reviewing relevant research data on the osteoprotective and related pharmacological attributes of M. pumilum (MPva).…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic potentials of Marantodespumilum (Blume) Kuntze var. alataas antiresorptive agent in management of postmenopausal osteoporosis

Giaze¹,

Shuid²,

Mohamed³

2017

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Due to increasing population of the elderly owing to higher life expectancy, osteoporosis in postmenopausal women has become a primary public health problem, posing huge economic and social burden today. Globally, approximately 200 million women are affected by this condition worldwide. One of every 3 women above 50 years was reported to experience fractures secondary to osteoporosis. Out of 8.9 million fractures (hip: 1.6 million, forearm: 1.7 million, clinical vertebral: 1.4 million) recorded annually, 61% occurred in women. Hormone replacement therapy (HRT) using estrogen has been a valuable treatment option in the management of postmenopausal osteoporosis. Due to adverse side effects such as breast, colorectal and endometrial cancer, pulmonary embolism and stroke associated with long term use of estrogen, HRT is now reserved for treatment of pressing postmenopausal symptoms such as hot flashes and vaginal dryness. Currently, a wide range of other agents such alendronate, raloxifene, calcitonin, vitamin D and calcium are recommended and used as alternatives. But, like HRT, these agents are also known to be associated with debilitating side effects that often hamper compliance to drug regimen. Thus, alternative and complimentary therapies for treating postmenopausal osteoporosis are being sorted for. Marantodes pumilum (Blume) Kuntze var alata, a phytoestrogen-rich herb, is one of the numerous natural agents that have been reported to be useful in protecting the bone against osteoporosis and is currently recommended for ma nagement of postmenopausa l symptoms. Researchers have reported protection of estrogen deficient animals against osteoporosis. In this article, the potentials of M. pumilum to be used as a safe alternative to estrogen in managing postmenopau sal osteoporosis wa s explored by reviewing releva nt published data on its osteoprotective and related pharmacological activities from reputable and reliable databases.

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“…Berdasarkan penelitian Shuid et al (2011), bahwa hasil marker biokimia tulang menunjukkan perubahan karakteristik osteoporosis pada tikus ovariektomi. Osteokalsin merupakan protein non kolagen yang disintesis oleh osteoblas dan pada umumnya dianggap sebagai marker spesifik untuk aktivitas osteoblastik dan untuk pembentukan tulang.…”

Section: Metodeunclassified

Efek Pemberian Ekstrak Rumput Fatimah (Labisia Pumila) Terhadap Osteokalsin Serum Dan Deoxypiridinolin Urin Pada Tikus Post Ovariektomi

Mariati¹

2017

Jurnal Ilmu Keperawatan dan Kebidanan

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AbstrakTujuan : Penelitian ini bertujuan untuk mengetahui efek pemberian ekstrak rumput fatimah (Labisia pumila) terhadap osteokalsin serum dan deoxypiridinolin urin pada tikus post ovariektomi. Metode : Penelitian ini merupakan penelitian eksperimental, dilakukan di laboratorium Farmakologi dan Fisiologi Fakultas Kedokteran Universitas Brawijaya malang. Menggunakan tikus ovariektomi. Penelitian ini dibagi menjadi 5 kelompok, yaitu 1 kelompok kontrol negatif, 1 kelompok kontrol positif dan 3 kelompok perlakuan pemberian ekstrak rumput fatimah. Pengukuran osteokalsin dan deoxypiridinolin menggunakan elisa kit. Data hasil penelitian dianalisis dengan teknik analisis data.Hasil : Terdapat pengaruh pemberian ekstrak rumput fatimah terhadap penurunan osteokalsin serum dan peningkatan deoxypiridinolin urin pada tikus post ovariektomi. Tidak terdapat hubungan yang signifikan antara ekspresi deoxypiridinolin dengan ekspresi osteokalsin, hal ini menunjukkan bahwa perubahan ekspresi deoxypiridinolin tidak diikuti perubahan pada ekspresi osteokalsin. Pemberian rumput fatimah mampu mempengaruhi perubahan ekspresi deoxypiridinolin sebesar 53,46% dan perubahan ekspresi osteokalsin sebesar 66,97%. Sisanya dijelaskan oleh faktor lain yang tidak terlibat dalam penelitian. Kesimpulan : Pemberian ekstrak rumput fatimah dapat menurunkan osteokalsin serum dan meningkatkan deoxypiridinolin urin pada tikus post ovariektomi.Kata Kunci : Rumput Fatimah, Osteokalsin, Deoxypiridinolin Abstract Objective: This study was intended to investigate the extracurricular effects of serum osteocalcin and urinary deoxypiridinoline in post ovariectomy. Method: This research is an experimental research, conducted in Pharmacology and Physiology laboratory of Faculty of Medicine Universitas Brawijaya malang. Using ovariectomy rats. The study was divided into 5 groups, ie 1 group of negative control, 1 group of positive control and 3 treatment groups from grass fatimah extract. Measurement of osteocalcin and deoxypiridinoline using elisa kit. The result data were analyzed by data analysis technique. Result: There was an effect of giving fatimah grass extract to decrease of serum osteocalcin and increasing urine deoxypiridinolin in post ovariectomy rats. There was no significant association between deoxypiridinolin expression with osteocalcin expression, it showed that deoxypiridinolin expression changes did not follow changes in osteocalcin expression. Grass giving fatimah can change. The rest is explained by other factors not involved in the research. Conclusions: Provision of grass fatimah extract may decrease serum osteocalcin and increase urine deoxypiridinoline in mice after ovariectomy.

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The effects of Labisia pumila var. alata on bone markers and bone calcium in a rat model of post-menopausal osteoporosis

Cited by 77 publications

References 41 publications

Protective effect of porcine placenta in a menopausal ovariectomized mouse

Protective effect of porcine placenta in a menopausal ovariectomized mouse

Therapeutic potentials of Marantodespumilum (Blume) Kuntze var. alataas antiresorptive agent in management of postmenopausal osteoporosis

Efek Pemberian Ekstrak Rumput Fatimah (Labisia Pumila) Terhadap Osteokalsin Serum Dan Deoxypiridinolin Urin Pada Tikus Post Ovariektomi

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