The Effects of Lead Exposure on Serum Uric Acid and Hyperuricemia in Young Adult Workers: A Cross-sectional Controlled Study

Baki, Ali Erdem; Ekiz, Timur; Öztürk, Gökhan Tuna; Tutkun, Engın; Yilmaz, Hınç; Yıldızgören, Mustafa Turgut

doi:10.5606/archrheumatol.2016.5955

Cited by 11 publications

(5 citation statements)

References 20 publications

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“…The prevalence of hyperuricemia was significantly higher in the automobile mechanics compared to the control. This finding is keeping with report of previous studies conducted within and outside Nigeria [ 9 , 32 , 47 , 48 ]. Hyperuricemia is a non-traditional cardiovascular risk factor that is associated with target organ damage, cardiovascular morbidity and mortality [ 49 ].…”

Section: Discussionsupporting

confidence: 93%

Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study

Adejumo,

Enikuomehin,

Ogunleye

et al. 2023

PLoS ONE

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Introduction The burden of cardiovascular disease (CVD) is huge due to its associated morbidity, mortality and adverse socio-economic impact. Environmental pollution as a risk factor contributes significantly to the burden of CVD, especially in the low and middle income countries. One of the effective strategies to reduce CVD burden is to prevent or detect cardiovascular risk factors early in at-risk population. This study determined some cardiovascular risk factors, kidney function, and their association with heavy metals among automobile mechanics. Method This was a cross-sectional study involving 162 automobile mechanics and 81 age and sex matched controls. Serum levels of lead, cadmium and some cardiovascular risks were assessed and compared in the two groups. Associations between serum lead, cadmium and some cardiovascular risks were determined using correlation analysis. P value of <0.05 was taken as significant. Results The mean ages of the automobile mechanics and controls were 47.27±9.99 years and 48.94±10.34 years, respectively. The prevalence of elevated serum cadmium was significantly higher in the automobile mechanics (25.9% vs 7.9%; p = <0.001). The significant cardiovascular risk factors in the automobile mechanics vs controls were elevated total cholesterol (32.1% vs 18.5%; p = 0.017), hyperuricemia (20.4% vs 1.2%; p = <0.001), elevated blood glucose (16.0% vs 4.9% p = 0.013); and alcohol use (55.1% vs 30.0%; p = 0.001). Among the automobile mechanics, there were significant positive correlations between serum cadmium, atherogenic index of plasma (AIP) (p = 0.024; r = 0.382) and triglyceride (p = 0.020; r = 0.391). Significant positive correlation was found between serum lead and neutrophil gelatinase associated lipocalin (NGAL) (p = <0.001; r = 0.329). There were significant positive correlation between serum cadmium level, AIP (p = 0.016; r = 0.373) and TG (p = 0.004; r = 0.439); between serum lead and NGAL in all the study participants (p = 0.005; r = 0.206). Conclusion Automobile mechanics have notable exposure to heavy metals and a higher prevalence of some cardiovascular risk factors. Health education and sensitisation as well as policies that would regulate exposure of persons to heavy metals should be implemented in Nigeria.

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Section: Discussionsupporting

confidence: 93%

Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study

Adejumo,

Enikuomehin,

Ogunleye

et al. 2023

PLoS ONE

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“…Similar effects were also noticed in the group 5-10 years and in less than five years of exposure, showing a gradual increase in the levels of uric acid (6.64, 4.64 ± 3.76), respectively, compared with that of control groups **p<0.01. Similar effects were reported in workers with lead exposure have a higher frequency of hyperuricemia and higher serum uric acid levels than those of the control group the higher serum uric acid levels may be associated with renal impairment [22].…”

Section: Discussionsupporting

confidence: 77%

Renal Impairments in Stone Quarry Workers

Bama,

Sundaramahalingam,

Anand

2023

Cureus

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Introduction Exposure to dust due to stone quarrying can cause severe respiratory ailments. Besides lung problems, research shows that exposure to quarry dust may also increase the risk of health problems affecting the heart, liver, kidney, central nervous system, and other organs. Despite the fact that a lot of studies have been reported on the respiratory system, our aim was to explore the evidence on the association between occupational exposure to quarry dust and its effect on renal health. Methodology This study was conducted on 75 quarry workers and 45 healthy matched controls were recruited from Allukuzhi village. Blood samples were collected and their kidney parameters were assessed in Hitech Diagnostics, Kanchipuram. Data were analyzed using ANOVA and strength of association was determined by Pearson correlation at significance p=0.05*. Results The obtained results showed a significant increase in the level of creatinine (1.02±0.31), urea (24.62±8.52), and uric acid (5.13±1.31) in quarry workers upon the duration of exposure to quarry dust compared with control subjects (p < 0.05*). Conclusion The results of this study suggest a significant correlation between exposure to quarry dust and its reduced renal function. This could suggest that the quarry work site should have proper hazard control measures and safety precautionary equipment for the workers. Also, to be educated about the importance of the safety measures which have to be practiced in order to protect them from occupational hazards.

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“…Moreover, the significantly increased serum and urine uric acid levels with painting exposure in both car and furniture painters is an indication of hyperuricemia. Baki et al(2016) observed the same results with adult males aged (20-50) years who occupationally exposed to Pb for at least one year through employment in the following jobs; petrol attendants and refinery, battery factory, car radiatair repair, as well as paint pigments and corrosion pipe filters. Mohamed et al, (2003) explained this elevation may result from increased catabolism of tissue proteins, that could be considered as good indication of damaged kidney due to larger perfusion and increased concentrations of excreted compounds occurred in renal tubular cells.…”

Section: Resultssupporting

confidence: 66%

Related health hazards with occupational exposure to cadmium and lead during spray painting in car and furniture workshops

Abdraboh

2023

Journal of Environmental Sciences. Mansoura University

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Spray painting workers in car and furniture workshops are occupationally exposed to intense painting vapors. The main objective of this study is to evaluate health risk resulting from exposure to paintings spray, especially related to the included cadmium (Cd) and lead (Pb) metals. The studied groups (15-60) years old, were all non-smoker males; 20 workers selected from 6 car painting workshops, 30 from 6 furniture painting workshops and 20 healthy subjects away from exposure to paintings or other chemicals represented control group. Results showed significantly increased levels of Cd and Pb in serum and urine of car and furniture painters compared to control subjects, where metals concentration in car workers were more than in furniture ones. Results showed significant decrease in hemoglobin content, red blood cells and platelets count, along with significant increase in total leucocytes count in car and furniture painters compared to unexposed subjects. In parallel, disturbed liver and kidney functions represented by significant reduction in serum total protein and albumin contents were observed, along with remarkable elevation in aspartate aminotransferase, alanine aminotransferase, creatinine and uric acid. These results were accompanied by significant increase in urine total protein and albumin contents, as well as creatinine in exposed groups compared to control subjects. However, serum acetylcholinesterase levels decreased significantly in both car and furniture painters compared to control subjects. So, car and furniture painters are in potential risk lying through working environment, which requires attention, mitigations, and management to protect their health.

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The Effects of Lead Exposure on Serum Uric Acid and Hyperuricemia in Young Adult Workers: A Cross-sectional Controlled Study

Cited by 11 publications

References 20 publications

Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study

Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study

Renal Impairments in Stone Quarry Workers

Related health hazards with occupational exposure to cadmium and lead during spray painting in car and furniture workshops

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