The Effects of Lemon balm (Melissa officinalis L.) Alone and in Combination With Nepeta menthoides on the Menstrual Bleeding in Students With Premenstrual Syndrome: A Randomized Controlled Trial

Mirghafourvand, Mojgan; Malakouti, Jamileh; Mohammad‐Alizadeh‐Charandabi, Sakineh; Farshbaf‐Khalili, Azizeh; Ghanbari‐Homayi, Solmaz

doi:10.5812/ircmj.28941

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…On the other hand, the biochemical analysis showed that the combination of ineffective doses significantly increased CAT activity in the brain. However, Mirghafourvand, Malakouti, Mohammad, Farshbaf, and Ghanbari (2016) reported that there was no statistically significant difference between extracts alone and their combinations in their clinical trial. It seems that further animal and clinical studies are needed to demonstrate that the combination of two plants has no difference with their single‐use.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effects of Nepeta menthoides and Melissa officinalis aqueous extracts on reserpine‐induced depressive‐like behaviors in mice

Talebi

Rahmati

Jorjani

et al. 2022

Phytotherapy Research

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Nepeta menthoides Boiss. & Buhse and Melissa officinalis are extensively used in Persian medicine for the treatment of depression. Considering the active ingredients and main phenolic compounds of these plants and possible synergistic effects, this study examined the antidepressant and antioxidant activities of aqueous extract of N. menthoides (NM) and M. officinalis (MO) in reserpinized mice alone and combination. Mice were pretreated orally for 1‐week with normal saline (10 ml/kg), fluoxetine (20 mg/kg), imipramine (10 mg/kg), NM (50–100–200–400 mg/kg), MO (150–350–550–750 mg/kg), and combination (NM 50 with MO 150 mg/kg). The behavioral changes were evaluated using forced swim, tail suspension, and open field tests, 24 hr after reserpine injection (4 mg/kg) on eighth day. The amounts of active components in the extracts and catalase (CAT) as a brain oxidative stress were measured with enzyme‐linked immunosorbent assay. Data showed that this combination produced a synergistic action on behaviors and a significant increase in CAT activity. High‐performance liquid chromatography results showed that rosmarinic acid contents in MO and NM were 6.42 ± 1.1 and 11.03 ± 2.16 mg/g of dried extract, respectively. Total flavonoid and phenolic contents of MO were higher than NM. The findings suggest that the present combination produces an antidepressant‐like effect, which is possibly triggered by its antioxidant properties.

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Section: Discussionmentioning

confidence: 99%

Synergistic effects of Nepeta menthoides and Melissa officinalis aqueous extracts on reserpine‐induced depressive‐like behaviors in mice

Talebi

Rahmati

Jorjani

et al. 2022

Phytotherapy Research

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“…Some studies have assessed the effects of some herbal drugs on menstrual bleeding (20,21). However, according to a systematic review, further well-designed trials are recommended to investigate the safety and efficacy of herbs in the treatment of women with menorrhagia (22).…”

Section: Introductionmentioning

confidence: 99%

Effects of Mefenamic Acid Versus Quince on Menorrhagia and Quality of Life: A Randomized Controlled Trial

Rahi

Mirghafourvand

Mohammad‐Alizadeh‐Charandabi

et al. 2017

Iran Red Crescent Med J

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Objectives: To compare the effects of mefenamic acid versus quince on menorrhagia and quality of life. Methods: This randomized controlled trial was conducted on women with menorrhagia. The participants were allocated into 2 groups through block randomization. The first group (n, 72) received quince pills, while the second group (n, 74) used mefenamic acid pills for 3 consecutive cycles. The participants completed the pictorial blood loss assessment chart (PBAC) before and during the intervention. Moreover, the short-form health survey (SF-36) was completed before and 3 months after the intervention. Results: The mean PBAC scores decreased significantly in both groups. The mean PBAC score in the quince group decreased from 173.6 (SD, 53.8) before the intervention to 116.7 (51.7), 86.4 (43.1), and 68.9 (36.4), respectively in the first, second, and third months after the intervention. The mean PBAC scores in the mefenamic acid group was 176.8 (54.3) at baseline and 106.6 (50.40), 81.6 (38.7), and 63.8 (33.8), respectively in the first, second, and third months after the intervention. There was no significant difference between the groups in terms of the mean PBAC score (P = 0.183). Similarly, after the intervention, there was no significant difference between the groups in terms of physical health (P = 0.476) and mental health (P = 0.572) components of quality of life. Conclusions: Quince pills were as effective as mefenamic acid pills in reducing the intensity of menstrual bleeding. Therefore, they seem to be a proper alternative for mefenamic acid.

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Therapeutic applications of lemon balm (Melissa officinalis) for obstetrics and gynecological health issues: A systematic review

Alimoradi,

Jafari,

Abdi

et al. 2023

Journal of Herbal Medicine

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The Effects of Lemon balm (Melissa officinalis L.) Alone and in Combination With Nepeta menthoides on the Menstrual Bleeding in Students With Premenstrual Syndrome: A Randomized Controlled Trial

Cited by 4 publications

References 15 publications

Synergistic effects of Nepeta menthoides and Melissa officinalis aqueous extracts on reserpine‐induced depressive‐like behaviors in mice

Synergistic effects of Nepeta menthoides and Melissa officinalis aqueous extracts on reserpine‐induced depressive‐like behaviors in mice

Effects of Mefenamic Acid Versus Quince on Menorrhagia and Quality of Life: A Randomized Controlled Trial

Therapeutic applications of lemon balm (Melissa officinalis) for obstetrics and gynecological health issues: A systematic review

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