The effects of leptin hormone on locomotor activity in Syrian hamsters (Mesocricetus auratus)

Gündüz, Bülent; Karakaş, Alper

doi:10.3906/biy-1008-63

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Both photic and non-photic cues play a role in mediating SCN. Leptin, for instance, may alter SCN's rhythm and lead to a phase shift in the circadian clock (Gündüz and Karakaş, 2011;Mendoza et al, 2011). In addition, neuronal networks between the arcuate nucleus and SCN can regulate food intake (Querioz et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Circadian Rhythm and Leptin Hormone Responses to Nutritional Restriction in Gerbils (Meriones unguiculatus) with Suprachiasmatic Nucleus Lesions

GÜNDÜZ,

ÖNDER,

EKİN

et al. 2023

Comm. J. Biol.

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Rhythmically-regulated feeding behavior is in harmony with physiologic and metabolic activities in mammals. This rhythmic regulation is orchestrated by Suprachiasmatic Nucleus (SCN). However, it is not entirely clear how the SCN, which generates endogenous (internal) rhythms, influences body weight and serum leptin profile with activity rhythms in relation to feeding timing. In this study, animals in long photoperiod (14L:10D) were divided into two groups as control (sham-SCNx) and SCN lesions (SCNx). Then, these groups were split into four separate subgroups: a) ad libitum feeding; b) feeding only during the dark phase; c) feeding only during the light phase; and d) feeding during a specific period of the day (11:00-14:00 h). Locomotor activity and leptin hormone changes were observed in animals fed in cages attached to activity wheels for one month. Under the conditions of food restriction, the locomotor activities of the groups with SCNx and sham-SCNx demonstrated a phase shift toward the time of feeding. Serum leptin level did not change with feeding conditions but decreased in lesioned groups (SCNx). In conclusion, nutritional restriction caused phase shifts in activity rhythms and it was found that the SCN in gerbils was in charge of these rhythmic changes in the presence and absence of nutrients.

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Section: Introductionmentioning

confidence: 99%