The effects of lesions in the dorsolateral pons on the coordination of swallowing and breathing in awake goats

Bonis, Joshua M.; Neumueller, Suzanne; Marshall, B. D.; Krause, Katie; Qian, Baogang; Pan, Lawrence; Hodges, Matthew R.; Forster, H. V.

doi:10.1016/j.resp.2010.12.002

Cited by 37 publications

(44 citation statements)

References 22 publications

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“…A total of 20 studies were identified that reported a relationship between KF and cranial nerve function, and these involved the trigeminal (6 studies) [14][15][16][17][18][19], vagus (9) [4,[20][21][22][23][24][25][26][27] and hypoglossal (5) [28][29][30][31][32] nerves. The experimental techniques used in obtaining these findings are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…There were 9 studies that reported on vagus nerve function related to the KF [4,[20][21][22][23][24][25][26][27]. Six papers discussed the role of KF in laryngeal adductor control [4,21,[24][25][26][27].…”

Section: Resultsmentioning

confidence: 99%

“…The KF was observed to participate in swallowing function in 4 studies [20][21][22][23]. The KF inhibited non-nutritive swallowing [20,21] and was also found to play a role in coordinating respiratory rhythm during swallowing [22,23].…”

Section: Resultsmentioning

confidence: 99%

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The Kölliker-Fuse nucleus: a review of animal studies and the implications for cranial nerve function in humans

Browaldh

Bautista

Dutschmann

et al. 2015

Eur Arch Otorhinolaryngol

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To review the scientific literature on the relationship between Kölliker-Fuse nucleus (KF) and cranial nerve function in animal models, with view to evaluating the potential role of KF maturation in explaining age-related normal physiologic parameters and developmental and acquired impairment of cranial nerve function in humans. Medical databases (Medline and PubMed). Studies investigating evidence of KF activity responsible for a specific cranial nerve function that were based on manipulation of KF activity or the use of neural markers were included. Twenty studies were identified that involved the trigeminal (6 studies), vagus (9), and hypoglossal nerves (5). These pertained specifically to a role of the KF in mediating the dive reflex, laryngeal adductor control, swallowing function and upper airway tone. The KF acts as a mediator of a number of important functions that relate primarily to laryngeal closure, upper airway tone and swallowing. These areas are characterized by a variety of disorders that may present to the otolaryngologist, and hence the importance of understanding the role played by the KF in maintaining normal function.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Kölliker-Fuse nucleus: a review of animal studies and the implications for cranial nerve function in humans

Browaldh

Bautista

Dutschmann

et al. 2015

Eur Arch Otorhinolaryngol

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“…EMG signals from both the MyHy and diaphragm were used to determine which respiratory phase predominates after injury (Bonis et al, 2011;Doty & Bosma, 1956;German et al, 2009;Thexton et al, 2007). Bursts in the MyHy EMG signal denoted the beginning of the pharyngeal swallowing phase (Doty & Bosma, 1956;Thexton et al, 2007), which can be compared to phasic diaphragmatic activity, revealing information on the expiration (minimal to zero diaphragmatic signal) or inspiration (diaphragmatic signal spike) pattern during swallowing (Bonis et al, 2011).…”

Section: Thoracic Diaphragmmentioning

confidence: 99%

“…Bursts in the MyHy EMG signal denoted the beginning of the pharyngeal swallowing phase (Doty & Bosma, 1956;Thexton et al, 2007), which can be compared to phasic diaphragmatic activity, revealing information on the expiration (minimal to zero diaphragmatic signal) or inspiration (diaphragmatic signal spike) pattern during swallowing (Bonis et al, 2011).…”

Section: Thoracic Diaphragmmentioning

confidence: 99%

Swallow and breathing coordination following suprahyoid muscle injury.

Kimbel¹

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DEDICATIONTo my wife, Kate, for all her support and patience. iv ACKNOWLEDGMENTS First, I would like to thank my thesis advisor at the University of Louisville. She provided invaluable input into the thesis process. Her knowledge base related to the scope of this paper was instrumental in its publication. Further, she was patient and forthright in her feedback. Under her tutelage, I fostered a newly found passion for research. Swallowing motility disorders (dysphagia) are a major complication following radiation treatment for head and neck cancer, affecting ~50% of those treated. One reason for this is that radiation causes muscle damage, provoking sensorimotor pathologies.Previous work has suggested that injury may cause discoordination between breathing and swallowing behaviors. We sought to determine if muscle injury provokes changes in this behavior. We hypothesized that acute suprahyoid muscle damage would alter crossbehavior excitability, causing destabilization of the respiratory-swallow pattern.Swallowing was evoked in anesthetized spontaneously breathing cats via injection of a 3cc bolus of water into the oropharyngeal cavity. A suprahyoid injury was induced unilaterally by applying a ~2mm cryoprobe to the belly of the mylohyoid muscle.Electromyography (EMG) activity (duration, amplitude) was measured concurrently in thyrohyoid, mylohyoid, thyropharyngeal, and diaphragm muscles. Swallow-breathing coordination (SBC) was measured by determining inspiration/expiration phase during the onset and offset of a swallowing event, based off the mylohyoid initiation and thyropharyngeal termination bursts, respectively. Results showed an injury-related effect in the mylohyoid muscle, as indicated by a significant decrease in the mean amplitude vi post-injury compared to pre-injury. During swallowing, the expiratory phase was found to predominate the respiratory cycle in both pre-and post-injury. No significant changes to the swallow-breathing coordination were found following injury. Results demonstrate that mylohyoid muscle injury does not appear to interfere with short-term changes in the respiratory-swallow pattern. Although deficits in muscle function were found immediately following injury, an extended time or more severe injury may be needed to adversely inhibit these behaviors. Thus, disrupting the stable coupling between respirations and swallowing, which has been found clinically, may not be apparent immediately after injury and require long-term changes in function.

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Pontine Mechanisms of Respiratory Control

Dutschmann

Dick

2012

Comprehensive Physiology

227

201

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Pontine respiratory nuclei provide synaptic input to medullary rhythmogenic circuits to shape and adapt the breathing pattern. An understanding of this statement depends on appreciating breathing as a behavior, rather than a stereotypic rhythm. In this review, we focus on the pontine-mediated inspiratory off-switch (IOS) associated with postinspiratory glottal constriction. Further, IOS is examined in the context of pontine regulation of glottal resistance in response to multimodal sensory inputs and higher commands, which in turn rules timing, duration, and patterning of respiratory airflow. In addition, network plasticity in respiratory control emerges during the development of the pons. Synaptic plasticity is required for dynamic and efficient modulation of the expiratory breathing pattern to cope with rapid changes from eupneic to adaptive breathing linked to exploratory (foraging and sniffing) and expulsive (vocalizing, coughing, sneezing, and retching) behaviors, as well as conveyance of basic emotions. The speed and complexity of changes in the breathing pattern of behaving animals implies that “learning to breathe” is necessary to adjust to changing internal and external states to maintain homeostasis and survival.

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The effects of lesions in the dorsolateral pons on the coordination of swallowing and breathing in awake goats

Cited by 37 publications

References 22 publications

The Kölliker-Fuse nucleus: a review of animal studies and the implications for cranial nerve function in humans

The Kölliker-Fuse nucleus: a review of animal studies and the implications for cranial nerve function in humans

Swallow and breathing coordination following suprahyoid muscle injury.

Pontine Mechanisms of Respiratory Control

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