The effects of lesions of the thalamic intergeniculate leaflet on the pineal metabolism

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

“…In addition, the activity of these three structures is directly (IGL, raphe) or indirectly (PVN) modulated by light. Since short light exposure at night induces a very rapid diminution of MEL synthesis and release Illnerova et al, 1979;Drijfhout et al, 1996c), it is possible that the central pathway involved in this rapid light inhibition (Dafny, 1980) that the central IGL-pineal pathway could be involved in the rapid inhibitory effect of a light flash on the metabolic activity of the pineal gland (Cipolla-Neto et al, 1995;Bartol et al, 1997).…”

The Role of the Retrochiasmatic Area in the Control of Pineal Metabolism

“…NAS was assayed by HPLC with electrochemical detection, as described before [2]. In summary, each gland was sonicated and centrifuged and the clear supernatant was injected (20 µl loop) into the chromatographic system (Waters, Milford, Mass., USA) using 10% methanol as the mobile phase.…”

“…In previous studies [1, 2, 3]we demonstrated that the thalamic intergeniculate leaflet (IGL) is involved in the regulation of the amplitude of the diurnal curve of N-acetylserotonin (NAS) production and in the rapid photoinhibition process of its synthesis in the pineal gland. Moreover, we showed that part of these effects was mediated by the geniculohypothalamic tract, probably by its projection to an anatomical structure situated downstream from the SCN.…”

Ações da metilecgonidina sobre a síntese de melatonina na glândula pineal de ratos.

“…Acredita-se que esse efeito inibitório imediato deve-se à inervação proveniente do IGL que contém principalmente o neurotransmissor GABA (CIPOLLA-NETO et al, 1995). As fibras peptidérgicas são abundantes e juntamente com outros neurotransmissores permitem que os pinealócitos entrem em contato com uma grande variedade de substâncias como, ocitocina, substância P, dopamina, serotonina (5-HT), peptideo intestinal vasoativo (VIP), vasopressina (VP), acetilcolina, ácido gamaaminobutírico (GABA).…”