The Effects of Lincomycin-Spectinomycin and Sulfamethoxazole-Trimethoprim on Hyaluronidase Activities and Sperm Characteristics of Rams

Tanyıldızı, Sadettin; Bozkurt, Tanzer

doi:10.1292/jvms.65.775

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…The study claims that, use of ivermectin may not be suitable during ramming season due to the possible deleterious effects on fertility. A combination of antibiotics such as lincomycin-spectinomycin is used in the treatment of virulent footrot of sheep, ovine dermatophilosis, respiratory infections and infectious arthritis in animals [166]. Additionally, this antibiotic combination has been used in the treatment of breeding rams with semen contaminated with ureaplasmas.…”

Section: Antibiotics/anti-nematodesmentioning

confidence: 99%

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Hyaluronidase Inhibitors: A Biological and Therapeutic Perspective

Girish¹,

Kemparaju²,

Nagaraju

et al. 2009

CMC

139

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The hyaluronidases (HAases) are a group of less extensively studied glycosidases distributed throughout the animal kingdom and are popularly known as 'spreading factors'. In recent years, HAases received much attention due to their ability to abruptly alter the hyaluronic acid (HA) homeostasis. HAases preferentially degrade HA, which is a megadalton acidic structural polysaccharide found exclusively in the extracellular matrix (ECM) of animals. The HA-HAase system has been suggested to participate in many pathophysiological conditions. The HA degradation in ECM, crack down the structural integrity with an eventual increased tissue permeability that is attributed for the spreading property. The spreading property has been widely accepted in functions including envenomation, acrosomal reaction/ovum fertilization, cancer progression, microbial pathogenesis such as wound infections, pneumonia, and other sepses like, bacteremia and meningitis. HA fragmentation has dual effects; generation of a wide molecular range bioactive oligosaccharides of angiogenic, pro-inflammatory, and immunostimulatory properties; and impairment in the reservoir capacity of ECM that holds metal ions, growth factors, cytokines and various enzymes for signal transduction. Hence, inhibition of HA degradation appears critical and imperative in HAase mediated pathological conditions. HAase inhibitors are thus potent regulators that maintain HA homeostasis and they might serve as anti-inflammatory, anti-aging, anti-microbial, anticancer and anti-venom/toxin and contraceptive agents. In addition, HAase inhibitors may serve as tools to understand several unexplained and complex functions of HAases in HA metabolism. Therefore, this review is expected to provide an integrated update as of 2008 on the HAase inhibitors and their possible role as therapeutics in the management of a wide range of pathological conditions.

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Section: Antibiotics/anti-nematodesmentioning

confidence: 99%

“…In summary, both the combination of antibiotics did not alter the HAase activity and sperm motility. However, use of both the combinations in breeding rams during ramming season is not advisable due to decreased sperm count [166].…”

Section: Antibiotics/anti-nematodesmentioning

confidence: 99%

Hyaluronidase Inhibitors: A Biological and Therapeutic Perspective

Girish¹,

Kemparaju²,

Nagaraju

et al. 2009

CMC

139

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“…Although there are some studies on the effects of hyaluronidases obtained from the seeds on mobility and bacteriological attacks (Tanyildizi and Bozkurt, 2003), still there is lack of information in the literature about the effects of some antibiotics on the BTH enzyme, which increases the originality of this study.…”

Section: Resultsmentioning

confidence: 99%

In vitro effects of 2, 4-Dichlorophenoxy acetic acid dimethylamine salt and enrofloxacin on BTH

Kaya

2017

IJAR

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In this study, the in vitro effects of enrofloxacin, a broad spectrum antibiotic, and 2, 4-Dichlorophenoxy acetic acid dimethylamine salt that, a herbicide, on the bovine testicular hyaluronidase (BTH) were analyzed. BTH was purified using the method of ammonium sulfate precipitation and using affinity gel (Sepharose-4B-L-tyrosine-m-anisidine). Then the inhibiting effects of enrofloxacin and 2, 4-Dichlorophenoxy acetic acid dimethylamine salt on the purified BTH enzyme were identified. IC 50 values of these chemical substances were found to be 0.3101 and 0.4276 mM, respectively.

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Section: Impact Of Cecs On Male Fertilitymentioning

confidence: 99%

“…Table 1 [54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] includes a summary of the effects of several CECs grouped as pesticides and pharmaceuticals on male fertility (e.g., hormone levels, testis size and structure, and sperm characteristics) in different species. Example of CECs listed in Table 1 [54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] included both in vivo and in vitro treatments and illustrates the broad negative reproductive effects that CECs have. Overall, collective findings indicate defects in reproductive function across a wide range of marine and terrestrial animals including fish [70], birds [71], alligators, turtles, salamanders [72], mice [73], and panthers [74], when exposed to CECs.…”

Section: Impact Of Cecs On Male Fertilitymentioning

confidence: 99%

Contaminants of Emerging Concern (CECs) and Male Reproductive Health: Challenging the Future with a Double-Edged Sword

Marcu

Keyser

Petrik

et al. 2023

Toxics

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Approximately 9% of couples are infertile, with half of these cases relating to male factors. While many cases of male infertility are associated with genetic and lifestyle factors, approximately 30% of cases are still idiopathic. Contaminants of emerging concern (CECs) denote substances identified in the environment for the first time or detected at low concentrations during water quality analysis. Since CEC production and use have increased in recent decades, CECs are now ubiquitous in surface and groundwater. CECs are increasingly observed in human tissues, and parallel reports indicate that semen quality is continuously declining, supporting the notion that CECs may play a role in infertility. This narrative review focuses on several CECs (including pesticides and pharmaceuticals) detected in the nearshore marine environment of False Bay, Cape Town, South Africa, and deliberates their potential effects on male fertility and the offspring of exposed parents, as well as the use of spermatozoa in toxicological studies. Collective findings report that chronic in vivo exposure to pesticides, including atrazine, simazine, and chlorpyrifos, is likely to be detrimental to the reproduction of many organisms, as well as to sperm performance in vitro. Similarly, exposure to pharmaceuticals such as diclofenac and naproxen impairs sperm motility both in vivo and in vitro. These contaminants are also likely to play a key role in health and disease in offspring sired by parents exposed to CECs. On the other side of the double-edged sword, we propose that due to its sensitivity to environmental conditions, spermatozoa could be used as a bioindicator in eco- and repro-toxicology studies.

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The Effects of Lincomycin-Spectinomycin and Sulfamethoxazole-Trimethoprim on Hyaluronidase Activities and Sperm Characteristics of Rams

Cited by 7 publications

References 25 publications

Hyaluronidase Inhibitors: A Biological and Therapeutic Perspective

Hyaluronidase Inhibitors: A Biological and Therapeutic Perspective

In vitro effects of 2, 4-Dichlorophenoxy acetic acid dimethylamine salt and enrofloxacin on BTH

Contaminants of Emerging Concern (CECs) and Male Reproductive Health: Challenging the Future with a Double-Edged Sword

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