The Effects of Local Injection of Simvastatin on Tooth Movement and Root Resorption Rates Under Orthodontic Forces in Dogs

Feizbakhsh, Masoud; Mortazavi, Mahsa; Razavi, Seyyed Mohammad; Hajhashemi, Valiollah

doi:10.13005/bbra/1350

Cited by 4 publications

(13 citation statements)

References 14 publications

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“…Consequently, five studies including a total number of 108 animals were included in the qualitative assessment (39)(40)(41)(42)(43), and three trials were considered in the quantitative analysis (40,41,43) (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

“…All the five included studies were randomized experimental trials (39)(40)(41)(42)(43), of which two cases had a split-mouth design (39,40). The other three trials used a parallel-arm design (41)(42)(43).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The q uality of evidence was evaluated using the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) tool (38). It addresses ten specific domains including peer-reviewed publication, control of temperature, random allocation to treatment or control, study was conducted on rabbits 39, and one study used dogs as animal models (42). The number of applied rats in trials ranged from 24 to 36.…”

Section: Quality Of Evidencementioning

confidence: 99%

“…Regarding the type of the Stains, three trials administered Simvastatin (SMV) (39,41,42) and the other two used atorvastatin (ATV) (40,43).…”

Section: Quality Of Evidencementioning

confidence: 99%

“…The studies used various modes of statin administration, including submucosal and intraligamentous injection (39), systemic (gavage) (40,43), intraperitoneal injection (41), and local injections (42).…”

Section: Quality Of Evidencementioning

confidence: 99%

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The Effect of Statins on Orthodontic Tooth Movements: A Meta-analysis of Animal Studies

Afshari

Tahamtan

Shirban

2021

Avicenna J Dent Res

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Background: Statins are effective therapeutic agents for the treatment of cardiovascular diseases. Their favorable effects on various aspects of oral health including promising effects on bone metabolism and pleiotropic impacts such as anti-inflammatory properties made these drugs a current area of interest in the field of orthodontics. Therefore, the aim of this study was to evaluate the effects of statins on orthodontic tooth movement (OTM) in animals undergoing orthodontic treatments. Methods: Several databases were comprehensively searched for studies measuring the effects of statins on the OTM up to January 2020, including MEDLINE, ISI Web of Science, EMBASE, Scopus, and Cochrane. Animal studies evaluating the effects of statins on tooth movements in animals undergoing orthodontic treatments were selected based on the PICO model .Study selection, data extraction, risk of bias, and study quality assessment were independently performed by two reviewers. Finally, the data were analyzed using random-effects meta-analysis and the mean difference (MD) was used for comparing the outcome measures. Results: Three randomized trials were finally included in this meta-analysis. According to the Systematic Review Centre for Laboratory animal Experimentation Tool, all the included studies had at least one domain at a high risk of bias. The amount of the OTM was insignificantly lower in the statin group (MD = 0.134 mm, %95 confidence interval = -0.020-0.288, P>0.05). Conclusions: Due to the low quality and methodological inconsistencies among the included studies, conclusive confirmation regarding the effect of statins on the OTM remains debatable. Trail Registration: The protocol of this study was registered on PROSPERO (https://www.crd.york.ac.uk/ PROSPERO/) with the ID # CRD42020164155.

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Section: Study Selectionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Quality Of Evidencementioning

confidence: 99%

“…Regarding the type of the Stains, three trials administered Simvastatin (SMV) (39,41,42) and the other two used atorvastatin (ATV) (40,43).…”

Section: Quality Of Evidencementioning

confidence: 99%

Section: Quality Of Evidencementioning

confidence: 99%

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The Effect of Statins on Orthodontic Tooth Movements: A Meta-analysis of Animal Studies

Afshari

Tahamtan

Shirban

2021

Avicenna J Dent Res

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Effect of statins on orthodontic tooth movement: A systematic review of animal and clinical studies

Kommuri

Javed

Akram

et al. 2020

Archives of Oral Biology

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The Use of Polymers to Enhance Post-Orthodontic Tooth Stability

2022

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Relapse after orthodontic treatment occurs at a rate of about 70 to 90%, and this phenomenon is an orthodontic issue that has not yet been resolved. Retention devices are one attempt at prevention, but they require a considerable amount of time. Most orthodontists continue to find it challenging to manage orthodontic relapse; therefore, additional research is required. In line with existing knowledge regarding the biological basis of relapse, biomedical engineering approaches to relapse regulation show promise. With so many possible uses in biomedical engineering, polymeric materials have long been at the forefront of the materials world. Orthodontics is an emerging field, and scientists are paying a great deal of attention to polymers because of their potential applications in this area. In recent years, the controlled release of bisphosphonate risedronate using a topically applied gelatin hydrogel has been demonstrated to be effective in reducing relapse. Simvastatin encapsulation in exosomes generated from periodontal ligament stem cells can promote simvastatin solubility and increase the inhibitory action of orthodontic relapse. Moreover, the local injection of epigallocatechin gallate-modified gelatin suppresses osteoclastogenesis and could be developed as a novel treatment method to modify tooth movement and inhibit orthodontic relapse. Furthermore, the intrasulcular administration of hydrogel carbonated hydroxyapatite-incorporated advanced platelet-rich fibrin has been shown to minimize orthodontic relapse. The objective of this review was to provide an overview of the use of polymer materials to reduce post-orthodontic relapse. The most promising polymeric materials and their potential orthodontic uses for the prevention of orthodontic relapse are also discussed.

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The Effects of Local Injection of Simvastatin on Tooth Movement and Root Resorption Rates Under Orthodontic Forces in Dogs

Cited by 4 publications

References 14 publications

The Effect of Statins on Orthodontic Tooth Movements: A Meta-analysis of Animal Studies

The Effect of Statins on Orthodontic Tooth Movements: A Meta-analysis of Animal Studies

Effect of statins on orthodontic tooth movement: A systematic review of animal and clinical studies

The Use of Polymers to Enhance Post-Orthodontic Tooth Stability

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