The effects of local vanadium treatment on angiogenesis and chondrogenesis during fracture healing

Paglia, David N.; Wey, Aaron; Park, Andrew G.; Breitbart, Eric A.; Mehta, Siddhant K.; Bogden, John D.; Kemp, Francis W.; Benevenia, Joseph; O’Connor, J. P.; Lin, Sheldon S.

doi:10.1002/jor.22159

Cited by 30 publications

(63 citation statements)

References 25 publications

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“…The study which relate organic form of vanadium and angiogenesis, declared that local administration of vanadyl acetylacetonate enhanced femur fracture healing in a nondiabetic BB Wistar rat model, suggesting that local administration of vanadyl acetylacetonate is a potential therapeutic strategy for fracture healing [139]. These results revealed that new blood vessels and VEGFc levels were remarkably increased in the fracture callus [139].…”

Section: Methodsmentioning

confidence: 99%

“…These results revealed that new blood vessels and VEGFc levels were remarkably increased in the fracture callus [139]. Although it was found that VEGF expression in mouse epidermal cells after exposure to vanadium (IV and V) was significantly increased [140], no other studies have investigated the effects of vanadium on blood vessel formation [139]. …”

Section: Methodsmentioning

confidence: 99%

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Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb)

Saghiri

Orangi²,

Asatourian³

et al. 2016

Critical Reviews in Oncology/Hematology

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Many essential elements exist in nature with significant influence on human health. Angiogenesis is vital to developmental, repair, and regenerative processes, and its aberrant regulation contributes to pathogenesis of many diseases including cancer. Thus, it is of great importance to explore the role of these elements in such a vital process. This is third in a series of reviews that serve as an overview of the role of inorganic elements in regulation of angiogenesis and vascular function. Here we will review the roles of titanium, lithium, cerium, arsenic, mercury, vanadium, niobium, and lead in these processes. The roles of other inorganic elements in angiogenesis were discussed in part I and part II of these series. The methods of exposure, structure, mechanisms, and potential activities of these elements are briefly discussed. An electronic search was performed on the role of these elements in angiogenesis from January 2005-April 2014. These elements can promote and/or inhibit angiogenesis through different mechanisms. The anti-angiogenic effect of titanium dioxide nanoparticles comes from the inhibition of angiogenic processes, and not from its toxicity. Lithium affects vasculogenesis but not angiogenesis. Nanoceria treatment inhibited tumor growth by inhibiting angiogenesis. Vanadium treatment inhibited cell proliferation and induced cytotoxic effects through interactions with DNA. The negative impact of Mercury on cell migration and tube formation activities was dose and time dependent. Lead induced IL-8 production, which is known to promote tumor angiogenesis. Thus, understanding the impact of these elements on angiogenesis will help in development of new modalities to modulate angiogenesis under various conditions.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb)

Saghiri

Orangi²,

Asatourian³

et al. 2016

Critical Reviews in Oncology/Hematology

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“…In a very different type of study, Paglia et al investigated the influence of local administration of VO(acac) 2 at the fracture site on bone healing in healthy, diabetic-resistant, male BB Wistar rats [110]. The results are illustrated in Figure 17 contrasting the progression of healing from 10 to 21 days post-fracture for saline-treated and VO(acac) 2 treated rats.…”

Section: Biological Action Of Vo2+-chelatesmentioning

confidence: 99%

The structural basis of action of vanadyl (VO2+) chelates in cells

Makinen

Salehitazangi

2014

Coordination Chemistry Reviews

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Much emphasis has been given to vanadium compounds as potential therapeutic reagents for the treatment of diabetes mellitus. Thus far, no vanadium compound has proven efficacious for long-term treatment of this disease in humans. Therefore, in review of the research literature, our goal has been to identify properties of vanadium compounds that are likely to favor physiological and biochemical compatibility for further development as therapeutic reagents. We have, therefore, limited our review to those vanadium compounds that have been used in both in vivo experiments with small, laboratory animals and in in vitro studies with primary or cultured cell systems and for which pharmacokinetic and pharmacodynamics results have been reported, including vanadium tissue content, vanadium and ligand lifetime in the bloodstream, structure in solution, and interaction with serum transport proteins. Only vanadyl (VO2+) chelates fulfill these requirements despite the large variety of vanadium compounds of different oxidation states, ligand structure, and coordination geometry synthesized as potential therapeutic agents. Extensive review of research results obtained with use of organic VO2+-chelates shows that the vanadyl chelate bis(acetylacetonato)oxidovanadium(IV) [hereafter abbreviated as VO(acac)2], exhibits the greatest capacity to enhance insulin receptor kinase activity in cells compared to other organic VO2+-chelates, is associated with a dose-dependent capacity to lower plasma glucose in diabetic laboratory animals, and exhibits a sufficiently long lifetime in the blood stream to allow correlation of its dose-dependent action with blood vanadium content. The properties underlying this behavior appear to be its high stability and capacity to remain intact upon binding to serum albumin. We relate the capacity to remain intact upon binding to serum albumin to the requirement to undergo transcytosis through the vascular endothelium to gain access to target tissues in the extravascular space. Serum albumin, as the most abundant transport protein in the blood stream, serves commonly as the carrier protein for small molecules, and transcytosis of albumin through capillary endothelium is regulated by a Src protein tyrosine kinase system. In this respect it is of interest to note that inorganic VO2+ has the capacity to enhance insulin receptor kinase activity of intact 3T3-L1 adipocytes in the presence of albumin, albeit weak; however, in the presence of transferrin no activation is observed. In addition to facilitating glucose uptake, the capacity of VO2+- chelates for insulin-like, antilipolytic action in primary adipocytes has also been reviewed. We conclude that measurement of inhibition of release of only free fatty acids from adipocytes stimulated by epinephrine is not a sufficient basis to ascribe the observations to purely insulin-mimetic, antilipolytic action. Adipocytes are known to contain both phosphodiesterase-3 and phosphodiesterase-4 (PDE3 and PDE4) isozymes, of which insulin antagonizes lipolysis only through...

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“…A biodegradable magnesium alloy has been studied for orthopedic applications [50] and has been shown to facilitate bone healing in clinical trials [51]. Furthermore, local delivery of vanadium and manganese chloride, both are insulin mimetics, has been shown to enhance bone fracture repair [52,53].…”

Section: Figmentioning

confidence: 99%

Sodium Tungstate for Promoting Mesenchymal Stem Cell Chondrogenesis

Khader

Sherman

Rameshwar

et al. 2016

Stem Cells and Development

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Articular cartilage has a limited ability to heal. Mesenchymal stem cells (MSCs) derived from the bone marrow have shown promise as a cell type for cartilage regeneration strategies. In this study, sodium tungstate (Na 2 WO 4 ), which is an insulin mimetic, was evaluated for the first time as an inductive factor to enhance human MSC chondrogenesis. MSCs were seeded onto three-dimensional electrospun scaffolds in growth medium (GM), complete chondrogenic induction medium (CCM) containing insulin, and CCM without insulin. Na 2 WO 4 was added to the media leading to final concentrations of 0, 0.01, 0.1, and 1 mM. Chondrogenic differentiation was assessed by biochemical analyses, immunostaining, and gene expression. Cytotoxicity using human peripheral blood mononuclear cells (PBMCS) was also investigated. The chondrogenic differentiation of MSCs was enhanced in the presence of low concentrations of Na 2 WO 4 compared to control, without Na 2 WO 4 . In the induction medium containing insulin, cells in 0.01 mM Na 2 WO 4 produced significantly higher sulfated glycosaminoglycans, collagen type II, and chondrogenic gene expression than all other groups at day 28. Cells in 0.1 mM Na 2 WO 4 had significantly higher collagen II production and significantly higher sox-9 and aggrecan gene expression compared to control at day 28. Cells in GM and induction medium without insulin containing low concentrations of Na 2 WO 4 also expressed chondrogenic markers. Na 2 WO 4 did not stimulate PBMC proliferation or apoptosis. The results demonstrate that Na 2 WO 4 enhances chondrogenic differentiation of MSCs, does not have a toxic effect, and may be useful for MSC-based approaches for cartilage repair.

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The effects of local vanadium treatment on angiogenesis and chondrogenesis during fracture healing

Cited by 30 publications

References 25 publications

Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb)

Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb)

The structural basis of action of vanadyl (VO2+) chelates in cells

Sodium Tungstate for Promoting Mesenchymal Stem Cell Chondrogenesis

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