The effects of long-term diabetes on the haematological and uterine indicators and their association with neonatal nephrogenesis counter-protected by camel milk: A time dependent study

Abstract

The novelty of this project is to describe how chronic diabetes altered the haematological and uterine indicators in a time dependent-manner that were reversed by camel milk (CM) therapy in pregnant and non-pregnant rat models. Fifty-four female rats were divided into three groups: Placebo (N), diabetic control (DC) and diabetic treated (DT) with CM at 40 ml/kg/24 h for 90 days. A single intact male was introduced into every group for mating at day 60 of the experiment. The sample collection was undertaken at day 30 and 60 of the non-pregnant rats and at day 90 immediately after parturition for the pregnant rats. At every collection, the dam’s blood, as well as the uteri and neonatal kidneys were collected and subjected to a paraffin tissue preparation technique for a histological evaluation. The data revealed that at day 30, the uterine endo- and myometrium remained unaffected by diabetes, but at day 60, a significant reduction in the uterine indicators from diabetes was observed. However, the CM restored the uterine histology in the DT. At 90 day, chronic diabetes showed (P < 0.05) a harmful effect on the pregnant uterus which was reversed (P < 0.05) by the CM. The RBC (red blood cell) indices, platelets, and leucocyte counts were severely affected by the diabetes and protected by the CM at every point of collection. The kidney tissues of the neonate rats, delivered by the dams, in the DC presented a significant (P < 0.05) shrinkage in the cortex and glomeruli while the CM potentially reversed these changes. These results will help to understand the chronic diabetes effects on the uterus and neonate’s renal genesis, and the role of camel milk in the management of chronic pre-gestational diabetes.

Quality characteristics and nutrient contents of Bactrian camel milk as determined by mid‐infrared spectroscopy

“…Accordingly, camel milk has high application value, especially as a substitute for hypoallergenic infant formula (Maryniak et al 2018). Furthermore, it exhibits anti-inflammation (Al-Omari et al 2019;Patel et al 2021), anti-hypertension, antidiabetes (Mudgil et al 2018) and anti-cancer activities (El-Kattawy et al 2021;Shi et al 2021) as well as having important medical value in the treatment of liver and kidney injury (Usman et al 2020;Dou et al 2022). Milk composition is an important indicator reflecting the quality of dairy products and the health status of dairy animals.…”

“…2021) as well as having important medical value in the treatment of liver and kidney injury (Usman et al . 2020; Dou et al . 2022).…”