The effects of low and high intraabdominal pressure on immune response during general anaesthesia

A Prospective Randomized Study of Systemic Inflammation and Immune Response After Laparoscopic Nissen Fundoplication Performed With Standard and Low-pressure Pneumoperitoneum

“…Therefore, although there are several studies of intraabdominal pressure and immune functions, 14,25,26,50,73 we could not find any effect of various degree of intraabdominal pressure during LNF. We aimed to show this effect by measuring the level of serum ILs and preferred to detect IL-1, which is one of the early systemic immune events after surgery, 15 and IL-6, which is one of the mediator of acute-phase response.…”

“…In the study conducted by Torres et al 25 (laparoscopic cholecystectomy performed with standard and low-pressure pneumoperitoneum), no differences were observed between the groups in regards to IL-6, IL-8, and IL-10 levels. Different results were presented by Basgul et al, 26 who revealed IL-6 p.o. levels to increase less in patients operated on with the implementation of low-pressure pneumoperitoneum.…”

“…15,16,[20][21][22][23][24] There have, however, been only few studies conducted that compared standard-pressure and low-pressure CO 2 pneumoperitoneum laparoscopy with respect to immune response. 25,26 Moreover, we could not find any effect of various degree of intraabdominal pressure during LNF. The aim of this prospective randomized study was to compare changes in the systemic inflammation and immune response in the early postoperative (p.o.)…”

Effects of low and standard intra-abdominal pressure on systemic inflammation and immune response in laparoscopic adrenalectomy: A prospective randomised study

“…[ 17 18 22 23 24 25 26 ] There have, however, been only a few studies conducted that compared standard-pressure and low-pressure CO 2 pneumoperitoneum laparoscopy with respect to immune response. [ 27 28 ] Moreover, we could not find any effect of various degrees of intra-abdominal pressure during LA. The aim of this prospective randomised study was to compare changes in the systemic inflammation and immune response in the early post-operative (p.o.)…”

A comparative study of angiogenic and cytokine responses after laparoscopic cholecystectomy performed with standard- and low-pressure pneumoperitoneum

“…The study by Kim et al, who measured serum concentrations of tumor necrosis factor (TNF)-a, IL-6, and IL-8, also showed that carbon dioxide pneumoperitoneum itself was capable of attenuating postoperative inflammatory response [12]. Different results were presented by Basgul et al, who revealed IL-6 postoperative levels to increase less in patients operated on with the implementation of low-pressure pneumoperitoneum [25].…”