The Effects of Low-Intensity Therapeutic Ultrasound on Measurable Outcomes: A Critically Appraised Topic

Daniels, Sarah; Santiago, Gabriela; Cuchna, Jennifer W.; Lunen, Bonnie Van

doi:10.1123/jsr.2016-0099

Cited by 6 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[24][25][26] The inconsistency of ultrasound treatment effectiveness cited in the literature and metanalysis can be attributed to a lack of optimization of ultrasound duty cycle, frequency, intensity, and power as well as patient compliance. [27][28][29] Over the last decade, research suggests daily increased energy deposition via low-intensity ultrasound can improve patients' quality of life. Low-intensity continuous ultrasound (LICUS) devices enable patients to self-apply non-invasive therapeutic ultrasound for up to four hours per day, increasing total energy deposition to almost 20,000 Joules compared to an ON/OFF 10 to 20-minute therapist applied ultrasound treatment, which typically involves 700 to 2,000 Joules of energy deposition once a week.…”

Section: Introductionmentioning

confidence: 99%

“…Recent literature reviews on LICUS have found the treatment is effective in decreasing pain and improving function in musculoskeletal injuries. 29 Additionally, ultrasound can have mechanical and biologically driven effects such as myoregeneration, 32 improve biomechanics, 31 anti-inflammatory, 39 and thermal effects. 33,34 The objective of this study was to determine the effectiveness of daily 4-hour LICUS at alleviating upper trapezius active myofascial pain and muscle tenderness over a 4-week treatment period.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial</p>

Petterson¹,

Plancher

Klyve

et al. 2020

JPR

View full text Add to dashboard Cite

Low-intensity continuous ultrasound (LICUS) is an emerging high-dosimetry ultrasound-based therapy for accelerated tissue healing and the treatment of myofascial pain. In this study, LICUS treatment is clinically evaluated for chronic upper neck and shoulder pain in a randomized, multi-site, double-blind, placebo-controlled study. Patients and Methods: CONSORT guidelines were followed in conducting and reporting the clinical trial. Thirty-three participants with upper trapezius myofascial pain were randomized for treatment with active (n=25) or placebo (n=8) devices. Investigators and subjects were blinded to treatment groups. Participants self-reported pain daily, rating from 0-10 on the numeric rating scale. If pain rating was more significant than or equal to 3, the LICUS (3MHz, 0.132W/cm 2 , 1.3W, 4 hours) was self-applied for total energy dosimetry of 18,720 Joules per treatment. During the 4-week study, daily pain rating was recorded. If LICUS treatment was delivered, pain before, during, and after treatment were recorded as well as the global rate of change (GROC). Independent t-tests were used to assess change from baseline and differences between treatment groups. ClinicalTrials.gov: NCT02135094. Results: There was a 100% completion rate for participants enrolled in the study and no significant differences between the groups regarding demographic variables or baseline outcome measures. Participants treated with active therapy observed a significant mean pain reduction from baseline of 2.61 points for active (p<0.001), compared to 1.58 points decrease from baseline for placebo (p=0.087), resulting in a 1.03 points significant decrease in the active group over placebo (p=0.003). The total GROC was significantly higher in the active group at 2.84 points compared to the placebo group at 0.46 points (p<0.001). Conclusion: Low-intensity continuous ultrasound treatment significantly reduced pain in patients with upper trapezius myofascial pain of the neck and shoulder. LICUS treatment showed a clinically meaningful improvement in the GROC scores for patients. The results from this clinical trial indicate that the LICUS treatment of 18,720 Joules can effectively be used to treat clinical pain related to upper trapezius myofascial pain. Further research could investigate varying dosimetry to improve efficacy and/or reduce the dose.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial</p>

Petterson¹,

Plancher

Klyve

et al. 2020

JPR

View full text Add to dashboard Cite

show abstract

“…The mechanical effect can regulate the cell membrane, increase protein synthesis, increase cell migration, promote vascular regeneration, and adjust the inflammatory response. Thermal responses include increased cell metabolism, improved local blood circulation, reduced pain, and alleviated muscle spasms . Esenyel et al used planar pulsed ultrasound for the treatment of 102 patients with neck and shoulder muscle pain, of whom 22.9% had significant pain alleviation after treatment.…”

Section: Discussionmentioning

confidence: 99%

Alleviation Effects and Mechanisms of Low‐intensity Focused Ultrasound on Pain Triggered by Soft Tissue Injury

Liang

Chen

Zhou

et al. 2019

J of Ultrasound Medicine

View full text Add to dashboard Cite

Objectives-Pain caused by soft tissue injury (STI) is always intractable and will eventually result in physical and psychological problems. This experiment aimed to assess the efficacy and mechanisms of low-intensity focused ultrasound (LIFU) for pain-related STI.Methods-Rabbits (n = 30) with STI were given fixed treatment for 20 seconds and then mobile treatment for 60 seconds daily for 10 consecutive days by an LIFU device with a power output of 5 to 6 W and a frequency of 0.8 MHz. To evaluate the degree of pain, the levels of β-endorphin in serum were measured by an enzyme-linked immunosorbent assay before and 5 to 10 minutes after the 1st, 3rd, 7th, and 10th treatments. The pain threshold was measured by an electronic analgesy meter on the 1st, 3rd, 7th, 10th, 17th, and 24th days after the start of the treatment. To investigate inflammation, prostaglandin E 2 , interleukin-1β, and 5-hydroxytryptamine levels were detected by an enzyme-linked immunosorbent assay, and nuclear factor κB messenger RNA levels were determined by a real-time quantitative polymerase chain reaction at the same time as the pain threshold was tested.Results-Compared with non-LIFU groups, β-endorphin levels and pain thresholds were significantly increased (P < .05), whereas nuclear factor-κB messenger RNA, prostaglandin E 2 , interleukin-1β, and 5-hydroxytryptamine levels were significantly reduced (P < .05) after LIFU treatment in rabbits with STI.Conclusions-Low-intensity focused ultrasound can alleviate pain induced by STI and could have further clinical applications.

show abstract

“…This limitation was beyond the scope of this research but could be considered in a future analysis paying close attention to time, duration, dose delivered and regularity of ultrasound treatment. The literature search strategy we employed found 13 relevant articles specific to SAM that are more than other past reviews on Sustained Acoustic Medicine ever, it is possible that some relevant studies were missed that were not available in English language or those in the grey literature which are emerging on this new therapeutic treatment [ 79 , 92 , 93 ]. Additionally, several of the outcome variables used in the studies differed in both measure, physical location on the body, condition being treated and control group which limited the scope of meta-analysis.…”

Section: Limitationsmentioning

confidence: 99%

Sustained acoustic medicine for the treatment of musculoskeletal injuries: a systematic review and meta-analysis

Winkler

Urbisci

Best

2021

BMC Sports Sci Med Rehabil

View full text Add to dashboard Cite

Background Musculoskeletal injuries account for 10 million work-limited days per year and often lead to both acute and/or chronic pain, and increased chances of re-injury or permanent disability. Conservative treatment options include various modalities, nonsteroidal anti-inflammatory drugs, and physical rehabilitation programs. Sustained Acoustic Medicine is an emerging prescription home-use mechanotransductive device to stimulate cellular proliferation, increase microstreaming and cavitation in situ, and to increase tissue profusion and permeability. This research aims to summarize the clinical evidence on Sustained Acoustic Medicine and measurable outcomes in the literature. Methods A systematic literature review was conducted using PubMed, EBSCOhost, Academic Search Complete, Google Scholar and ClinicalTrials.gov to identify studies evaluating the effects of Sustained Acoustic Medicine on the musculoskeletal system of humans. Articles identified were selected based on inclusion criteria and scored on the Downs and Black checklist. Study design, clinical outcomes and primary findings were extracted from included studies for synthesis and meta-analysis statistics. Results A total of three hundred and seventy-two participants (372) were included in the thirteen clinical research studies reviewed including five (5) level I, four (4) level II and four (4) level IV studies. Sixty-seven (67) participants with neck and back myofascial pain and injury, one hundred and fifty-six (156) participants with moderate to severe knee pain and radiographically confirmed knee osteoarthritis (Kellgren–Lawrence grade II/III), and one hundred forty-nine (149) participants with generalized soft-tissue injury of the elbow, shoulder, back and ankle with limited function. Primary outcomes included daily change in pain intensity, change in Western Ontario McMaster Osteoarthritis Questionnaire, change in Global Rate of Change, and functional outcome measures including dynamometry, grip strength, range-of-motion, and diathermic heating (temperature measurement). Conclusion Sustained Acoustic Medicine treatment provides tissue heating and tissue recovery, improved patient function and reduction of pain. When patients failed to respond to physical therapy, Sustained Acoustic Medicine proved to be a useful adjunct to facilitate healing and return to work. As a non-invasive and non-narcotic treatment option with an excellent safety profile, Sustained Acoustic Medicine may be considered a good therapeutic option for practitioners.

show abstract

The Effects of Low-Intensity Therapeutic Ultrasound on Measurable Outcomes: A Critically Appraised Topic

Cited by 6 publications

References 6 publications

<p>Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial</p>

<p>Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial</p>

Alleviation Effects and Mechanisms of Low‐intensity Focused Ultrasound on Pain Triggered by Soft Tissue Injury

Sustained acoustic medicine for the treatment of musculoskeletal injuries: a systematic review and meta-analysis

Contact Info

Product

Resources

About