The effects of low-level laser therapy on xerostomia (mouth dryness)

Pavlić, Verica

doi:10.2298/mpns1206247p

Cited by 13 publications

(6 citation statements)

References 22 publications

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“…Although there are many available treatment modalities to enhance salivary flow, the therapy often remains unsatisfactory. PBM has been extensively used as a new advantageous tool for the reduction of xerostomia …”

Section: Role Of Photobiomodulation In Oral Medicinementioning

confidence: 99%

Photobiomodulation in oral medicine: a review

Pandeshwar

Roa

Das

et al. 2015

J of Invest & Clin Dent

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Photobiomodulation (PBM) or low-level laser therapy (LLLT) in dentistry is an evolving science, with an increasing number of controlled clinical studies exploring its potential as a treatment modality. The present study provides an outline of the biologic mechanism of PBM and summarizes the findings of clinical studies of PBM for specific applications in oral medicine. Controversies and drawbacks associated with PBM, which require further research, are also identified. Current literature reports the potential of PBM in various applications in oral medicine. Furthermore, well-documented research confirms its efficacy in certain conditions, such as oral mucositis, recurrent herpes simplex infection, and burning mouth syndrome. The absence of any reported adverse effects is an advantage over conventional therapeutic modalities. While PBM has proved to be effective for some specific applications, it is not a panacea. The paucity in standardized studies, coupled with ambiguity over the laser parameters, has limited its credibility as a therapeutic modality.

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Section: Role Of Photobiomodulation In Oral Medicinementioning

confidence: 99%

Photobiomodulation in oral medicine: a review

Pandeshwar

Roa

Das

et al. 2015

J of Invest & Clin Dent

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show abstract

“…Although numerous published studies have focused on the role of RAGE and its ligands in diabetes, little is known about the expression of AGE, HMGB1 and RAGE in diabetic submandibular glands (SMGs), as well as the effects of diabetes on apoptosis and proliferation markers in that tissue. Furthermore, in the last decade, low-power laser therapy (LPLI) has been applied clinically for the treatment of hyposalivation [17–20]. Our group previously reported that LPLI increases salivary flow of irradiated rat salivary glands [21] and improves the antioxidant enzyme activities of superoxide dismutase and catalase in SMGs of diabetic rats [22].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Low-Power Laser Irradiation on Inflammation and Apoptosis in Submandibular Glands of Diabetes-Induced Rats

et al. 2017

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Diabetes can lead to dysfunction of the secretory capacity in salivary glands. Activation of the receptor for advanced glycation end products (RAGE) and its ligands has been suggested to participate in chronic disorders such as diabetes and its complications. In this study, the expression of RAGE, high mobility group box 1 (HMGB1) and advanced glycation end products (AGE), as well as the effects of low-power laser irradiation (LPLI) in salivary glands of diabetic rats were evaluated, and the mechanisms involved were characterized. The expression of RAGE and HMGB1 at the protein and mRNA levels was observed in submandibular glands (SMGs) of streptozotocin-induced diabetic rats. A diode laser was applied at 660 nm, 70 mW, 20 J/cm2, 0.56 J/point, with a spot area of 0.028 cm2 and its in vivo effects and the pathways involved were evaluated. Immunohistochemistry and western blotting analysis were performed for inflammatory and apoptosis markers. Diabetes up-regulates HMGB1/AGE/RAGE axis gene expression in SMGs that is associated with activation of the nuclear factor kappa B (NF-κB) pathway. Interestingly, LPLI suppresses NF-κB activation induced by inflammation. LPLI also reduces diabetes-induced apoptosis. That effect was accompanied by decreased levels of Bax, and cleaved caspase 3, which were up-regulated in diabetes. Taken together, our data suggest that LPLI reduces diabetes-induced inflammation by reducing the induction of HMGB1, ultimately leading to inhibition of apoptosis in submandibular glands of diabetic rats.

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“…Moreover, one study stated that the effects of LLLT on salivary glands are not only motivating, but also restore the glandular response to the same quantity of applied laser therapy (26) . Another study found that LLLT could markedly increase salivary excretion and ameliorate antimicrobial features of secreted saliva (elevated level of sIgA) (27) .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Therapeutic Role of the Low Level Laser on the Gamma Irradiated Teeth and the Antimicrobial Salivary Biomarkers in Rat’s Model: an Experimental Study

2021

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The aim of the study was to examine the impact of Low-level laser therapy (LLLT) on gamma-irradiated teeth regarding tooth structure hardness, salivary pH and salivary IgA. Material and Methods: Thirty adult male albino rats were separated into three groups, which were control group, irradiated group (animals irradiated with a dose of 6 Gy) and gamma irradiated + Laser (the rats wear exposed to low level laser after three days of gamma radiation). Results: The obtained results revealed that the combination group (Gamma + Laser) recorded the highest salivary IgA followed by Control group while Gamma group recorded the lowest salivary IgA. Also, it was found that the Control group recorded the highest salivary pH followed by the combination group while Gamma group recorded the lowest salivary pH. The combination group (Gamma + Laser) recorded the highest tooth hardness followed by Gamma group while the control group recorded the lowest tooth hardness. Conclusion: With the limitations of this study, it was conducted that the Low-level laser therapy post gamma irradiation reflected a significant increase in salivary pH, salivary IgA and tooth hardness compared to both the control and the gamma-irradiated groups.

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The effects of low-level laser therapy on xerostomia (mouth dryness)

Cited by 13 publications

References 22 publications

Photobiomodulation in oral medicine: a review

Photobiomodulation in oral medicine: a review

The Effects of Low-Power Laser Irradiation on Inflammation and Apoptosis in Submandibular Glands of Diabetes-Induced Rats

Evaluation of the Therapeutic Role of the Low Level Laser on the Gamma Irradiated Teeth and the Antimicrobial Salivary Biomarkers in Rat’s Model: an Experimental Study

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