The Effects of Low-level Pb on Steroidogenic Acute Regulatory Protein (StAR) in the Prepubertal Rat Ovary

Srivastava, Vinod K.

doi:10.1093/toxsci/kfg249

Cited by 29 publications

(10 citation statements)

References 33 publications

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“…Evidence suggests that lead affects the hypothalamic–pituitary–gonadal axis by diminishing expression of the steroidogenic acute regulatory protein gene (Srivastava et al 2004). Further, lead exposure to ovarian granulosa cells induces peptides related to proliferation (cyclin B1) and apoptosis (caspace-3) (Kolesarova et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Cadmium, Lead, and Mercury in Relation to Reproductive Hormones and Anovulation in Premenopausal Women

Pollack

Schisterman

Goldman

et al. 2011

Environ Health Perspect

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Background: Metals can interfere with hormonal functioning by binding at the receptor site and through indirect mechanisms; thus, they may be associated with hormonal changes in premenopausal women.Objectives: We examined the associations between cadmium, lead, and mercury, and anovulation and patterns of reproductive hormones [estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone] among 252 premenopausal women 18–44 years of age who were enrolled in the BioCycle Study in Buffalo, New York.Methods: Women were followed for up to two menstrual cycles, with serum samples collected up to eight times per cycle. Metal concentrations were determined at baseline in whole blood by inductively coupled mass spectroscopy. Marginal structural models with stabilized inverse probability weights and nonlinear mixed models with harmonic terms were used to estimate the effects of cadmium, lead, and mercury on reproductive hormone levels during the menstrual cycle and anovulation.Results: Geometric mean (interquartile range) cadmium, lead, and mercury levels were 0.29 (0.19–0.43) μg/L, 0.93 (0.68–1.20) μg/dL, and 1.03 (0.58–2.10) μg/L, respectively. We observed decreases in mean FSH with increasing cadmium [second vs. first tertile: –10.0%; 95% confidence interval (CI), –17.3% to –2.5%; third vs. first tertile: –8.3%; 95% CI, –16.0% to 0.1%] and increases in mean progesterone with increasing lead level (second vs. first tertile: 7.5%; 95% CI, 0.1–15.4%; third vs. first tertile: 6.8%; 95% CI, –0.8% to 14.9%). Metals were not significantly associated with anovulation.Conclusions: Our findings support the hypothesis that environmentally relevant levels of metals are associated with modest changes in reproductive hormone levels in healthy, premenopausal women.

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Section: Discussionmentioning

confidence: 99%

Cadmium, Lead, and Mercury in Relation to Reproductive Hormones and Anovulation in Premenopausal Women

Pollack

Schisterman

Goldman

et al. 2011

Environ Health Perspect

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“…Lead is shown to cause reduction in the expression of the steroidogenic acute regulatory protein (StAR), inhibition of LH secretion (Srivastava et al, 2004), increase in lipid peroxidation and ROS production (Kasperczyk et al, 2008;Hsu, Hsu, Liu, Chen, & Guo, 1998). In vivo exposure to lead suppressed circulating LH, FSH and estradiol without affecting progesterone in cynomolgus monkey (Foster, 1992).…”

Section: Discussionmentioning

confidence: 99%

Untitled

Gautam¹,

Chaube²

2018

Turk. J. Fish. Aquat. Sci.

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The aim of the present study was to examine comparative effects of different concentrations of heavy metals such as cadmium (Cd), cobalt (Co), lead (Pb) and mercury (Hg) on catfish oocyte maturation and ovulation. Post-vitellogenic oocytes of the catfish H. fossilis were incubated with heavy metals at concentrations of 0.1, 1.0, 10 and 50ng/ml. Translucent follicles without germinal vesicle and opaque follicles with GV were scored after 4, 8, 16, and 24 hr of incubation. Percentage GV breakdown (GVBD) was calculated as an index of oocyte maturation. The results of present investigation suggested that the effect of heavy metals on oocyte maturation and ovulation was in the order of Pb > Hg >Cd>Co. Pb and Hg showed significant increases (P<0.05) in GVBD and ovulation at all concentrations during 4 and 8hr of the incubation. However, there was a dose -dependent decrease at 16 and 24hr. Cd and Co showed decline in GVBD and ovulation at 16 and 24 hr of the incubation. However, mercury and lead showed a stimulatory effect on ovulation at 16 and 24 hr compared to control (P<0.05). Thus, these results suggest that catfish oocytes are differentially influenced by heavy metals and are resistant to them at certain levels.

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“…Lead may alter hormonal expression via effects to the steroidogenic acute regulatory protein gene. (Srivastava, Dearth, Hiney, Ramirez, Bratton, and Dees, 2004) Animal studies also show accumulation of lead in the ovary leading to altered folliculogenesis in mice (Taupeau, Poupon, Nome, and Lefevre, 2001)and longer, irregular cycles in exposed Rhesus monkeys. (Laughlin et al , 1987)…”

Section: Discussionmentioning

confidence: 99%

Menopause and lead body burden among US women aged 45–55, NHANES 1999–2010

Mendola¹,

Brett

DiBari

et al. 2013

Environmental Research

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Background Environmental factors in menopause have received limited attention. Lead is a known reproductive toxicant associated with delayed puberty in girls that may also affect menopause. Methods The odds of menopause among US women aged 45–55 were estimated in the National Health and Nutrition Examination Survey, 1999–2010, in relation to quartiles of blood lead. Women still menstruating (n=2158) were compared to women with natural menopause (n=1063). Logistic regression models included age, race/ethnicity, current hormone use, poverty, smoking and where available, bone density or bone alkaline phosphatase. Results Lead levels (ug/dL) were higher in menopausal women, geometric mean (standard error) = 1.71 (0.04) vs. 1.23 (0.02). Adjusted odds of menopause and 95% confidence intervals for lead quartiles (lowest quartile referent) were 1.7 (1.0–2.8), 2.1 (1.2–3.6), and 4.2 (2.5–7.0) respectively. Results adjusting for bone markers were generally similar but had less precision. Conclusions Blood lead was associated with natural menopause in US women even after adjustment for bone turnover. This raises concern that lead exposure, even at low levels, may shorten women’s reproductive lifespan.

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The Effects of Low-level Pb on Steroidogenic Acute Regulatory Protein (StAR) in the Prepubertal Rat Ovary

Cited by 29 publications

References 33 publications

Cadmium, Lead, and Mercury in Relation to Reproductive Hormones and Anovulation in Premenopausal Women

Cadmium, Lead, and Mercury in Relation to Reproductive Hormones and Anovulation in Premenopausal Women

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Menopause and lead body burden among US women aged 45–55, NHANES 1999–2010

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