The effects of mammalian target of rapamycin inhibitors on serum uric acid levels in renal transplant patients

Güngör, Özkan; Tanrısev, Mehmet; Kırçelli, Fatih; Turan, Mehmet; Tuğmen, Cem; Tatar, Erhan; Töz, Hüseyin

doi:10.1007/s11255-012-0214-0

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Molecular Pathways and Pharmacological Agents1

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Cited by 2 publications

(2 citation statements)

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“…The mechanism underlying this NH 4 + -independent acidification response is not clear and requires further investigation. The higher serum uric acid found in the tacrolimus vs. the sirolimus group was expected [14] and may be implicated in reduced graft survival [15]. Fractional excretion of calcium was higher in the tacrolimus patients with dRTA and, although expected, was not detected in the sirolimus patients with the same condition.…”

Section: Discussionmentioning

confidence: 85%

Tubular dysfunction in renal transplant patients using sirolimus or tacrolimus

Banhara¹,

Gonçalves²,

Rocha³

et al. 2015

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Section: Discussionmentioning

confidence: 85%

Tubular dysfunction in renal transplant patients using sirolimus or tacrolimus

Banhara¹,

Gonçalves²,

Rocha³

et al. 2015

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“…The effects of the mTOR inhibitor rapamycin (Sirolimus) on serum uric acid levels were studied in renal transplant patients. Immunosuppressive therapy with calcineurin inhibitors elevated uric acid levels, whereas the switch to a Sirolimus-based regimen reversed the rise in serum uric acid levels in these patients [51]. These results, albeit indirectly, suggest that inhibition of the mTOR pathway is important for reducing XOR activity.…”

Section: Molecular Pathways and Pharmacological Agentsmentioning

confidence: 89%

Pro-Aging Effects of Xanthine Oxidoreductase Products

et al. 2020

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The senescence process is the result of a series of factors that start from the genetic constitution interacting with epigenetic modifications induced by endogenous and environmental causes and that lead to a progressive deterioration at the cellular and functional levels. One of the main causes of aging is oxidative stress deriving from the imbalance between the production of reactive oxygen (ROS) and nitrogen (RNS) species and their scavenging through antioxidants. Xanthine oxidoreductase (XOR) activities produce uric acid, as well as reactive oxygen and nitrogen species, which all may be relevant to such equilibrium. This review analyzes XOR activity through in vitro experiments, animal studies and clinical reports, which highlight the pro-aging effects of XOR products. However, XOR activity contributes to a regular level of ROS and RNS, which appears essential for the proper functioning of many physiological pathways. This discourages the use of therapies with XOR inhibitors, unless symptomatic hyperuricemia is present.

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The effects of mammalian target of rapamycin inhibitors on serum uric acid levels in renal transplant patients

Abstract: Switch from CNI to mTORi-based regimen provides better control of UA levels and improves renal functions.

Cited by 2 publications

References 34 publications

Tubular dysfunction in renal transplant patients using sirolimus or tacrolimus

Tubular dysfunction in renal transplant patients using sirolimus or tacrolimus

Pro-Aging Effects of Xanthine Oxidoreductase Products

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