The effects of maternal age and parity on maternal and neonatal outcome

Schimmel, Michael S.; Bromiker, Ruben; Hammerman, Cathy; Chertman, Lila; Ioscovich, Alexander; Granovsky-Grisaru, Sorina; Samueloff, Arnon; Elstein, Deborah

doi:10.1007/s00404-014-3469-0

Cited by 133 publications

(134 citation statements)

References 36 publications

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“…[14][15][16] This finding is also similar to that of a previous study using the same primiparous model, 4 which reported that the aORs of LBW <2,500 g and PTB before 37 weeks were significantly increased in the 30-34-, 35-39-, and ≥40-year age groups. However, since we analyzed a larger number of participants and included psychological distress, measured using the K6 score, in logistic model than in that study, the aOR of PTB before 37 weeks and LBW <2,500 g in each age group was similar but the aOR of LBW <1,500 g became higher in our study.…”

Section: Discussionsupporting

confidence: 88%

The Effect of Maternal Age at the First Childbirth on Gestational Age and Birth Weight: The Japan Environment and Children’s Study (JECS)

Kyozuka

Fujimori

Hosoya

et al. 2019

Journal of Epidemiology

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Background: In Japan, mean maternal age at first childbirth is increasing. The aim of this study was to investigate whether maternal age at the first childbirth is a risk factor for preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). Methods: We used the results of Japan Environment and Children's Study (JECS) who gave birth in 2011-2014. Cases of primiparous singleton pregnancies where the subject was ≥20 years and delivered after 22 weeks were included. All subjects were categorized into five groups according to maternal age: 20-24, 25-29, 30-34, 35-39, and ≥40 years. Adjusted odds ratios (aORs) for PTB (before 37 and 34 weeks), LBW (<2,500 g and <1,500 g), and SGA were calculated using a logistic regression model, with the 20-24-year age group as reference. Results: We analyzed 38,412 singleton primiparous pregnancies. The aORs of all outcomes increased in parallel with each maternal age group >30 years. The aORs of PTB before 37 and 34 weeks, LBW <2,500 g, LBW <1,500 g, and SGA in the 30-34-year age group were 1. Conclusion:The present study showed that higher maternal age (>30 years) at the first childbirth was an independent risk factor for PTB, LBW, and SGA.

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Section: Discussionsupporting

confidence: 88%

The Effect of Maternal Age at the First Childbirth on Gestational Age and Birth Weight: The Japan Environment and Children’s Study (JECS)

Kyozuka

Fujimori

Hosoya

et al. 2019

Journal of Epidemiology

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“…Since both maternal age and parity correlate with higher birth weight, LGA rate, and other maternal pathology, such as hypertension or placenta previa [3,[36][37][38][39] we matched the controls to the study groups in order to exclude the possible bias. According to Lintsen et al, the impact of smoking on the live birth rate in IVF treatment is comparable with an increase in female age of >10 years in young women [40].…”

Section: Discussionmentioning

confidence: 99%

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Korošec

Frangež

Steblovnik

et al. 2015

J Assist Reprod Genet

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Purpose Higher risk for birth of singletons being large for gestational age (LGA) has been revealed after in vitro fertilization (IVF) frozen-thawed embryo-transfer (FET). This phenomenon is now being investigated, since there is a speculation that these neonates could suffer from underlying epigenetic disturbances. The aim of the study was to expose independent LGA risk factors and to identify those connected to the IVF techniques. Methods Altogether, 4508 singleton pregnancies and births were included in the cohort case-matched study. Two hundred eleven singleton pregnancies and births after FET and 916 after fresh embryo transfer (ET) were included into two study groups. The IVF procedures were performed at the University Medical Centre Ljubljana between 2004 and 2011. For each IVF pregnancy, three matched consecutive controls after natural conception were included. Using logistic regression models, we observed LGA connection to maternal parameters (smoking, hypertension, parity, BMI, gestational diabetes, IVF conception, FET, double ET, and ICSI procedure).Results Singletons born after FET had a significantly higher risk for being LGA (p=0.032; OR 1.697; 95 % CI 1.047-2.752). BMI 25-30 was a significant independent risk factor for LGA in the IVF groups (FET p=0.041, OR 2.460, 95 % CI 1.030-5.857 and fresh ET p=0.003; OR 2.188, 95 % CI 1.297-3.691). ICSI and double ET had no significant effect on LGA occurrence. Conclusions Besides maternal BMI, FET is a significant independent LGA risk factor in IVF patients. Other observed factors (smoking, hypertension, multiparity, GDM, ICSI procedure, or number of embryos transferred) do not influence LGA risk significantly.

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“…As well as the risks of ovarian stimulation and oocyte collection, studies are consistent as to the increase in perinatal (pre-eclampsia, maternal hypertension, preterm labour, perinatal mortality) and maternal risks (operative delivery and maternal morbidity and mortality) with advanced maternal age at delivery (50 years and 3 months in this case [15][16][17][18]). Specifically assessing the more extremes of maternal age, Laopaiboon et al [15] demonstrated adjusted odds ratios of 3.7 for a severe maternal adverse outcome (defined as a maternal death or a maternal near-miss up to 7 days after giving birth) and 1.6, 1.9 and 2.1 for a low Apgar score at delivery, perinatal mortality and stillbirth in women 45 or over at delivery.…”

Section: Discussionmentioning

confidence: 65%

“…Specifically assessing the more extremes of maternal age, Laopaiboon et al [15] demonstrated adjusted odds ratios of 3.7 for a severe maternal adverse outcome (defined as a maternal death or a maternal near-miss up to 7 days after giving birth) and 1.6, 1.9 and 2.1 for a low Apgar score at delivery, perinatal mortality and stillbirth in women 45 or over at delivery. Schimmel et al [16] demonstrated a significant increase in maternal hypertension (7.3 vs. 4.7 %), maternal diabetes (11.7 vs. 1.2 %), emergency operative delivery (0.9 vs. 0.3 %) and preterm delivery (5.2 vs. 4.0 %) in those between 43 and 47 compared to those 24-27. Data from the EUROCAT registries of congenital anomaly demonstrate that although overall congenital anomalies increase with age, there is no significant increase in nonchromosomal anomalies [19].…”

Section: Discussionmentioning

confidence: 98%

Treatment and preservation at the extremes of reproductive age: a case report outlining the ethical dilemmas

Nicopoullos

Wren

Abdalla

2015

J Assist Reprod Genet

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Purpose The purpose of the study was to report a livebirth from a cryopreserved embryo created from autologous oocytes collected at 47 years and 9 months that outlines the ethical difficulties of decision-making at the extreme of reproductive age. Methods The method used was IVF and embryo cryopreservation within an assisted conception unit prior to adjuvant cancer treatment in a nulliparous patient diagnosed with breast carcinoma (47 years and 9 months at oocyte collection). Results A 47-year-old nulliparous woman was diagnosed with breast malignancy during work-up for fertility treatment. Ovarian stimulation yielded one embryo from four oocytes that was cryopreserved to allow completion of adjuvant treatment. Subsequent embryo transfer cycle led to a live birth of a healthy baby girl at term, weighing 3.37 kg. Conclusion This paper demonstrates the oldest reported age of autologous oocyte collection to have achieved a livebirth. In women where most would consider treatment futile, we highlight the difficulties in decision-making in this group of patients.

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The effects of maternal age and parity on maternal and neonatal outcome

Abstract: AMA, especially primiparous, has more adverse maternal and neonatal outcomes than younger women; however, these did not include mortality. Consistent antenatal care may explain this.

Cited by 133 publications

References 36 publications

The Effect of Maternal Age at the First Childbirth on Gestational Age and Birth Weight: The Japan Environment and Children’s Study (JECS)

The Effect of Maternal Age at the First Childbirth on Gestational Age and Birth Weight: The Japan Environment and Children’s Study (JECS)

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Treatment and preservation at the extremes of reproductive age: a case report outlining the ethical dilemmas

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