The effects of maternal brucellosis on pregnancy outcome

Elshamy, Maged; Ahmed, Amien I.

doi:10.3855/jidc.268

Cited by 59 publications

(91 citation statements)

References 22 publications

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“…This association is disputed in peer-reviewed literature [47,48]. However, multiple studies hold that there is a true association between brucellosis infection and spontaneous abortions and fetal deaths [47,49–52]. This association could be explained by maternal toxemia, disseminated intravascular coagulation, or simply bacteremia.…”

Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

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Comparisons of brucellosis between human and veterinary medicine

Hull

Schumaker

2018

Infection Ecology & Epidemiology

151

129

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Brucellosis is the world’s most widespread zoonosis, but also ranks as one of the seven most neglected diseases, according to the World Health Organization. Additionally, it is recognized as the world’s most common laboratory-acquired infection. There are a reported 500,000 incident cases of human brucellosis per year. However, true incidence is estimated to be 5,000,000 to 12,500,000 cases annually. Once diagnosed, focus is directed at treating individual patients with antibiotic regimes, yet overall neglecting the animal reservoir of disease. Countries with the highest incidence of human brucellosis are Syria (1,603.4 cases per 1,000,000 individuals), Mongolia (391.0), and Tajikistan (211.9). Surveillance on animal populations is lacking in many developed and developing countries. According to the World Animal Health Information Database, Mexico had the largest number of reported outbreaks, 5,514 in 2014. Mexico is followed by China (2,138), Greece (1,268), and Brazil (1,142). The majority of these outbreaks is Brucella abortus, the etiologic agent of bovine brucellosis. Brucellosis is an ancient disease that still plagues the world. There are still knowledge gaps and a need for better diagnostics and vaccines to make inroads towards control and eradication.

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Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

“…Spontaneous abortion and fetal death was statistically associated with seropositivity. However, there was no increased risk for preterm labor in brucellosis-infected mothers [49,51]. …”

Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

Comparisons of brucellosis between human and veterinary medicine

Hull

Schumaker

2018

Infection Ecology & Epidemiology

151

129

View full text Add to dashboard Cite

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“…It is well established that a number of zoonotic pathogens, including Toxoplasma gondii, Listeria monocytogenes, certain Chlamydia species, and Coxiella burnetii, may constitute a risk for the pregnant woman and her fetus [1][2][3][4][5][6][7]. By contrast, pregnancy outcome following other zoonotic infections including Salmonella, Campylobacter, Yersinia enterocolitica and Brucella is more sparsely described [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Risk of adverse pregnancy outcome in women exposed to livestock: a study within the Danish National Birth Cohort

et al. 2013

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SUMMARYMaternal infection in pregnancy is a known risk factor for adverse pregnancy outcome, and a number of zoonotic pathogens may constitute a risk to pregnant women and their fetuses. With animal contact as a proxy for the risk of zoonotic infection, this study aimed to evaluate pregnancy outcome in women with self-reported occupational or domestic contact with livestock compared to pregnant women without such contact. The Danish National Birth Cohort collected information on pregnancy outcome from 100 418 pregnant women (1996)(1997)(1998)(1999)(2000)(2001)(2002) from which three study populations with occupational and/or domestic exposure to livestock and a reference group of women with no animal contact was sampled. Outcome measures were miscarriage, very preterm birth (before gestational week 32), preterm birth (before 37 gestational weeks), small for gestational age (SGA), and perinatal death. Adverse reproductive outcomes were assessed in four different exposure groups of women with occupational or domestic exposure to livestock with no association found between exposure to livestock and miscarriage, preterm birth, SGA or perinatal death. These findings should diminish general occupational health concerns for pregnant women with exposures to a range of different farm animals.

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“…Brucella seropositivity is not more common in women with spontaneous abortion or miscarriage than in women with uncomplicated pregnancies [141,142]. Some studies have shown that there is no correlation between the magnitude of Brucella agglutination titer and the occurrence of spontaneous abortion while others have shown that Brucella titers higher than 1:160 are associated with higher probability of spontaneous abortion [38, 130,136,143].…”

Section: Brucellosis In Pregnancymentioning

confidence: 99%

“…Occasionally, it may be complicated by Brucella bacteremia, septic shock, neurobrucellosis and disseminated intravascular coagulation (DIC) [131,132]. Brucellosis in pregnancy may predispose to spontaneous abortion, intrauterine fetal death, premature delivery, low birth weight in addition to postpartum intrauterine infections [1,130,[133][134][135][136][137][138][139]. Vaginal bleeding at presentation may be an early sign of spontaneous abortion.…”

Section: Brucellosis In Pregnancymentioning

confidence: 99%