The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina

Haybar, Habib; Javid, Ahmad Zare; Haghighizadeh, Mohammad Hosein; Valizadeh, Einollah; Mohaghegh, Seyede Marjan; Mohammadzadeh, A

doi:10.1016/j.clnesp.2018.04.015

Cited by 68 publications

(56 citation statements)

References 20 publications

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“…reported that MO decreased immobility time in the FST acute model through modulation of the serotonergic system (Lin et al., 2015). A clinical trial also reported that 8 weeks’ administration of MO markedly attenuated stress, anxiety, depression and insomnia (Haybar et al., 2018). To the best our knowledge, the effect of monotherapy with MO in the treatment of stress‐induced anxiety and depression has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Ghazizadeh

Hamedeyazdan

Torbati

et al. 2020

Experimental Physiology

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This study evaluated the effects of a hydro-alcoholic extract of Melissa officinalis (HAEMO) on anxiety-and depressive-like behaviours, oxidative stress and apoptosis markers in restraint stress-exposed mice. In order to induce a depression-like model, mice were subjected to restraint stress (3 h day −1 for 14 days) and received normal saline or HAEMO (50, 75 and 150 mg kg −1 day −1 ) for 14 days. The administered doses of HAEMO were designated based on the concentration of one of the main phenolic compounds present in the extract, rosmarinic acid (2.55 mg kg −1 at lowest dose); other phytochemical analyses including assays for antioxidant activity, total phenols and flavonoids were also carried out. The behavioural changes in an open field task, elevated plus maze, tail suspension and forced swimming tests were evaluated. Also, malondialdehyde (MDA) levels and enzyme activities of superoxide dismutase and glutathione peroxidase, and total antioxidant capacity were assessed in the prefrontal cortex and hippocampus. Moreover, levels of Bcl-2, Bax and caspase 3 in the brain as well as serum concentration of corticosterone were evaluated. HAEMO (75 and 150 mg kg −1 ) significantly reversed anxiety-and depressive-like behaviours. Also, HAEMO reduced MDA levels, enhanced enzymatic antioxidant activities and restored serum levels of corticosterone. An immunoblotting analysis also demonstrated that HAEMO decreased levels of pro-apoptotic markers and increased anti-apoptotic protein levels in the prefrontal cortex and hippocampus of restraint stress-exposed mice. Our findings suggested that HAEMO reduced inflammation and had anxiolytic and antidepressant effects in mice.

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Section: Discussionmentioning

confidence: 99%

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Ghazizadeh

Hamedeyazdan

Torbati

et al. 2020

Experimental Physiology

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“…Badania prowadzone przez Haybar i wsp. [22] wykazały, że przyjmowanie melisy lekarskiej przez dwa miesiące istotnie zmniejsza problemy ze snem, nerwowością czy depresją u pacjentów z dusznicą bolesną.…”

Section: Wpływ Na Metabolizm Neurotransmiterówunclassified

Health benefits of lemon balm (Melissa officinalis L.)

Połumackanycz¹,

Wesołowski²,

Viapiana³

2020

Farm Pol.

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M elisa lekarska (rycina 1) jest rośliną osiągającą od 30 do 125 cm wysokości, której całą powierzchnię pokrywają miękkie włoski. Liście (rycina 2) są sercowatojajowate, lekko owłosione o długości od 4 do 8 cm i szerokości 3 cm. Mają barwę ciemnozieloną, lecz od spodu są szarozielone, zaś brzegi ich są karbowano-ząbkowane. Kwiaty są białe lub bladoróżowe, a nasiona, o długości od 1 do 1,5 mm, przyjmują ciemnobrązową lub czarną barwę. Surowiec stanowią liście i ulistnione szczyty pędów melisy lekarskiej, zebrane z roślin niekwitnących, szybko wysuszone w cieniu, w temperaturze poniżej 35ºC. Melisa lekarska to roślina rozpowszechniona na kuli ziemskiej, chociaż jej pochodzenie nie jest do końca wyjaśnione. Przypuszcza się, że pochodzi ze wschodniego regionu śródziemnomorskiego, zachodniej Azji, południowej Europy, Kaukazu i północnego Iranu [4]. Melisa lekarska wykorzystywana była w medycynie od najdawniejszych czasów. W średniowieczu była stosowana w zapobieganiu krwawień dziąseł, bólu zębów, ucha oraz zapalenia oskrzeli [5]. Thomas Cogen, angielski lekarz żyjący na przełomie XVI i XVII w., zalecał swym studentom codzienne picie naparu z melisy w celu poprawy pamięci. W duńskiej medycynie ludowej melisa była stosowana przy bezsenności spowodowanej smutkiem i melancholią [6], zaś w austriackiej-w formie naparu lub do użytku zewnętrznego (ze względu na olejki eteryczne)w chorobach układu pokarmowego i nerwowego oraz w problemach z wątrobą i woreczkiem żółciowym [7]. Inhalacje z olejku melisy były zalecane na koszmary senne. Melisa lekarska najczęściej Health benefits of lemon balm (Melissa officinalis L.) • More than 20 000 plant species are used in various traditional medicines around the world, and are considered as potential reservoirs for discovery of new drugs. One of these plants is Melissa officinalis L., commonly known as lemon balm, belongs to the family of Lamiaceae. For more than 2000 years, fragrant leaves of this plant have been widely used in cooking to add flavor to dishes. Moreover, lemon balm has also been used for the treatment of various mental diseases [1], migraines, digestion and cardiovascular problems [2], and sleeping aid [3]. Medicinal properties of Melissa officinalis L. Were first introduced by Dioscorides, the father of pharmacology, in De Materia Medica. Since them, medicinal properties of this plant were mentioned in many other medical books including Canon of Medicine by Avicenna. Melissa officinalis L. is listed in several pharmacopeias including European Pharmacopeia, British Herbal Pharmacopeia and Iranian Herbal Pharmacopeia. Modern studies demonstrated that Melissa officinalis L. has several biological properties including hypoglycemic, antioxidant, hypolipidemic, anticancer, antidepressant, antimicrobial, anxiolytic, anti-inflammatory, antinociceptive and spasmolytic properties. Melissa officinalis L. owes its biological properties to the chemical composition. The main active constituents of lemon balm are volatile compounds, terpenes, phenolic acids and flavonoids, while hydroc...

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“…There are many streams of pathways describing the uses of lemon balm, where the concentration variations of monoamines like serotonin (5-HT) in the CNS. The selective serotonin in the CNS was checked by the antioxidant property [52].…”

Section: Lemon Balmmentioning

confidence: 99%

Medicinal Herbs and Phytochemicals Used in the Treatment of Depression: A Review

Mehdi

et al. 2019

Asian J Pharm Clin Res

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Depression is a condition of no mood and loss of interest in any activity that can diminish a person’s thinking, conduct, tendencies, emotional state, and a sense of well-being. Although there is a conventional class of medication which have been beneficial in the treatment of depression, current studies have reported having side effects which can be minimized by the intervention of herbs and phytochemicals. Most of the studies have proven the various mechanisms and have started to research a very ground-breaking method by glancing the ancient treatmen. Where this new approach of using the herbs and phytochemicals has shown better results alone and in combination with conventional drugs which has shown lesser adverse effects. The practice of phytomedicine is an additional option for the treatment of depression. In the various segments of treating the depression, the mainstream can be a breakthrough including phytoconstituents. In this aspect, there are many contributions for the treatment of the depression acting to the neuronal level signaling and the phytoconstituents also have shown some basic mechanisms in the treatment of depression as that of the conventional medications following some primary hypothesis and signaling pathways and life interactions that effects the brain in either way to treat the depression in all sort of way. Clinical evidence is required to provide backing to the safety and effectiveness of herbs and phytochemicals alone or in combination with currently available drugs to overcome the reported side effects during the treatment of depression.

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The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina

Cited by 68 publications

References 20 publications

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Health benefits of lemon balm (Melissa officinalis L.)

Medicinal Herbs and Phytochemicals Used in the Treatment of Depression: A Review

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