The effects of mercury on muscarinic cholinergic receptor subtypes (M1 and M2) in captive mink

Dietary and tissue selenium in relation to methylmercury toxicity

“…Impaired growth and disruption of motor function are easily observed indications of severe methylmercury toxicity. However, more sensitive biochemical Basu et al, 2008) and functional (Day et al, 2005;Reed et al, 2006Reed et al, , 2008 indicators of neurotoxicity are needed when assessing more subtle consequences of lower methylmercury exposure.…”

Assessing the neurotoxicological risk of methylmercury exposure for beluga whales (delphinapterus leucas) harvested in the Mackenzie Delta Estuary.

“…Overall, these findings were consistent with results from previous avian and wildlife studies (Basu et al, 2005a;Basu et al, 2007b;Basu et al, 2008;Basu et al, 2007c;Basu et al, 2009;Rutkiewicz et al, 2011;Scheuhammer et al, 2008).…”

“…Five beluga whales had Hg concentrations between 1.0 and 4.0 mg kg'1 ww, which is the range in which we would expect to observe biochemical changes but not clinical symptoms (Basu et al, 2007a;Basu et al, 2008;Suzuki, 1979;Wobeser et al, 1976). Overall, the concentrations o f Hg in brain tissue were below levels of clinical symptoms.…”

Biomarkers of the cholinergic and dopaminergic signaling pathways in Arctic beluga whales (Delphinapterus leucas): relationship to methylmercury and selenium

“…significant increase in mAChR binding in the occipital cortex and brain stem of captive mink associated with MeHg exposure but no effect on cerebellum in mink (Basu et al 2006b;Basu et al 2008) or cerebellum, frontal lobes, and occipital lobes in polar bear (Krey et al 2014). The positive relationship between MeHg and mAChR in mink was attributed to a regulatory response to the accumulation of MeHg in the brain (Basu et al 2008).…”

“…The positive relationship between MeHg and mAChR in mink was attributed to a regulatory response to the accumulation of MeHg in the brain (Basu et al 2008). The mAChR may play a critical role in physiological processes including thermoregulation, motor function, and feeding (Bymaster et al 2003;Wess 2004).…”