The effects of methylene blue on adhesion formation in a rat model of experimental peritonitis

Methylene blue 1% solution on the prevention of intraperitoneal adhesion formation in a dog model

“…Nonetheless, other studies revealed that MB solution not only infl uences adhesion formation, but also delays the healing of intestinal anastomosis (DINC et al, 2006) and abdominal wall (KALAYCI et al, 2011). Thus, MB should be further evaluated before its routine use, especially due to such dual effect.…”

Antienflamatuar and antiadhesive effect of clioquinol

“…Adhesion formation is a dynamic and complex process. The perturbation of the equilibrium between fibrin formation and fibrinolysis and enhanced inflammatory responses play active roles [7,8]. Many agents have been employed to prevent adhesion formation.…”

“…Sham operated rats had a laparotomy but no induction of adhesions. After laparotomy, in salinetreated, CMS-H treated, MB treated and CLQ treated groups, 2 mL of saline, 3 m 2 adhesion barrier of CMS-H, 2 mL of 1% MB solution and 20 mg/kg of CLQ were applied to the adhesion site, respectively [8,10]. The abdominal cavity was closed with continuous 3/0 polypropylene sutures.…”

“…Adhesion formation is a complex process involving cellular, biochemical and immunological factors. An enhanced inflammatory response and the perturbed equilibrium between fibrin formation and fibrinolysis are lead to the development of adhesions [7,8]. Although many treatment methods having been described to prevent adhesions, it remains a major clinical problem [4,9].…”

Effects of saline lavage temperature on peritoneal fibrinolysis and adhesion formation

“…On the other hand, saline is used generally as control in the peritoneal adhesion models of intraabdominal medication. When saline lavage or installation is included into the experimental groups, three different results are observed; beneficial, [10][11][12][13][14] ineffective, [9,[15][16][17][18] or even harmful. [19,20] Another challenge in peritoneal adhesion studies is the use of several different models.…”