The effects of methylphenidate on cognitive performance of healthy male rats

Rostron, Claire L.; Kaplan, Elise; Gaeta, Victoria; Nigriello, Rachel; Dommett, Eleanor J.

doi:10.3389/fnins.2013.00097

Cited by 5 publications

(4 citation statements)

References 71 publications

(113 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MPH is one of the well‐known drugs used for treatment of attention deficit hyperactive disorder (ADHD). Students and healthy individuals may also utilize MPH for better learning capacity as a cognitive enhancer (Rostron, Kaplan, Gaeta, Nigriello, & Dommett, 2013). This formula has the potential of recreational use and can become a drug of abuse.…”

Section: Introductionmentioning

confidence: 99%

What are the consequences of Methylphenidate exposure for maternally separated rats?

Borzadaran

Esmaeilpour

Joushi

et al. 2020

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Methylphenidate (MPH) abuse is prevalent among youth. Drug abuse results in pain perception. We sought to investigate whether Maternal separation (MS) prone to MPH addiction. The next question was whether MPH abusers with MS differ in pain perception. We investigated the impact of MS on addiction and drug reward as well as pain perception following 5 days of MPH injection in males and females rats. Initially, rats underwent MS protocol of 3 hr daily for 21 days. Conditioned place preference (CPP) test was an attempt to investigate whether MS rats experience more reward with MPH. The protocol consisted of 10 min habituation on Day 1, conditioning on Day 2-Day 6 (5 mg per kg MPH injection in drug compartment and saline in saline compartment with 4 hr gap between injections) and 10 min test on Day 7. Furthermore, using another group, differences in pain perception were investigated after 5 days of daily MPH injection with 5 mg per kg. Sensory pain sensitivity was tested on PND 39 using tail flick and hotplate in MS and control groups with and without MPH exposure. Results indicated that female rats are equally prone to addiction in CPP. On the other hand, MS males experience a higher reward in CPP. In tail flick test, female MS rats exposed to MPH show a lower sensory pain threshold with similar MPH exposure. Experiencing MPH similarly declined hotplate pain perception in MS and controls in the females. Males, on the other hand, did not show any difference in sensory pain tests. According to results one can argue MS is detrimental. MS males experience more reward with MPH, females are equally addiction prone and MS females experience more pain in tail flick. On the other hand pain threshold can decline in hotplate test for both control and MS females that received MPH.

show abstract

Section: Introductionmentioning

confidence: 99%

What are the consequences of Methylphenidate exposure for maternally separated rats?

Borzadaran

Esmaeilpour

Joushi

et al. 2020

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…A recent study [18] also reports this kind of "bellshaped" dose-response curve for acquisition in the Morris water maze and for activity in the open field, although at somewhat lower doses. On the other hand, Rostron and colleagues report that MPH, at 3 and 5 mg/kg given orally, has no or detrimental effects on performance in rats in more sophisticated tests (Random Foraging Non-Delay Task and Delayed Spatial Win Shift Task; [19]). Thus, in rodent models, MPH, like modafinil [16] seems to improve learning only for simple tasks, while lowering performance for more complicated ones.…”

mentioning

confidence: 98%

Methylphenidate has long-lasting metaplastic effects in the prefrontal cortex of adolescent rats

Burgos

Cofré²,

Hernández³

et al. 2015

Behavioural Brain Research

View full text Add to dashboard Cite

“…Furthermore, as this drug decreased rather than increased response latency, an impaired visual discrimination seems unlikely. Hence, reduced PAL performance under methylphenidate (9 mg/kg) may not reflect impaired visual discrimination or sustained attention.Of note, there is evidence that methylphenidate facilitates memory for aversive events (Bethancourt et al 2009) and can improve spatial learning and memory retrieval in a radial maze task (Zhu et al 2007, but see Rostron et al 2013). Interestingly, methylphenidate was also able to compromise object recognition memory (Heyser et al 2004).…”

mentioning

confidence: 99%

“…Of note, there is evidence that methylphenidate facilitates memory for aversive events (Bethancourt et al 2009) and can improve spatial learning and memory retrieval in a radial maze task (Zhu et al 2007, but see Rostron et al 2013). Interestingly, methylphenidate was also able to compromise object recognition memory (Heyser et al 2004).…”

mentioning

confidence: 99%

Stimulant drug effects on touchscreen automated paired-associates learning (PAL) in rats

2016

View full text Add to dashboard Cite

Here we tested in rats effects of the procognitive drugs modafinil and methylphenidate on post-acquisition performance in an object -location paired-associates learning (PAL) task. Modafinil (32; 64 mg/kg) was without effect, while higher (9 mg/ kg) but not lower (4.5 mg/kg) doses of methylphenidate impaired PAL performance. Likewise, higher but not lower doses of amphetamine (0.4; 0.8 mg/kg) and MK-801 (0.08; 0.12 mg/kg) decreased PAL performance. Impaired PAL performance induced by methylphenidate, amphetamine, and MK801 most likely reflects compromised cognitive function, e.g., retrieval of learned paired associates. Our data suggest that stimulant drugs such as methylphenidate and modafinil might not facilitate performance in hippocampus-related cognitive tasks.[Supplemental material is available for this article.]Touchscreen equipped operant boxes represent a powerful tool to study cognition in rats. This methodology provides superior translational potential because a number of different cognitive tasks can be run that mirror touchscreen methods being part of the Cambridge Neuropsychological Test Automated Battery (CANTAB) used to test human subjects. For instance, the pairedassociates learning task (PAL) allows to investigate learning of object-location associations in rodents and humans Mar et al. 2013;Talpos and Steckler 2013;Josey and Brigman 2015). In rats, post-acquisition performance on the PAL task is sensitive to hippocampal dysfunction. For instance, intrahippocampal microinfusions of lidocaine or NMDA and AMPA receptor antagonists impaired PAL performance in animals that acquired the task before (Talpos et al. 2009). Likewise, in mice, post-acquisition intrahippocampal microinfusions of muscimol impaired PAL performance (Kim et al. 2015). In humans, PAL task performance is predictive of the conversion from mild cognitive dysfunction to Alzheimer's disease (Blackwell et al. 2004). Furthermore, in mild cognitive impairment, PAL performance was correlated with hippocampal volume (Keri et al. 2012).To date, little is known about effects of procognitive drugs on PAL performance. The few available data show that, in mice, the cholinesterase inhibitor donezepil (0.3 mg/kg, i.p.) facilitated PAL performance (Bartko et al. 2011). In contrast, the effects of two other prominent procognitive drugs, methylphenidate and modafinil, in PAL have not been tested yet. Modafinil facilitated performance in a number of rodent cognitive tasks (Beracochea et al. 2001(Beracochea et al. , 2002(Beracochea et al. , 2003Shuman et al. 2009), e.g., enhanced visual discrimination and visual sustained attention (Morgan et al. 2007). Likewise, methylphenidate improved acquisition and retention of spatial memory in maze tasks (Carmack et al. 2014). Both drugs seem to be used as cognitive enhancers for nonmedical purposes (McCabe et al. 2005). However, for both drugs, evidence in favor of cognitive enhancement in humans is mixed (Repantis et al. 2010). For instance, in healthy individuals, methylphenidate and modafinil did not imp...

show abstract

The effects of methylphenidate on cognitive performance of healthy male rats

Cited by 5 publications

References 71 publications

What are the consequences of Methylphenidate exposure for maternally separated rats?

What are the consequences of Methylphenidate exposure for maternally separated rats?

Methylphenidate has long-lasting metaplastic effects in the prefrontal cortex of adolescent rats

Stimulant drug effects on touchscreen automated paired-associates learning (PAL) in rats

Contact Info

Product

Resources

About