1957
DOI: 10.1002/jez.1401360207
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The effects of microquantities of beryllium ion on the regenerating forelimb of the adult newt, Triturus

Abstract: EIGHT FIGURESThe beryllium ion has been shown by Needham ('41) and Thornton ('49, '50, '51) to be harmful to regeneration of the extremities and the tail of amphibian larvae. Following brief immersion in N/7 beryllium nitrate, the tail of the tadpole failed to regrow (Needham). After similar treatment, the amputated limb of the larval salamander not only failed to regenerate but the stump was partly resorbed (Thornton). We have studied the influence of beryllium on forelimb regeneration in the adult newt after… Show more

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Cited by 19 publications
(8 citation statements)
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“…Because we did not observe complete inhibition of limb regeneration, our results probably reflect differences in size and stage (larvae versus juvenile) of animals across studies where larval limbs contain far fewer connective tissue fibroblasts. Previous studies showing that beryllium completely inhibits regeneration in other Ambystoma species, newts and Xenopus larvae (Thornton, 1949(Thornton, , 1950(Thornton, , 1951Scheuing and Singer, 1957;Tsonis et al, 1991;Mescher et al, 2013), have also documented that the BeN effect is size dependent (for a given concentration), with reduced effects observed on larger organisms (Thornton, 1949). Axolotls used in the present experiments were larger (7-9 cm) compared with larval salamanders and tadpoles used in all previous experiments, suggesting that a similar concentration of BeN may be insufficient to achieve complete inhibition.…”
Section: Discussionsupporting
confidence: 63%
“…Because we did not observe complete inhibition of limb regeneration, our results probably reflect differences in size and stage (larvae versus juvenile) of animals across studies where larval limbs contain far fewer connective tissue fibroblasts. Previous studies showing that beryllium completely inhibits regeneration in other Ambystoma species, newts and Xenopus larvae (Thornton, 1949(Thornton, , 1950(Thornton, , 1951Scheuing and Singer, 1957;Tsonis et al, 1991;Mescher et al, 2013), have also documented that the BeN effect is size dependent (for a given concentration), with reduced effects observed on larger organisms (Thornton, 1949). Axolotls used in the present experiments were larger (7-9 cm) compared with larval salamanders and tadpoles used in all previous experiments, suggesting that a similar concentration of BeN may be insufficient to achieve complete inhibition.…”
Section: Discussionsupporting
confidence: 63%
“…Leukocyte infiltration of the regenerating limbs was not stimulated by Be which, however, was found to inhibit migration and proliferation of both dermal fibroblasts and blastema cells, with no increase in apoptosis and without affecting either migration or growth of epidermal cells (Cook & Seifert, ). The results were interpreted to suggest that in urodeles Be disrupts regenerative patterning of limbs by directly interfering with mesenchymal cell or fibroblast migration and growth, a conclusion consistent with the effects of Be infused into regenerating limbs of adult newts (Scheuing & Singer, ).…”
Section: Studies Of the Inflammatory Response In Amphibian Appendage supporting
confidence: 55%
“…The results were interpreted to suggest that in urodeles Be disrupts regenerative patterning of limbs by directly interfering with mesenchymal cell or fibroblast migration and growth, a conclusion consistent with the effects of Be infused into regenerating limbs of adult newts (Scheuing & Singer, 1957).…”
Section: Similar Leukocyte Immigration and Cytokine Inductions Were Fmentioning
confidence: 63%
“…Thornton [39] , [51] and Singer [52] also used regenerating limbs of larval Ambystoma and adult newts respectively to test for toxicity after infusing millimolar solutions of Be compounds into blastemas. In those studies blastema growth and regeneration continued, but with increased inflammation, fibrosis and severe patterning defects, results consistent with the data reported here.…”
Section: Resultsmentioning
confidence: 99%