The Effects of Mitral Valvuloplasty on Cardiovascular and Renal Function at Rest and During Exercise 1

The Relationship of Cardiovascular and Renal Hemodynamic Function to Sodium Excretion in Patients With Severe Heart Disease but Without Edema 12

“…Simultaneous cardiovascular and renal hemodynamic measurements were made at rest and during exercise by methods identical to those previ- 1 Presented at the annual meeting of the American Heart Association, Chicago, Illinois, April 4, 1954. 2This investigation was supported in part by a grant from the National Heart Institute of the National Institutes of Health, U.S.P.H.S. a Present address: Department of Medicine, Indiana University Medical Center, Indianapolis, Ind. ously described (3). Exercise was performed in the supine position by alternate straight leg-raising for six to nine minutes.…”

The Diffusing Capacity of the Lungs in Patients With Mitral Stenosis Studied Post-Operatively 1

“…Because of their location in relation to vascular structures, one would expect that such lesions might interfere with the flow of blood through the lungs or with the diffusion of gases across the pulmonary membrane. Hemodynamic studies by a number of different workers have demonstrated an increase in pulmonary vascular resistance in patients with mitral stenosis (4)(5)(6)(7)(8)(9)(10). This paper deals with studies of the diffusion of gases across the pulmonary membrane in a group of patients on whom mitral valvulotomy had been performed.…”

The Effects of Exercise on Cardiovascular and Renal Function in Cardiac Patients With and Without Heart Failure 1

“…Individual cardiovascular and renal data at rest and in response to exercise are presented in Tables I and II; detailed data on seven other patients (A. L., C. S., E. M., C. M., E. T., A. C., J. C.) with predominately mitral stenosis have already been published (8). The means for all (including these seven) patients together with a statistical analysis are shown in Table III Arterial pressure.…”

“…8 Formerly Fellow in Medicine, Evans Memorial, Massachusetts Memorial Hospitals; Present Address: Queen's University, Kingston, Ontario, Canada. this group were considered to have some degree of circulatory failure as indicated by an impaired cardiac output response during exercise, by an abnormal right ventricular end diastolic pressure of over 8 mm. Hg, or both.…”

“…The patients were studied in the post-absorptive state without sedative medication. The experimental procedure and methods of measurement of cardiovascular and renal functions were similar to those previously described (8).…”