The effects of model androgen 5α-dihydrotestosterone on mummichog (Fundulus heteroclitus) reproduction under different salinities

Glinka, Chelsea O.; Frasca, Salvatore; Provatas, Anthony A.; Lama, Tanya; DeGuise, Sylvain; Bosker, Thijs

doi:10.1016/j.aquatox.2015.05.019

Cited by 13 publications

(7 citation statements)

References 54 publications

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“…The result of this study is contrary to Glinka et al [38], who reported that 5α dihydrotestosterone (an EDC) did not affect egg production of an estuarine fish, Mummichog (Fundulus heteroclitus) at low salinity (1.0-2.5‰). Homoeostasis to balance osmotic regulation and reproduction and other physiological activities might have been disrupted [37,38].…”

Section: Discussioncontrasting

confidence: 99%

“…Fecundity is one of the factors that predict the functions of the gonads and mating behaviour in fish [36]. There was a decreased in reproduction of three euryhaline species, i.e., western mosquitofish (Gambusia affinis), sailfin molly (Poecillia latipinna), and least killifish (Heterandria formosa), in low salinity [37,38]. The result of this study is contrary to Glinka et al [38], who reported that 5α dihydrotestosterone (an EDC) did not affect egg production of an estuarine fish, Mummichog (Fundulus heteroclitus) at low salinity (1.0-2.5‰).…”

Section: Discussionmentioning

confidence: 99%

“…There was a decreased in reproduction of three euryhaline species, i.e., western mosquitofish (Gambusia affinis), sailfin molly (Poecillia latipinna), and least killifish (Heterandria formosa), in low salinity [37,38]. The result of this study is contrary to Glinka et al [38], who reported that 5α dihydrotestosterone (an EDC) did not affect egg production of an estuarine fish, Mummichog (Fundulus heteroclitus) at low salinity (1.0-2.5‰). Homoeostasis to balance osmotic regulation and reproduction and other physiological activities might have been disrupted [37,38].…”

Section: Discussionmentioning

confidence: 99%

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Reproductive Toxicity of 3,4-dichloroaniline (3,4-DCA) on Javanese Medaka (Oryziasjavanicus, Bleeker 1854)

Ibrahim

Zulkifli

Azmai

et al. 2021

Animals

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Compound 3,4-dichloroaniline (3,4-DCA) is a metabolite of several urea herbicides and intermediate chemical of several industrial products. Moreover, 3,4-DCA has been frequently detected in aquatic ecosystems around the world. This aniline is more toxic than the parent chemicals, and it affects non-target organisms. This study evaluated a 21-day reproductive response of an emerging aquatic vertebrate model, Javanese medaka (Oryzias javanicus), exposed to 3,4-DCA. Fecundity and gonads histopathology were observed. The spawning rate and fertilisation reduced significantly in the highest exposed-group (250 µg/L). Gonadosomatic index (GSI) was significantly low in females exposed to 250 µg/L. No substantial structural alteration of male gonads. However, oocyte development and ovarian cell structure were disrupted in 250 µg/L exposed females. The gonadal developmental was not affected in the males; however, a significant reduction in the developmental of female gonads was observed at 250 µg/L. These results show that 3,4-DCA interfere with the reproduction of Javanese medaka through fecundity and alteration of gonadal tissues.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Reproductive Toxicity of 3,4-dichloroaniline (3,4-DCA) on Javanese Medaka (Oryziasjavanicus, Bleeker 1854)

Ibrahim

Zulkifli

Azmai

et al. 2021

Animals

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“…In the current study, exposure of female zebrafish to 11-KT did not affect gnrh3 mRNA expression. In female mummichogs, exposure to 5α-dihydrotestosterone for 21 days was shown to affect fecundity, particularly low egg production 34 . Trenbolone acetate, a synthetic androgen, was also shown to decrease ovarian follicles in female Japanese medaka after 14 days of exposure 35 .…”

Section: Discussionmentioning

confidence: 99%

Bpifcl modulates kiss2 expression under the influence of 11-ketotestosterone in female zebrafish

Moriya

Tahsin

Parhar

2017

Sci Rep

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The bactericidal/permeability-increasing (BPI) fold-containing (BPIF) superfamily of genes expressed in the brain are purportedly involved in modulating brain function in response to stress, such as inflammation. Kisspeptin, encoded by kiss, is affected by inflammation in the brain; therefore, BPIF family genes might be involved in the modulation of kisspeptin in the brain. In this study, we investigated the expression of BPIF family C, like (bpifcl) in zebrafish brain and its involvement in kiss2 regulation. The identified, full-length sequence of a bpifcl isoform expressed in the zebrafish brain contained the BPI fold shared by BPIF family members. bpifcl mRNA expression in female zebrafish brains was significantly higher than that in males. Exposure of female zebrafish to 11-ketotestosterone decreased bpifcl and kiss2 mRNA expression. bpifcl knockdown by bpifcl-specific small interfering RNA administration to female zebrafish brain decreased kiss2 mRNA expression. bpifcl expression was widely distributed in the brain, including in the dorsal zone of the periventricular hypothalamus (Hd). Furthermore, bpifcl was also expressed in KISS2 neurons in the Hd. These results suggest that the Bpifcl modulates kiss2 mRNA expression under the influence of testosterone in the Hd of female zebrafish.The bactericidal/permeability-increasing (BPI) fold-containing (BPIF) superfamily of genes is functionally classified into five groups: palate, lung and nasal epithelium clone (PLUNC); lipopolysaccharide-binding protein (LBP); BPI protein; phospholipid transfer protein (PLTP); cholesterol ester transfer protein (CETP) 1, 2 . All BPIF family members share the BPI fold, which has an elongated, boomerang shape consisting of two distinct N-and C-terminal domain barrels with a highly similar secondary structure 3 . Both domains consist of two twisted, anti-parallel β-sheets and two α-helices, with both domains connected to each other by a β-sheet 4 .BPIF family of genes are expressed in a wide range of vertebrates 5 and mainly involved in the innate immune system and lipoprotein metabolism. BPI and LBP are plasma proteins that play an important role in the innate immune system against invading pathogens owing to a high affinity for the lipopolysaccharides of Gram-negative bacteria 3,6 . PLUNC proteins are suggested to be host defence molecules because their expression alters in response to inflammation caused by smoking, chemical irritants, and infection 7,8 . CETP and PLTP are both plasma proteins that play an important role in lipoprotein metabolism 9,10 . Recently, the expression of BPIF family of genes has been reported in the brain 11 . We have also reported the expression of BPIF family of genes, such as bpifa1, gm1006 and rya3 in the mouse brain, particularly in the preoptic area 12 . The expression of these genes decreases with age. Because ageing causes oxidative stress and inflammation in the brain 13 , the identified BPIF family of genes might respond to oxidative stress and inflammation similar to the PLUNC protein grou...

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“…However, among four exposure durations assessed (1, 2, 4, 8 d), E2 production was only reduced following 2 d of exposure.  Glinka et al (2015) reported reductions in E2 production in female Fundulus heteroclitus following 21 d of exposure to 0.5 or 5.0 ug 5alpha-dihydrotestosterone.  Rutherford et al (2015) demonstrate reduced E2 production in Fundulus heteroclitus following exposure to 100 ug 5alpha-dihydrotestosterone (a nonaromatizable androgen) or 0.1 and 1.0 ug methyltestosterone (an aromatizable androgen) for 14 d,  reported reductions in E2 production in female Fundulus heteroclitus following exposure to 0.25 or 1.0 ug methyltestosterone/L for 7d, and in females exposed to 0.001, 0.01, or 0.1 ug methyltestosterone/L for 14 d.…”

Section: Empirical Evidencementioning

confidence: 99%

Adverse Outcome Pathway on Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)

Villeneuve¹

2018

OECD Series on Adverse Outcome Pathways

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This Adverse Outcome Pathway (AOP) on Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish), has been developed under the auspices of the OECD AOP Development Programme, overseen by the Extended Advisory Group on Molecular Screening and Toxicogenomics (EAGMST), which is an advisory group under the Working Group of the National Coordinators for the Test Guidelines Programme (WNT). The AOP has been reviewed internally by the EAGMST, externally by experts nominated by the WNT, and has been endorsed by the WNT and the Working Party on Hazard Assessment (WPHA) in June 2018. Through endorsement of this AOP, the WNT and the WPHA express confidence in the scientific review process that the AOP has undergone and accept the recommendation of the EAGMST that the AOP be disseminated publicly. Endorsement does not necessarily indicate that the AOP is now considered a tool for direct regulatory application. The Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology agreed to declassification of this AOP in September 2018. This document is being published under the responsibility of the Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. The outcome of the internal and external reviews are publicly available respectively in the AOP Wiki and the eAOP Portal of the AOP Knowledge Base at the following links: [internal review] [external review].

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The effects of model androgen 5α-dihydrotestosterone on mummichog (Fundulus heteroclitus) reproduction under different salinities

Cited by 13 publications

References 54 publications

Reproductive Toxicity of 3,4-dichloroaniline (3,4-DCA) on Javanese Medaka (Oryziasjavanicus, Bleeker 1854)

Reproductive Toxicity of 3,4-dichloroaniline (3,4-DCA) on Javanese Medaka (Oryziasjavanicus, Bleeker 1854)

Bpifcl modulates kiss2 expression under the influence of 11-ketotestosterone in female zebrafish

Adverse Outcome Pathway on Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)

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