The effects of Momordica charantia (bitter melon) supplementation in patients with primary knee osteoarthritis: A single-blinded, randomized controlled trial

May, Lim Soo; Sanip, Zulkefli; Shokri, Amran Ahmed; Kadir, Azidah Abdul; Lazin, Rizman Md Lazim Md

doi:10.1016/j.ctcp.2018.06.012

Cited by 25 publications

(10 citation statements)

References 26 publications

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“…After 3 months, there were significant improvements in knee osteoarthritis and reduction in analgesic score; also, body weight, body mass index, and fasting blood glucose were significantly reduced. In this study, it was demonstrated that MC can represent an alternative to reducing pain and improving symptoms among patients while reducing the need for analgesic drug consumption (Soo May et al, 2018).…”

Section: Anti-inflammatory and Anti-oxidant Activity Of Momordica Chamentioning

confidence: 99%

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

2019

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Momordica charantia , commonly called bitter melon, is a plant belonging to Cucurbitaceae family known for centuries for its pharmacological activities, and nutritional properties. Due to the presence of many bioactive compounds, some of which possess potent biological actions, this plant is used in folk medicine all over the world for the treatment of different pathologies, mainly diabetes, but also cancer, and other inflammation-associated diseases. It is widely demonstrated that M. charantia extracts contribute in lowering glycaemia in patients affected by type 2 diabetes. However, the majority of existing studies on M. charantia bioactive compounds were performed only on cell lines and in animal models. Therefore, because the real impact of bitter melon on human health has not been thoroughly demonstrated, systematic clinical studies are needed to establish its efficacy and safety in patients. Besides, both in vitro and in vivo studies have demonstrated that bitter melon may also elicit toxic or adverse effects under different conditions. The aim of this review is to provide an overview of anti-inflammatory and anti-neoplastic properties of bitter melon, discussing its pharmacological activity as well as the potential adverse effects. Even if a lot of literature is available about bitter melon as antidiabetic drug, few papers discuss the anti-inflammatory and anti-cancer properties of this plant.

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Section: Anti-inflammatory and Anti-oxidant Activity Of Momordica Chamentioning

confidence: 99%

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

2019

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“…Overall, out of 25 dietary supplements identified, 17 of them demonstrated beneficial effect on clinical signs and symptoms. These dietary supplements were krill oil (Suzuki et al, 2016), avocado/soybean unsaponifiables (ASU) (Appelboom et al, 2001), curcumin (Gianni Belcaro et al, 2010;Nakagawa et al, 2014;Panahi et al, 2014;Srivastava et al, 2016), BSE (Sengupta et al, 2008;Sengupta et al, 2010;Vishal et al, 2011), Pycnogenol (Belcaro et al, 2008a;Cisár et al, 2008;Farid et al, 2007), purple fruit passion peel (PFP) extract (Farid et al, 2010), L-carnitine (Malek Mahdavi et al, 2015;Malek Mahdavi, Mahdavi and Kolahi, 2016), Artemisia annua (ART) extract (Hunt et al, 2016), deer bone extract (DBE) (Shin et al, 2018), garlic (Dehghani et al, 2018;Salimzadeh et al, 2018), Momordica charantia (Lim et al, 2018), argan oil (Essouiri et al, 2017) pomegranate juice (PJ) (Ghoochani et al, 2016), sesame seed (Eftekhar Sadat et al, 2013), Phytalgic® (Jacquet et al, 2009), soy protein (Arjmandi et al, 2004) and calcium fructoborate (CFB) (Pietrzkowski et al, 2014). Frestedt et al (2009) reported that Aquamin supplementation is ineffective in symptoms of improvement among OA patients.…”

Section: Dietary Supplements With Positive Resultsmentioning

confidence: 99%

“…The remaining 23 studies were conducted in Asian countries. All of the studies included were single-center double-blind RCTs, excluding one study of single-center single-blind RCT (Lim et al, 2018), one study of multicenter double-blind RCT (Altman and Marcussen, 2001), two studies of single-center double-blind prospective study (Debbi et al, 2011;Nakagawa et al, 2014), and two multicenter double-blind prospective studies (Appelboom et al, 2001).…”

Section: Study Characteristicsmentioning

confidence: 99%

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Ong¹,

Sakinah²,

Shahril³

et al. 2019

Food Res.

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The increasing number of evidence has reported inflammation and oxidative stress as key mediators of osteoarthritis (OA) joint pathology. Therefore, the usage of dietary supplements targeting inflammation and oxidative stress in OA may emerge as a rewarding therapeutic strategy. This study aimed to explore the efficacy of antioxidant and anti-inflammatory dietary supplements used to manage OA. A methodological framework proposed by Arksey and O’Malley was used to conduct this scoping review. An electronic database search of English academic articles was conducted using PubMed, MEDLINE and ScienceDirect from 2000 to 2018. Randomized controlled trials (RCTs) of OA with parallel groups by comparing dietary supplements with placebo consumption were eligible for inclusion. Out of 69,150 studies identified, a total of 41 studies were included, with 25 antioxidant or anti-inflammatory dietary supplements identified. There were 3325 respondents (1740 in the treatment group and 1585 in the placebo group), all aged ≥ 25 years old and comprised of 69.6% and 30.4% female and male respondents, respectively. The majority of the studies recruited participants with knee OA (n = 33) with a follow-up duration of 3 to 32 weeks. Overall, most of the dietary supplements (n =17) demonstrated a beneficial effect on the clinical signs and symptoms, such as Boswellia serrata extract (BSE), Pycnogenol and L-carnitine. In contrast, Aquamin supplementation did not exert positive impacts on OA management, while inconsistent findings were observed in greenlipped mussel (GLM) extract, vitamin E, methylsulfonylmethane (MSM), licorice flavonoid oil (LFO), ginger, willow bark extract and rose hip supplementation. In summary, the role of anti-inflammatory and antioxidant dietary supplements cannot be ignored as they can offer alleviated pain and symptom relief.

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“…PubMed and web of science searches using the key word “ Momordica charantia” resulted in 1253 articles for the last 10 years only (2009–2018). Quite recently, several clinical trials have been conducted to examine the efficacy of M. charantia in diabetic patients, and M. charantia supplementation was shown to be quite successful in lowering elevated fasting plasma glucose level in prediabetes patients [4–7]. The exact mechanisms of the antidiabetic and anti-obesity effects of M. charantia are unknown; however, some of the active components isolated from M. charantia are thought to be structurally similar to human insulin [8].…”

Section: Introductionmentioning

confidence: 99%

“…The exact mechanisms of the antidiabetic and anti-obesity effects of M. charantia are unknown; however, some of the active components isolated from M. charantia are thought to be structurally similar to human insulin [8]. Besides being a potent anti-diabetic supplementation, various parts of M. charantia have also been used as a medicine to cure various conditions, such as infection [9–13], wounds [14–16], and osteoarthritis [4, 17]. The plant are also used as laxative, contraceptive, abortifacient, and anthelmintic agents, and also to treat various conditions, such as scabies, jaundice, pneumonia, dysmenorrhea, eczema, gout, leprosy, piles, psoriasis, and rheumatism [18–21].…”

Section: Introductionmentioning

confidence: 99%

Bitter gourd (Momordica charantia) possess developmental toxicity as revealed by screening the seeds and fruit extracts in zebrafish embryos

Farooq

Abutaha

Nasr

et al. 2019

BMC Complement Altern Med

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Background Bitter gourd ( Momordica charantia ) has attracted the focus of researchers owing to its excellent anti-diabetic action. The beneficial effect of Momordica charantia on heart has been reported by in vitro and in vivo studies. However the developmental toxicity or potential risk of M. charantia on fetus heart development is largely unknown. Hence this study was designed to find out the developmental toxicity of M. charantia using zebrafish ( Danio rerio ) embryos. Methods The crude extracts were prepared from fruit and seeds of M. charantia. The Zebrafish embryos were exposed to serial dilution of each of the crude extract. The biologically active fractions were fractionated by C18 column using high pressure liquid chromatography. Fourier-transform infrared spectroscopy and gas chromatography coupled with mass spectrophotometry was done to identify chemical constituents in fruit and seed extract of M. charantia . Results The seed extract of M. charantia was lethal with LD 50 values of 50 μg/ml to zebrafish embryos and multiple anomalies were observed in zebrafish embryos at sub-lethal concentration. However, the fruit extract was much safe and exposing the zebrafish embryos even to 200 μg/ml did not result any lethality. The fruit extract induced severe cardiac hypertrophy in treated embryos. The time window treatment showed that M. charantia perturbed the cardiac myoblast specification process in treated zebrafish embryos. The Fourier-transform infrared spectroscopy analyses revealed diverse chemical group in the active fruit fraction and five new type of compounds were identified in the crude seeds extract of M. charantia by gas chromatography and mass spectrophotometry. Conclusion The teratogenicity of seeds extract and cardiac toxicity by the fruit extract of M. charantia warned that the supplementation made from the fruit and seeds of M. charantia should be used with much care in pregnant diabetic patients to avoid possible damage to developing fetus. Electronic supplementary material The online version of this article (10.1186/s12906-019-2599-0) contains supplementary material, which is available to authorized users.

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The effects of Momordica charantia (bitter melon) supplementation in patients with primary knee osteoarthritis: A single-blinded, randomized controlled trial

Cited by 25 publications

References 26 publications

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Bitter gourd (Momordica charantia) possess developmental toxicity as revealed by screening the seeds and fruit extracts in zebrafish embryos

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