The effects of Morinda citrifolia L. (noni) on the immune system: Its molecular mechanisms of action

Palu, Afa K.; Kim, Anne Hirazumi; West, Brett J.; Deng, Shixin; Jensen, Jarakae; White, Leland

doi:10.1016/j.jep.2007.10.023

Cited by 114 publications

(91 citation statements)

References 26 publications

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“…Noni discovered as a medicinal plant by the ancestors of Polynesians 2000 years ago has been and is still used in traditional medicine, thus being a popular research object. Although first studies on this plant date back to the beginning of 1990s, with two publications in the years of 1907 and 1918 (Simonsen 1920), numerous in vitro and in vivo investigations and clinical trials have started with the advent of noni juice as a health and wellness drink in 1996 and its approval as a novel food by the European Commission in 2003 (Palu et al 2008, Basar et al 2010, Glang et al 2013. Diverse bioactive and therapeutic properties of noni have recently been reviewed by Assi et al (2015), Krishnakumar et al (2015), Motshakeri and Ghazali (2015), Nerurkar et al (2015), and Raja and Sreenivasulu (2015) comprehensively.…”

Section: Discussionmentioning

confidence: 99%

“…Along with its consumption as food and a dye for traditional clothes (Palu et al 2008(Palu et al , 2010, the fruit, leaf, root, seed, bark, stem and flower of this plant have been topically and internally used solely or combined in traditional medicine for over 2000 years in Polynesia to cure and prevent a broad range of human diseases which can be found in reviews by Wang et al (2002), Mathivanan et al (2005), Chan-Blanco et al (2006), Pawlus and Kinghorn (2007), Singh (2012), Gupta and Patel (2013), Saminathan et al (2013), Assi et al (2015), Krishnakumar et al (2015), Motshakeri and Ghazali (2015), Nerurkar et al (2015), and Raja and Sreenivasulu (2015).…”

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confidence: 99%

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Antioxidant and Anti-inflammatory Activities of a Commercial Noni Juice revealed by Carrageenan-induced Paw Edema

Yilmazer¹,

Coşkun²,

Gürel-Gürevin³

et al. 2016

Polish Journal of Veterinary Sciences

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This study aimed to investigate antioxidant and anti-inflammatory activities of a commercial product of noni (Morinda citrifolia) juice. Carrageenan-induced rat paw edema was employed as inflammatory model. One control and three experimental groups were formed. Experimental groups were administered noni juice alone, noni juice+carrageenan, and carrageenan alone. Oxidant and antioxidant capacity were determined by d-ROMs test and BAP test, respectively. Plasma concentrations of endothelin-1 and leptin were measured by ELISA. Measurements were performed at zero time and 2nd hour of inflammation. Oxidant capacity decreased in noni-received groups at 2nd hour (p=0.019). Antioxidant capacity of the group which received noni alone was found to be higher at 2nd hour (p=0.036). Plasma concentrations of endothelin-1 and leptin were notably lower in noni-received groups (p=0.001 and p=0.021, respectively). The results show that the commercial noni juice investigated has pronounced antioxidant and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Antioxidant and Anti-inflammatory Activities of a Commercial Noni Juice revealed by Carrageenan-induced Paw Edema

Yilmazer¹,

Coşkun²,

Gürel-Gürevin³

et al. 2016

Polish Journal of Veterinary Sciences

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“…These results suggested that Noni juice modulates the immune system via activating of the CB 2 receptors and suppressing of the IL-4 but increasing the production of IFN-γ cytokines. 78 Nephroprotective activity Fruit juice can modify renal function and catecholamine contents in doxorubicin induced nephrosis, it was reported that Noni juice reduced plasma cholesterol; doxorubicin induced impaired renal function in rats along with compensatory increase in renal dopamine content. But no beneficial effects on renal function were observed when fruit juice was administered with doxorubicin.…”

Section: Immunomodulatory Effectmentioning

confidence: 99%

Health Benefits of Morinda citrifolia (Noni): A Review

Ali¹,

Kenganora²,

Manjula³

2016

Phcogj

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Background: Morinda citrifolia (Noni) has been used widely as a comple mentary and alternative therapy in many countries owing to its potent anti oxidant activity and proven health benefits. Traditionally, it finds used as a therapeutic remedy to various diseases as an antibacterial, antitumor, anthelminthic, analgesic, anti inflammatory, immunostimulant. Also it has proved beneficial in conditions like gastritis, skin diseases, respiratory infections, menstrual and urinary tract disorders, fever, diabetes and venereal diseases. Objective: This review emphasizes on the phytochemical and mineral profile of the different parts of Noni plant. In addition, this review corroborates the pharmacological basis for the various health benefits, traditional and medicinal applications of Noni. Materials and Methods: All the available information of Noni were collected from electronic databases such as Academic Journals, Ethnobotany, Ethnopharmacology, Springer, PubMed, Google Scholar, Science Direct and other primary and secondary sources. Results: According to our search results pertaining to scientific literature, Morinda citrifolia is used for more than 40 types of ailments worldwide. Crude extract of various parts of plant and fruit juice are reported

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“…Noni (Morinda citrifolia L. family Rubiaceae) is one of the traditional folk medicinal plant [22]. The plant has been shown to have potent antioxidant activity both in vitro and in vivo studies [23].…”

Section: Introductionmentioning

confidence: 99%

Chemoprotective Effect of Noni (Morinda Citrifolia L.) Fruit Juice Against Cisplatin-Induced Nephrotoxicity

Ali

Mruthunjaya

Nandini

et al. 2016

Int J Pharm Pharm Sci

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Objective: Cisplatin (CIS) consumption has become a common problem that affects the health of patients around the globe. Kidney has been suspected to be particularly susceptible to the destructive effects of CIS and nephrotoxic effects are still contentious which in turn affects the Quality of Life (QoL) of patients and increase the mortality rate. This study was conducted to investigate the nephroprotective effect of Noni Juice (NJ) and Divine Noni Gold (DNG) as herbal medicine with established antioxidant properties against the controversial nephrotoxic effect of CIS in mice. Methods:Mice were divided into four groups, each group contained six mice. Group I was kept as normal, Group II received CIS (5.0 mg/kg b. wt. i. p.) on day one for 14 d. Group III and IV received NJ (0.35 ml/mouse p. o.) and DNG (0.35 ml/mouse p. o.) respectively once daily for 14 d, Group V received CIS (5.0 mg/kg b. wt. i. p.) on day one and NJ (0.35 ml/mouse p. o.) once daily for 14 d. Similarly, Group VI received CIS (5.0 mg/kg b. wt. i. p.) on day one and DNG (0.35 ml/mouse p. o.) once daily for 14 d. On day 15 blood from all the mice was collected from the carotid vein and cardiac puncture routes, and the biochemical markers viz. lactate dehydrogenase (LDH), creatinine phosphokinase (CPK), and urea were assessed. Kidney from all the animals was isolated, and catalase (CAT), glutathione (GSH), superoxide dismutase (SOD), thiols and lipid peroxidase (LPO) were estimated.Results: CIS-induced marked kidney injury; congestion of tubules, glomerular distortion foci, thickened and blocked blood vessels. Also showed significant elevation of LDH, CPK, and urea with significant inhibition of CAT, GSH, SOD, thiols activities and simultaneously elevation of LPO level. Co-administration of NJ and DNG respectively with CIS protected kidney tissues via oxidative stress inhibition.Conclusion: NJ and DNG possess protective effect against CIS-induced cellular damage in the kidney by decreasing the level of serum biochemical markers, enhancing the level of enzymatic and non-enzymatic antioxidants and maintaining the LPO level. Results suggest that NJ and DNG have strong nephroprotective effect against CIS-induced nephrotoxicity.

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The effects of Morinda citrifolia L. (noni) on the immune system: Its molecular mechanisms of action

Cited by 114 publications

References 26 publications

Antioxidant and Anti-inflammatory Activities of a Commercial Noni Juice revealed by Carrageenan-induced Paw Edema

Antioxidant and Anti-inflammatory Activities of a Commercial Noni Juice revealed by Carrageenan-induced Paw Edema

Health Benefits of Morinda citrifolia (Noni): A Review

Chemoprotective Effect of Noni (Morinda Citrifolia L.) Fruit Juice Against Cisplatin-Induced Nephrotoxicity

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