The effects of multimodal exercise on cognitive and physical functioning and brain-derived neurotrophic factor in older women: a randomised controlled trial

Vaughan, Sue; Wallis, Marianne; Polit, Denise F.; Steele, Michael; Shum, David; Morris, Norman

doi:10.1093/ageing/afu010

Cited by 180 publications

(184 citation statements)

References 23 publications

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“…This is supported by data showing that BDNF peripheral levels may increase after physical exercise (Schmolesky et al 2013;Vaughan et al 2014). In addition, it was demonstrated that the increase in BDNF after physical training correlates with improvements in cognitive functions in aged non pathological subjects (Vaughan et al 2014) as well as in patients affected by pathological conditions such as stroke (El-Tamawy et al 2014) and depression (Pereira et al 2013;Oral et al 2012). …”

Section: Introductionmentioning

confidence: 63%

The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson’s disease subjects

Angelucci

Piermaria

Gelfo

et al. 2016

Can. J. Physiol. Pharmacol.

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Keyword:https://mc06.manuscriptcentral.com/cjpp-pubs Moreover, parallel treatments in animals up-regulate brain-derived neurotrophic factor (BDNF). Thus, we investigated the effect of a motor rehabilitation protocol on PD symptoms and BDNF serum levels.Motor rehabilitation training consisted of a cycle of 20 days/month of physiotherapy divided in three daily sessions. Clinical data were collected at the beginning, at the end and at 90 days follow-up.BDNF serum levels were detected by ELISA at 0, 7, 14, 21, 30 and 90 days. The follow up period had a duration of 60 days (T30-T90). The results showed that at the end of the treatment (day 30 th ), an improvement in extrapyramidal signs (UPDRS III; UPDRS III -Gait and Balance items), motor (6 Minute Walking Test) and daily living activities (UPDRS II; PDQ-39) was observed. BDNF levels were increased at day 7 th as compared to baseline. After that, no changes in BDNF were observed during the treatment and in the successive follow-up. This study demonstrates that motor rehabilitation training is able to ameliorate PD symptoms and to increase temporarily BDNF serum levels. The latter effect may potentially contribute to the therapeutic action.

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Section: Introductionmentioning

confidence: 63%

The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson’s disease subjects

Angelucci

Piermaria

Gelfo

et al. 2016

Can. J. Physiol. Pharmacol.

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“…Exercise encourages neuron formation, grey matter and brain-derived neurotrophin factor (BDNF), a protein that keeps neurons alive and increases the growth of neurons and synapses in the area of the hippocampus where new information is stored. Vaughan, Wallis, Polit et al (2014) found that football improved cardio-vascular and muscular-skeletal fitness and affected aspects of brain function that are important for performance in competitive situations demanding skill and judgement. Krustrup, Aagaard, Nybo et al (2010) found that small-sided football produced high aerobic activity with mean heart rates of 80-85% of age-related maxima.…”

Section: Introductionmentioning

confidence: 99%

Walking football as sustainable exercise for older adults – A pilot investigation

Reddy

Dias

Holland

et al. 2017

European Journal of Sport Science

114

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The health benefits of playing football and the importance of exercise and social contact for healthy ageing are well established, but few older adults in the UK take enough exercise. Football is popular, flexible in format and draws players into engrossing, effortful and social exercise, but the physical demands of play at full speed may make it unsustainable for some older adults. Restricted to walking pace, will play still be engaging? Will health benefits be retained? Will physical demands remain manageable? This pilot study aims to investigate: 1) The experience of older adults playing walking football every week, is it sustainable and rewarding, 2) the intensity and locomotor pattern of walking football, 3) the scale and nature of walking football health benefits, 4) possible cognitive benefits of playing walking football through measures of processing speed, selective and divided attention and updating and inhibition components of executive function. 'Walking football' and 'waiting list' groups were compared before and after 12 weeks of one-hour per week football. Walking football was found to be engaging, sustainable for older adults and moderately intensive, however, selective health and cognitive benefits were not found from this brief intervention.

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“…Combined exercise training (CET) has demonstrated to be effective in increasing physical fitness and cognition (Vaughan et al 2014). Nutritional therapy, such as supplementation with taurine, can also decrease inflammation in several pathological conditions (Marcinkiewicz and Kontny 2014).…”

Section: Introductionmentioning

confidence: 99%

Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women

Chupel

Minuzzi

Furtado

et al. 2018

Appl. Physiol. Nutr. Metab.

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1Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women Authors:Matheus Abstract:Immunosenescence contribute to increase the blood-brain barrier (BBB) permeability, leading cognitive impairment and neurodegeneration. Thus, we investigated the anti-inflammatory effect of exercise and taurine supplementation on peripheral markers of blood-brain barrier, inflammation, and cognition of elderly women. Forty-eight elderly women (83.58±6.9 years) participated in the study, and were allocated into combined exercise training (CET: n=13), taurine supplementation (TAU: n=12), exercise training associated with taurine (CET+TAU: n=11), or control group (CG: n=12). Exercise was applied twice a week (multi-modal exercise). Taurine ingestion was 1.5g., once a day. Participants were evaluated before and after 14-weeks of intervention. Plasma levels of IL-1β, IL-1ra, IL-6, IL-10, IL-17, TNF-α, and serum concentration of S100β and neuron specific enolase (NSE) were determined. The mini mental state examination (MMSE) was also applied.Concentrations of S100β were maintained in all intervention groups, while a subtle increase in the CG was found. NSE levels increased only in TAU group (p<0.05). CET reduced TNF-α, IL-6, and IL-1β/IL-1ra, IL-6/IL10, TNF-α/IL-10 ratios (p<0.05). TAU decreased the IL-1β/IL-1ra ratio (p<0.05). MMSE score increased only in CET+TAU group (p<0.05). Multiple regression analysisshowed that there was a trend for changes in IL-1β and CCI to be independently associated with changes in S100β. Exercise and taurine decreased inflammation, and maintained the BBB integrity in elderly women. Exercise emerged as an important tool to improve brain health even when started at advanced ages.

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The effects of multimodal exercise on cognitive and physical functioning and brain-derived neurotrophic factor in older women: a randomised controlled trial

Abstract: Australian and New Zealand Clinical Trial Registration Number: ANZCTR12612000451808.

Cited by 180 publications

References 23 publications

The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson’s disease subjects

The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson’s disease subjects

Walking football as sustainable exercise for older adults – A pilot investigation

Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women

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