The Effects of Multiple Administrations of Sevoflurane to Cynomolgus Monkeys

Soma, Lawrence R.; Tierney, William J.; Hogan, G.K.; Satoh, Nobukatsu

doi:10.1213/00000539-199508000-00024

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…MAC of sevoflurane has not been established in rhesus macaques, but has been reported as 2% in cynomolgus monkeys, a value close to the 2% required for maintenance in this study. 15…”

Section: Discussionmentioning

confidence: 99%

Comparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure

et al. 2017

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Volatile agents for anaesthesia are widely used for anaesthetizing laboratory primates, and isoflurane is one of the most frequently used agents. Sevoflurane has been shown to offer a more rapid recovery than isoflurane in a number of species, but no comparisons have been made in non-human primates. This study compared the recovery characteristics of isoflurane and sevoflurane in rhesus macaques undergoing experimental neurosurgery. Twelve primates (7 males and 5 females) were randomly allocated to the treatment groups. They were sedated with ketamine (10 mg/kg) and anaesthesia was induced with propofol (usually 8 mg/kg intravenously [IV]). Anaesthesia was maintained with either sevoflurane (SEVO) (2.2 ± 0.4%) or isoflurane (ISO) (1.2 ± 0.2%) and alfentanil (0.2-0.5 µg/kg/min IV) for 332-592 min. Animals were mechanically ventilated. Meloxicam (0.3 mg/kg) and methylprednisolone infusion (5.4 mg/kg/h) were also administered. Time to extubation after cessation of anaesthesia was significantly shorter with sevoflurane (ISO: 7.0 ± 1.8 min; SEVO: 3.6 ± 1.5; *P = 0.005) as was the time to the animal sitting unaided (ISO: 15.7 ± 8.2 min; SEVO: 7.1 ± 1.7 min; *P = 0.004) . No significant difference in the quality of recovery following isoflurane or sevoflurane anaesthesia was found. In conclusion, isoflurane and sevoflurane are both suitable volatile agents for the maintenance of general anaesthesia in rhesus macaques undergoing experimental neurosurgical procedures. The two volatile agents presented a similar emergence quality profile, however sevoflurane anaesthesia was associated with a faster recovery, offering the possibility of conducting earlier post-operative neurological assessment.

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“…MAC of sevoflurane has not been established in rhesus macaques, but has been reported as 2% in cynomolgus monkeys, a value close to the 2% required for maintenance in this study. 15…”

Section: Discussionmentioning

confidence: 99%

Comparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure

et al. 2017

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“…It is also in uenced by other drugs used perioperatively (Baker & Van Dyke 1994). Sevo urane is commonly thought to be less hepatotoxic than halothane and en urane although, recently, liver dysfunction has been reported after sevourane anaesthesia (Kharasch et al 1995a, Soma et al 1995.…”

Section: Discussionmentioning

confidence: 99%

Effects of repetitive sevoflurane anaesthesia on immune response, select biochemical parameters and organ histology in mice

et al. 2003

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SummaryAnimal and technical models often require repeated anaesthetic administrations for surgical procedures. As there is evidence for immunomodulatory effects of anaesthesia, the effects of repeated exposure to sevo urane anaesthesia on the immune response in mice were studied. Sevo urane was administered in vivo under conditions that simulate those in clinical procedures. Adult male mice were anaesthetized with 3% sevo urane in oxygen for 40 min weekly for 3 weeks. Untreated animals served as controls. After sevo urane anaesthesia, peripheral blood leukocyte counts, the composition and in vitro function of spleen cells (lymphocytes and macrophages) and the in vivo immune response to a conventional T-dependent antigen were assessed. In addition, liver, spleen and kidney histopathology and also hepatic and renal function were studied. Three days after the latest anaesthetic procedure, the absolute number of both leukocyte and lymphocyte counts were reduced in peripheral blood. Splenic cell composition (LB, LTCD3‡ , LTCD4 ‡ and LTCD8 ‡ ), macrophage function and the mitogen-induced lymphoprolipherative response were preserved. Yet, the in vivo humoral response to a conventional antigen was augmented following the antigenic challenge. Assessment at day 9 after the last anaesthetic procedure revealed the persistence of the humoral response alteration. Nevertheless, sevo urane-treated animals showed no evidence of histological changes or alteration in hepatic or renal function.

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“…The concentration of inhalant required to prevent purposeful movement in response to a supramaximal noxious (painful) stimulus in 50% of subjects is considered to be 1 MAC. The MAC of sevoflurane is 2.0% in cynomolgus macaques (Macaca fascicularis) (Soma et al 1995) and 1.8% in humans (Katoh & Ikeda 1987). The authors are not aware of any study describing MAC in prosimians.…”

Section: Introductionmentioning

confidence: 99%

The minimum alveolar concentration of sevoflurane in ring-tailed lemurs (Lemur catta) and aye-ayes (Daubentonia madagascariensis)

Chinnadurai

Williams

2016

Veterinary Anaesthesia and Analgesia

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The Effects of Multiple Administrations of Sevoflurane to Cynomolgus Monkeys

Cited by 8 publications

References 19 publications

Comparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure

Comparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure

Effects of repetitive sevoflurane anaesthesia on immune response, select biochemical parameters and organ histology in mice

The minimum alveolar concentration of sevoflurane in ring-tailed lemurs (Lemur catta) and aye-ayes (Daubentonia madagascariensis)

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