2023
DOI: 10.1101/2023.11.11.566703
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The effects of mutation and recombination rate heterogeneity on the inference of demography and the distribution of fitness effects

Vivak Soni,
Susanne P. Pfeifer,
Jeffrey D. Jensen

Abstract: Disentangling the effects of demography and selection has remained a focal point of population genetic analysis. Knowledge about mutation and recombination is essential in this endeavour; however, despite clear evidence that both mutation and recombination rates vary across genomes, it is common practice to model both rates as fixed. In this study, we quantify how this unaccounted for rate heterogeneity may impact inference using common approaches for inferring selection (DFE-alpha, Grapes, and polyDFE) and/or… Show more

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