The effects of n-butanol on oxidative stress and apoptosis in zebra fish (Danio rerio) larvae

Köktürk, Mine; Alak, Gonca; Atamanalp, Muhammed

doi:10.1016/j.cbpc.2019.108636

Cited by 10 publications

(6 citation statements)

References 61 publications

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“…Similarly, we found that n‐butanol had effects on hepatocytes and necrotic hepatocytes at high doses (500, 750, and 1,000 mg/L) in the form of bulging vacuoles. Our liver histopathology findings are supported by Köktürk et al (2020), who found that n‐butanol causes antioxidant enzymes to diminish, increasing the malondialdehyde level, an indicator of reactive oxygen radicals and apoptotic cells in the liver region. As a known condition, the liver exposed to excessive amounts of alcohol changes such as oxidative stress and inflammation (Ilaiyaraja and Khanum 2011; Cichoż‐Lach and Michalak 2014).…”

Section: Discussionsupporting

confidence: 85%

“…The experiment was carried out in the Zebrafish Research and Toxicology Experiment Unit of the Atatürk University Fisheries Faculty. Mature Zebrafish were kept in a recirculation system with aquariums (Pentair USA) with a photoperiod of 14 h light : 10 h dark in a constant water temperature of 28.5°C (Köktürk et al 2020).…”

Section: Methodsmentioning

confidence: 99%

“…The treatment groups were administered n‐butanol at different concentrations (10, 50, 250, 500, 750, 1,000, and 1,250 mg/L). At the end of the trial, malformation, brain and liver histopathology, eye size, and heart rate parameters were examined by taking into account sublethal doses; the highest dose of 1,250 mg/L was not evaluated (Köktürk et al 2020).…”

Section: Methodsmentioning

confidence: 99%

“…On the first day of the experiment, randomly selected eggs were transferred to E3 solution (5 mM NaCl, 0.17 mM KCl, 0.33 mM CaCl 2 , 0.33 mM MgSO 4 , 0.01% methylene blue) at the end of the fourth hour (in the blastula stage of the eggs). As in Köktürk et al (2020), all experimental groups were treated at the same temperature (28.5°C) and photoperiod (14 h light : 10 h dark).…”

Section: Methodsmentioning

confidence: 99%

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Teratogenic and Neurotoxic Effects of n‐Butanol on Zebrafish Development

et al. 2021

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In recent years, n‐butanol, a type of alcohol, has been widely used from the chemical industry to the food industry. In this study, toxic effects of n‐butanol's different concentrations (10, 50, 250, 500, 750, 1,000, and 1,250 mg/L) in Zebrafish Danio rerio embryos and larvae were investigated. For this purpose, Zebrafish embryos were exposed to n‐butanol in acute semistatic applications. Teratogenic effects such as cardiac edema, scoliosis, lordosis, head development abnormality, yolk sac edema, and tail abnormality were determined at different time intervals (24, 48, 72, 96, and 120 h). Additionally, histopathological abnormalities such as vacuole formation in brain tissue and necrosis in liver tissue were observed at high doses (500, 750, and 1,000 mg/L) in all treatment groups at 96 h. It was determined that heart rate decreased at 48, 72, and 96 h due to an increase in concentration. In addition, alcohol‐induced eye size reduction (microphthalmia) and single eye formation (cyclopia) are also among the effects observed in our research findings. In conclusion, n‐butanol has been observed to cause intense neurotoxic, teratogenic, and cardiotoxic effects in Zebrafish embryos and larvae.

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Section: Discussionsupporting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Teratogenic and Neurotoxic Effects of n‐Butanol on Zebrafish Development

et al. 2021

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“…Therefore, the detection of different alcohol groups is required to assess the effects of different alcohol concentrations on the overall health and growth of cultured cells. High doses of n-butanol can lead to apoptosis [ 34 ]. There are many studies on the alterations in hydrophobicity and molecular integrity in the presence of n-propanol and other alcohols [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Three-in-One Sensor on t-ZnO for Ultraviolet and VOC Sensing for Bioengineering Applications

Nagpal,

Lupan,

Bîrnaz

et al. 2024

Biosensors

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Zinc oxide (ZnO) is considered to be one of the most explored and reliable sensing materials for UV detection due to its excellent properties, like a wide band gap and high exciton energy. Our current study on a photodetector based on tetrapodal ZnO (t-ZnO) reported an extremely high UV response of ~9200 for 394 nm UV illumination at 25 °C. The t-ZnO network structure and morphology were investigated using XRD and SEM. The sensor showed a UV/visible ratio of ~12 at 25 °C for 394 nm UV illumination and 443 nm visible illumination. By increasing the temperature, monotonic decreases in response and recovery time were observed. By increasing the bias voltage, the response time was found to decrease while the recovery time was increased. The maximum responsivity shifted to higher wavelengths from 394 nm to 400 nm by increasing the operating temperature from 25 °C to 100 °C. The t-ZnO networks exhibited gas-sensing performances at temperatures above 250 °C, and a maximum response of ~1.35 was recorded at 350 °C with a good repeatability and fast recovery in 16 s for 100 ppm of n-butanol vapor. This study demonstrated that t-ZnO networks are good biosensors that can be used for diverse biomedical applications like the sensing of VOCs (volatile organic compounds) and ultraviolet detection under a wide range of temperatures, and may find new possibilities in biosensing applications.

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Nanotoxicology

Alak

2024

Springer Water

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The effects of n-butanol on oxidative stress and apoptosis in zebra fish (Danio rerio) larvae

Cited by 10 publications

References 61 publications

Teratogenic and Neurotoxic Effects of n‐Butanol on Zebrafish Development

Teratogenic and Neurotoxic Effects of n‐Butanol on Zebrafish Development

Multifunctional Three-in-One Sensor on t-ZnO for Ultraviolet and VOC Sensing for Bioengineering Applications

Nanotoxicology

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