The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial

Abstract

Nabilone is effective in improving sleep in patients with FM and is well tolerated. Low-dose nabilone given once daily at bedtime may be considered as an alternative to amitriptyline. Longer trials are needed to determine the duration of effect and to characterize long-term safety.

The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease

“…Although adverse events in the active treatment group were not serious, they were common (77). In studies examining the endocannabinoid-based drug "Nabilone" on pain outcomes in fibromyalgia, the statistically significant effects were outweighed when side effects were taken into consideration (78)(79)(80). In a separate review of cannabinoid-based therapies in chronic pain conditions, three of which were rheumatic pain (2 fibromyalgia, 1 RA), concluded that while the majority demonstrated improvements in pain, no direct evidence on effects of herbal marijuana in rheumatic pain (78).…”

Fibromiyaljide Farmakolojik Tedavi

“…Sentetik bir tetrahidrokanabinol türevi olan Nabilon fibromiyalji tedavisinde iki çalışma ile değerlendirilmiştir. Hastaların yaklaşık 2 hafta takip edildiği çalışmada nabilonun amitriptiline göre uyku problemlerinde daha etkili olduğu, ağrı ve yaşam kalitesi üzerine ise üstünlüğü olmadığı gösterilirken; ikinci çalışmada plasebo ile karşılaştırıldığında ağrı ve yaşam kalitesinde anlamlı düzelme sağlamıştır 81,82 . Sık görülen yan etkileri arasında baş dönmesi, sersemlik ve bulantı sayılabilir.…”

Clinical Use of Cannabinoids for Symptom Control in Multiple Sclerosis

“…Therefore, cannabinoids may have a major role for patients who suffer sleep disturbance because of chronic pain or other chronic illness [8]. Ware et al [25] showed the benefit of nabilone in helping sleep in fibromyalgia.…”