The effects of nano‐curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double‐blind clinical trial

Bateni, Zohre; Rahimi, Hamid Reza; Hedayati, Mehdi; Afsharian, Shila; Goudarzi, Razieh; Sohrab, Golbon

doi:10.1002/ptr.7109

Cited by 39 publications

(43 citation statements)

References 24 publications

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“…From all seven studies that evaluated nano-curcumin supplementation effects on the glycemic profile in our analysis, six studies [14,[31][32][33][34][35] showed significant improvements in the glycemic profile. From all included studies, only one study [36] reported no significant differences in the glycemic profile, including FBS, HbA1c, HOMA-IR, and HOMA-β following nano-curcumin supplementation compared to the placebo. These findings suggest the effectiveness of nano-curcumin supplementation in improving the glycemic profile.…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials

et al. 2021

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Background: Previous studies have indicated that curcumin supplementation may be beneficial for cardiometabolic health; however, current evidence regarding the effects of its nanorange formulations, popularly known as “nano-curcumin”, remains unclear. This systematic review and meta-analysis aimed to determine the impact of nano-curcumin supplementation on risk factors for cardiovascular disease. Methods: PubMed, Scopus, Embase, and ISI web of science were systematically searched up to May 2021 using relevant keywords. All randomized controlled trials (RCTs) investigating the effects of nano-curcumin supplementation on cardiovascular disease risk factors were included. Meta-analysis was performed using random-effects models, and subgroup analysis was performed to explore variations by dose and baseline risk profiles. Results: According to the results of this study, nano-curcumin supplementation was associated with improvements in the glycemic profile by decreasing fasting blood glucose (FBG) (WMD: −18.14 mg/dL; 95% CI: −29.31 to −6.97; p = 0.001), insulin (WMD: −1.21 mg/dL; 95% CI: −1.43 to −1.00; p < 0.001), and HOMA-IR (WMD: −0.28 mg/dL; 95% CI: −0.33 to −0.23; p < 0.001). Interestingly, nano-curcumin supplementation resulted in increases in high-density lipoprotein (HDL) (WMD: 5.77 mg/dL; 95% CI: 2.90 to 8.64; p < 0.001). In terms of other lipid profile markers (triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL)), subgroup analyses showed that nano-curcumin supplementation had more favorable effects on lipid profiles in individuals with dyslipidemia at baseline. Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: −1.29 mg/L; 95% CI: −2.15 to −0.44; p = 0.003) and interleukin-6 (IL-6) (WMD: −2.78 mg/dL; 95% CI: −3.76 to −1.79; p< 0.001). Moreover, our results showed the hypotensive effect of nano-curcumin, evidenced by a decrease in systolic blood pressure (SBP). Conclusions: In conclusion, our meta-analysis suggests that nano-curcumin supplementation may decline cardiovascular disease risk by improving glycemic and lipid profiles, inflammation, and SBP. Future large-scale investigations with longer durations are needed to expand on our findings.

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Section: Discussionmentioning

confidence: 99%

“…The detailed characteristics of the nine RCTs [14,[29][30][31][32][33][34][35][36], including 11 intervention arms, are summarized in Table 1. There were 510 participants included (cases = 269 and control = 241) in these RCTs dated between 2016 and 2021.…”

Section: Study Characteristicsmentioning

confidence: 99%

The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials

et al. 2021

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“…Nano-based formulations for the MS that are biodegradable, biocompatible, nontoxic, and stable after oral administration should be developed focusing on the multifactorial effects rather than a single factor ( 128 ). A recent study by Bateni et al reported that nano-micelle curcumin supplement at a dose of 80 mg/day significantly improved serum triglycerides in patients with MS, although no significant difference was observed in anthropometric measurements, blood pressure, and several biochemical factors ( 129 ). Nano curcumin supplementation (80 mg/day for 6 weeks) along with regular exercise significantly reduced inflammation in an elderly woman with MS, as well as decreased the percentage of fat and IL-6, and increased IL-10 and BDNF ( 86 ).…”

Section: Other Clinical Studiesmentioning

confidence: 99%

Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward Personalized Prevention and Treatment Management

Nurcahyanti

Cokro

Wulanjati³

et al. 2022

Front. Nutr.

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The metabolic syndrome (MS) is a multifactorial syndrome associated with a significant economic burden and healthcare costs. MS management often requires multiple treatments (polydrug) to ameliorate conditions such as diabetes mellitus, insulin resistance, obesity, cardiovascular diseases, hypertension, and non-alcoholic fatty liver disease (NAFLD). However, various therapeutics and possible drug-drug interactions may also increase the risk of MS by altering lipid and glucose metabolism and promoting weight gain. In addition, the medications cause side effects such as nausea, flatulence, bloating, insomnia, restlessness, asthenia, palpitations, cardiac arrhythmias, dizziness, and blurred vision. Therefore, is important to identify and develop new safe and effective agents based on a multi-target approach to treat and manage MS. Natural products, such as curcumin, have multi-modalities to simultaneously target several factors involved in the development of MS. This review discusses the recent preclinical and clinical findings, and up-to-date meta-analysis from Randomized Controlled Trials regarding the effects of curcumin on MS, as well as the metabonomics and a pharma-metabolomics outlook considering curcumin metabolites, the gut microbiome, and environment for a complementary personalized prevention and treatment for MS management.

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“…Furthermore, curcumin incorporated with a nano-delivery system can enhance water solubility, decrease degradation, control slow release, and increase absorptive efficiency ( Chen et al, 2020 ; Li et al, 2020 ; Quispe et al, 2021 ), thereby increasing circulation time, pharmacokinetics, and biodistribution. Cumulative evidence unveiled that encapsulated curcumin with a nano-delivery system has more significant effects than native curcumin in the clinical trials for the treatment in metabolic syndrome to decrease triglyceride levels in serum ( Bateni et al, 2021 ); in coronary elective angioplasty treatment to improve total cholesterol, triglycerides, and antioxidative capacity ( Helli et al, 2021 ); and in knee osteoarthritis treatment to improve the severity of symptoms ( Hashemzadeh et al, 2020 ). Curcumin is re-proposed as a potential antiviral key for the treatment of SARS-CoV-2 based on its relation to the infection pathways.…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Prospects of Curcuminoids for the Remedy of COVID-19: Truth or Myth

Fu¹,

Kang³

et al. 2022

Front. Pharmacol.

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Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a positive-strand RNA virus, and has rapidly spread worldwide as a pandemic. The vaccines, repurposed drugs, and specific treatments have led to a surge of novel therapies and guidelines nowadays; however, the epidemic of COVID-19 is not yet fully combated and is still in a vital crisis. In repositioning drugs, natural products are gaining attention because of the large therapeutic window and potent antiviral, immunomodulatory, anti-inflammatory, and antioxidant properties. Of note, the predominant curcumoid extracted from turmeric (Curcuma longa L.) including phenolic curcumin influences multiple signaling pathways and has demonstrated to possess anti-inflammatory, antioxidant, antimicrobial, hypoglycemic, wound healing, chemopreventive, chemosensitizing, and radiosensitizing spectrums. In this review, all pieces of current information related to curcumin-used for the treatment and prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through in vitro, in vivo, and in silico studies, clinical trials, and new formulation designs are retrieved to re-evaluate the applications based on the pharmaceutical efficacy of clinical therapy and to provide deep insights into knowledge and strategy about the curcumin’s role as an immune booster, inflammatory modulator, and therapeutic agent against COVID-19. Moreover, this study will also afford a favorable application or approach with evidence based on the drug discovery and development, pharmacology, functional foods, and nutraceuticals for effectively fighting the COVID-19 pandemic.

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The effects of nano‐curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double‐blind clinical trial

Abstract: curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double-blind clinical trial.

Cited by 39 publications

References 24 publications

The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials

The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials

Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward Personalized Prevention and Treatment Management

Pharmaceutical Prospects of Curcuminoids for the Remedy of COVID-19: Truth or Myth

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