The Effects of Natural Antioxidants from Tomato Extract in Treated but Uncontrolled Hypertensive Patients

Paran, Esther; Novack, Victor; Engelhard, Yechiel N.; Hazan‐Halevy, Inbal

doi:10.1007/s10557-008-6155-2

Cited by 119 publications

(95 citation statements)

References 27 publications

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“…Tomato extract supplementation was associated with a clinically significant reduction of systolic and diastolic BP in hypertensive patients [15]. Garlic extract has also been associated with reduced systolic BP in patients with hypertension [16].…”

Section: + Modelmentioning

confidence: 98%

“…Raw ingredients in gazpacho exert a potentially valuable functional activity. Adding tomato extract to the diet of moderate hypertensive subjects is associated with a clinically significant reduction of systolic and diastolic BP [15]. Supplementing the diet of patients with uncontrolled hypertension with aged garlic extract also reduces systolic BP [16].…”

Section: Introductionmentioning

confidence: 99%

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Gazpacho consumption is associated with lower blood pressure and reduced hypertension in a high cardiovascular risk cohort. Cross-sectional study of the PREDIMED trial

Medina‐Remón

Vallverdú‐Queralt

Arranz

et al. 2013

Nutrition, Metabolism and Cardiovascular Diseases

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(R.M. Lamuela-Raventos). 1 On behalf of the PREDIMED Study Investigators. + MODELPlease cite this article in press as: Medina-Remón A, et al., Gazpacho consumption is associated with lower blood pressure and reduced hypertension in a high cardiovascular risk cohort. Abstract Background and aim: Hypertension is a major public health problem and a leading cause of death and disability in both developed and developing countries, affecting onequarter of the world's adult population. Our aim was to evaluate whether the consumption of gazpacho, a Mediterranean vegetable-based cold soup rich in phytochemicals, is associated with lower blood pressure (BP) and/or reduced prevalence of hypertension in individuals at high cardiovascular risk. Methods and results:We selected 3995 individuals (58% women, mean age 67 y) at high cardiovascular risk (81% hypertensive) recruited into the PREDIMED study. BP, weight, and dietary and physical activity data were collected. In multivariate linear regression analyses, after adjustment, moderate and high gazpacho consumption categories were associated with reduced mean systolic BP of À1.9 mm Hg [95% confidence interval (CI): À3.4; À0.6] and À2.6 mm Hg (CI: À4.2; À1.0), respectively, and reduced diastolic BP of À1.5 mm Hg (CI: À2.3; À0.6) and À1.9 mm Hg (CI: À2.8; À1.1). By multiple-adjusted logistic regression analysis, gazpacho consumption was associated with a lower prevalence of hypertension, with OR Z 0.85 (CI: 0.73; 0.99) for each 250 g/week increase and OR Z 0.73 (CI: 0.55; 0.98) for high gazpacho consumption groups compared to the no-consumption group. Conclusions: Gazpacho consumption was inversely associated with systolic and diastolic BP and prevalence of hypertension in a cross-sectional Mediterranean population at high cardiovascular risk. The association between gazpacho intake and reduction of BP is probably due to synergy among several bioactive compounds present in the vegetable ingredients used to make the recipe. ª

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Section: + Modelmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Gazpacho consumption is associated with lower blood pressure and reduced hypertension in a high cardiovascular risk cohort. Cross-sectional study of the PREDIMED trial

Medina‐Remón

Vallverdú‐Queralt

Arranz

et al. 2013

Nutrition, Metabolism and Cardiovascular Diseases

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“…Tomato and its products are important dietary sources of antioxidants such as α-tocopherol and the carotenoids beta-carotene, phytotene and phytofluene [9]. Fluted pumpkin extract had the highest vitamin E content (5.07±0.04mg/100ml), and vitamin E is considered the 'standard antioxidant' to which other compounds with antioxidant activities are compared, especially in terms of its biological activity and clinical relevance [10].…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of vitamins C, E and pro-vitamin A in extracts of fluted pumpkin (Telfairia occidentalis), tomato (Lycopersicum esculentum) and eggplant (Solanum melongena)

Madukwe

Nwabunze²,

Onyibalu³

2013

International Journal of Basic and Applied Sciences

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Background: Vegetables, an important source of our diet contain some beneficial antioxidants. Objectives: This study evaluated pro-vitamin A, vitamins E and C content of extracts of tomato, fluted pumpkin and eggplant and bioavailability of these antioxidants in rats. Methods: The antioxidant content of the vegetable aqueous extracts, serum, liver, faecal and urinary antioxidants were determined using standard procedures. Results: The aqueous extract of tomato had the highest pro-vitamin A content (0.33±0.01mg/100ml) and fluted pumpkin extract had the highest vitamins E and C (5.07±0.04mg/100ml) and (40±0.02mg/100ml) respectively. The faecal and urinary vitamin A for the rats fed vegetable extracts was higher than their intake. Rats fed tomato extract consumed more (0.09±0.02mg) pro-vitamin A and had the highest liver vitamin A (2.33±0.01mg). This group of rats also had the least vitamin E intake (0.20±0.00mg) with high urinary (0.34±0.01mg) and faecal (0.65±0.01mg) excretions leading to negative vitamin E retention. In addition, rats fed tomato extracts consumed highest vitamin C (10.10±0.80mg) which contributed to the high serum concentration of vitamin C (0.85±0.00mg). Conclusion:Further studies on the specific bioavailability of vitamin A and vitamin E (α-, β, γ-and δ-tocopherols) differentials in the vegetable extracts should be carried out.

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“…Dietary sources include tomatoes, guava, pink grapefruit, watermelon, apricots and papaya in high concentrations [237][238][239][240][241] . Lycopene produces a significant reduction in BP, serum lipids and oxidative stress markers [237][238][239][240][241] . Paran et al [241] evaluated 30 subjects with Grade Ⅰ hypertension, age 40-65, taking no antihypertensive or anti-lipid medications treated with a tomato lycopene extract (10 mg lycopene) for eight weeks.…”

Section: Lycopenementioning

confidence: 99%

“…Englehard gave a tomato extract to 31 hypertensive subjects over 12 wk demonstrating a significant BP reduction of 10/4 mmHg [238] . Patients on various anti-hypertensive agents including ACEI, CCB and diuretics had a significant BP reduction of 5.4/3 mmHg over 6 wk when administered a standardized tomato extract [239] . Other studies have not shown changes in BP with lycopene [240] .…”

Section: Lycopenementioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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The Effects of Natural Antioxidants from Tomato Extract in Treated but Uncontrolled Hypertensive Patients

Cited by 119 publications

References 27 publications

Gazpacho consumption is associated with lower blood pressure and reduced hypertension in a high cardiovascular risk cohort. Cross-sectional study of the PREDIMED trial

Gazpacho consumption is associated with lower blood pressure and reduced hypertension in a high cardiovascular risk cohort. Cross-sectional study of the PREDIMED trial

Bioavailability of vitamins C, E and pro-vitamin A in extracts of fluted pumpkin (Telfairia occidentalis), tomato (Lycopersicum esculentum) and eggplant (Solanum melongena)

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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