The effects of neonatal amygdala or hippocampus lesions on adult social behavior

Bliss‐Moreau, Eliza; Moadab, Gilda; Santistevan, Anthony; Amaral, David G.

doi:10.1016/j.bbr.2016.11.052

Cited by 39 publications

(34 citation statements)

References 50 publications

(82 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmacologically increasing amygdala activity results in decreased social interaction in monkeys 58 , which provides a potential mechanism to explain our results showing increased functional connectivity between the amygdala and prefrontal area 46, as well as the amygdala and caudate among ZIKV-infected infant RMs. In addition, previous studies of RMs with selective lesions of the amygdala or hippocampus during infancy report similar alterations in socioemotional behavior [59][60][61][62][63] , further supporting the notion that behavioral changes in the current study may be the result of structural and functional alterations found in these limbic regions after postnatal ZIKV infection. Overall, these findings indicate that ZIKV infection during this early and vulnerable period of rapid postnatal brain development can have a lasting impact on socioemotional behavior.…”

Section: Discussionsupporting

confidence: 88%

Long-term alterations in brain and behavior after postnatal Zika virus infections in infant macaques

Raper

Kovacs-Balint

Mavinger

et al. 2019

Preprint

View full text Add to dashboard Cite

Considering the impact that Zika virus (ZIKV) infection has on the fetal nervous system and given that the postnatal period is also a time of rapid brain growth, it is important to understand the potential neurobehavioral consequences of ZIKV infection during infancy. Using a rhesus macaque (RM) model, we showed that postnatal ZIKV infection resulted in long-term behavioral changes, including increased emotional reactivity, decreased social contact, loss of balance, and deficits in visual recognition memory at one year of age. Structural and functional MRI showed that ZIKV-infected infant RMs had persistent enlargement of lateral ventricles, smaller volumes and altered functional connectivity between brain areas important for socioemotional behavior and cognitive function (e.g. amygdala, hippocampus, cerebellum). Neuropathological changes corresponded with neuroimaging results and were consistent with the behavioral and memory deficits. Overall, this study demonstrates that postnatal ZIKV infection of infants in this model has long lasting neurodevelopmental consequences.

show abstract

Section: Discussionsupporting

confidence: 88%

Long-term alterations in brain and behavior after postnatal Zika virus infections in infant macaques

Raper

Kovacs-Balint

Mavinger

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Lesion placement has been confirmed at various time points using MRI and more recently by direct histological analysis (Bliss-Moreau, Moadab, Santistevan, & Amaral, in press). Edema associated with brain lesions was measured 10 days post-surgery, using T2-weighted magnetic resonance images.…”

Section: Methodsmentioning

confidence: 99%

Early amygdala or hippocampus damage influences adolescent female social behavior during group formation.

Moadab¹,

Bliss‐Moreau²,

Bauman³

et al. 2017

Behavioral Neuroscience

Self Cite

View full text Add to dashboard Cite

This study continues a longitudinal analysis of rhesus macaque social behavior following bilateral neonatal ibotenic acid lesions of the amygdala or hippocampus, or sham operations. The social behavior of female subjects was evaluated at a critical developmental time point—the transition to adulthood. At approximately 4 years of age, female subjects were housed in small groups with other female subjects and reproductively viable adult males. As compared to neurologically intact control animals and animals with early amygdala damage, animals with early hippocampal damage were more social with their female peers. In contrast, as compared to control animals, animals with early amygdala damage spent less time with the males, engaged less frequently in behaviors typical of reproductive consortships, had higher frequencies of self-directed stereotypies, and became pregnant later. Males also generated fewer communicative signals towards animals with early amygdala damage than to control animals and animals with early hippocampus damage. Rates of sexual behavior were generally low for all animals and there were no lesion-based differences in their frequencies. Discriminant function analyses demonstrated that patterns of affiliative social behaviors differed across the three experimental groups, both in terms of the social behaviors directed to the males, and the social behaviors generated by the males towards the females. In four of the five social groups, amygdala-lesioned animals were lowest ranked, potentially contributing to reduced sociability interactions with males. Other potential mechanisms and the experiments needed to elucidate them are discussed.

show abstract

“…We used the Observer 5.0 software package (Noldus, Wageningen, NL) and our standard behavioral ethogram (Bliss-Moreau et al 2017) (Supplementary Table 1), in order to analyze each monkey’s behavior during the individual exploration session. Quantitative analyses of exploratory behavior demonstrated that both groups of animals were motivated to explore the novel environment.…”

Section: Resultsmentioning

confidence: 99%

Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys

et al. 2017

Self Cite

View full text Add to dashboard Cite

Hippocampal damage in adult humans impairs episodic and semantic memory, whereas hippocampal damage early in life impairs episodic memory but leaves semantic learning relatively preserved. We have previously shown a similar behavioral dissociation in nonhuman primates. Hippocampal lesion in adult monkeys prevents allocentric spatial relational learning, whereas spatial learning persists following neonatal lesion. Here, we quantified the number of cells expressing the immediate-early gene c-fos, a marker of neuronal activity, to characterize the functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion. Ninety minutes before brain collection, three control and four adult monkeys with bilateral neonatal hippocampal lesions explored a novel environment in order to activate brain structures involved in spatial learning. Three other adult monkeys with neonatal hippocampal lesions remained in their housing quarters. In unlesioned monkeys, we found high levels of c-fos expression in the intermediate and caudal regions of the entorhinal cortex, and in the perirhinal, parahippocampal and retrosplenial cortices. In lesioned monkeys, spatial exploration induced an increase in c-fos expression in the intermediate field of the entorhinal cortex, the perirhinal, parahippocampal and retrosplenial cortices, but not in the caudal entorhinal cortex. These findings suggest that different regions of the medial temporal lobe memory system may require different types of interaction with the hippocampus in support of memory. The caudal perirhinal cortex, the parahippocampal cortex and the retrosplenial cortex may contribute to spatial learning in absence of functional hippocampal circuits, whereas the caudal entorhinal cortex may require hippocampal output to support spatial learning.

show abstract

The effects of neonatal amygdala or hippocampus lesions on adult social behavior

Cited by 39 publications

References 50 publications

Long-term alterations in brain and behavior after postnatal Zika virus infections in infant macaques

Long-term alterations in brain and behavior after postnatal Zika virus infections in infant macaques

Early amygdala or hippocampus damage influences adolescent female social behavior during group formation.

Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys

Contact Info

Product

Resources

About