2015
DOI: 10.1165/rcmb.2014-0280oc
|View full text |Cite
|
Sign up to set email alerts
|

The Effects of Nerve Growth Factor on Nicotinic Synaptic Transmission in Mouse Airway Parasympathetic Neurons

Abstract: In autonomic ganglia, acetylcholine (ACh) is released from preganglionic nerve terminals and binds to nicotinic ACh receptors (nAChRs) on postganglionic neurons, resulting in a brief, short-lived synaptic potential (fast excitatory postsynaptic potential [fEPSP]). Although nerve growth factor (NGF) is known to affect sensory and sympathetic nerves, especially during development, little is known regarding its effect on parasympathetic nerves, especially on adult neurons. Elevated levels of NGF and NGF-mediated … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
7
0

Year Published

2016
2016
2019
2019

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 8 publications
(7 citation statements)
references
References 31 publications
0
7
0
Order By: Relevance
“…The preparation of trachea parasympathetic postganglionic neurons was performed as described with modifications (Weigand et al, 2015). Briefly, mice on C57B6 genetic background (male and female, 3-4 weeks old) were anesthetized with isoflurane and then sacrificed with cervical dislocation.…”
Section: Electrophysiologymentioning
confidence: 99%
“…The preparation of trachea parasympathetic postganglionic neurons was performed as described with modifications (Weigand et al, 2015). Briefly, mice on C57B6 genetic background (male and female, 3-4 weeks old) were anesthetized with isoflurane and then sacrificed with cervical dislocation.…”
Section: Electrophysiologymentioning
confidence: 99%
“…Recent studies have shown that NGF can activate a parasympathetic tone. In mouse airway parasympathetic ganglia, the cholinergic neurons expressed TrkA and exposure to NGF potentiated synaptic transmission, enhancing their excitability [ 134 , 135 ]. In vivo administration of NGF altered dendritic length and sprouting in the bronchial ganglionic neurons of guinea pigs [ 134 ].…”
Section: Ngf and Its Direct And Indirect Effects On Immune Responsmentioning
confidence: 99%
“…For example, NGF can increase expression of neuropeptides, such as SP, calcitonin gene-related peptide (CGRP), and neurokinin A, in sensory nerve fibers in the lung; increased levels of these neuropeptides can increase smooth muscle contraction via direct action on airway smooth muscle or indirectly via action on cholinergic nerve fibers (15,29,30,51,126,154). NGF has also been shown to cause a phenotypic switch in sensory neurons innervating the trachea in the guinea pig, resulting in more cells expressing SP (120), and in the mouse NGF directly affects synaptic transmission in airway parasympathetic nerves (233).…”
Section: Mechanisms Of Neuronal Plasticity As Mediators Of Op-inducedmentioning
confidence: 99%