The Effects of Nettle Extract Consumption on Liver PPARs, SIRT1, ACOX1 and Blood Lipid Levels in Male and Female C57Bl6 Mice

Drozdek, Sandra Domjanić; Odeh, Dyana; Đikić, Domagoj; Gračan, Romana; Oršolić, Nada; Dragović–Uzelac, Verica; Feher-Turković, Lana; Dragičević, Petar; Jurčević, Irena Landeka

doi:10.3390/nu14214469

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…Additionally, in mouse models of CVD both blackberry and gallic acid supplementation reduced atherosclerosis in males only (106) . Consistent with this, nettle extract altered lipid metabolism differently across sexes, with the activation of transcription factors that control lipid metabolism, and subsequent increase in HDL-cholesterol, specific to male mice (107) .…”

Section: Plant Bioactivessupporting

confidence: 56%

Sexual dimorphism in the context of nutrition and health

Pontifex,

Vauzour,

Muller

2023

Proc. Nutr. Soc.

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Diets and dietary constituents that we consume have a considerable impact on disease risk. Intriguingly these effects may be modulated to some extent by sex. Lack of female representation in nutritional studies as well as a lack of stratification by sex has and continues to limit our understanding of these sex × diet interactions. Here we provide an overview of the current and available literature describing how exposure to certain dietary patterns (Western-style diet, Mediterranean diet, vegetarian/vegan, ketogenic diet) and dietary constituents (dietary fibre, PUFA and plant bioactive) influences disease risk in a sex-specific manner. Interestingly, these sex differences appear to be highly disease-specific. The identification of such sex differences in response to diet stresses the importance of sex stratification in nutritional research.

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Section: Plant Bioactivessupporting

confidence: 56%