The Effects of Nicotine on the Incisive Teeth and Expression of Vimentin in Rats

Er, Faruk; Deveci, Engin; Kalkanlı, Sevgi; Deveci, B

doi:10.4067/s0717-95022013000200026

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…In addition, the action of nicotine and lipopolysaccharide on SIRT1 mRNA up-regulation in hGFs has an anti-inflammatory and pro-inflammatory effect 33 . Studies show that nicotine may alter periodontal cells directly via nAChRs, leading to pathophysiological effects and the development of tobacco-related diseases in these cells 34-36 .…”

Section: Resultsmentioning

confidence: 99%

Effect of tobacco on periodontal disease and oral cancer

Zhang¹,

He²,

He³

et al. 2019

Tob. Induc. Dis.

110

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INTRODUCTION Periodontal disease and oral cancer are common health hazards. Epidemiological investigations show that smoking, periodontal disease and oral cancer are closely related. Tobacco is one of the major risk factors for periodontitis and oral cancer. METHODS A systematic literature review was performed. To identify relevant studies, the following online databases were searched using specific keywords: PubMed, Web of Science and CNKI. RESULTS Tobacco not only possesses an addictive effect, but it aggravates periodontal disease by promoting the invasion of pathogenic bacteria, inhibiting autoimmune defense, aggravating the inflammatory reaction, and aggravating the loss of alveolar bone. According to current evidence, tobacco significantly aggravates the development and progression of periodontal disease and oral cancer, and periodontal disease may be related to the prevalence of oral cancer. CONCLUSIONS Clinicians should strongly recommend that smokers undertake a strategy to stop smoking to avoid the exacerbation of nicotine-related periodontal disease and to reduce the incidence of oral cancer.

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Section: Resultsmentioning

confidence: 99%

Effect of tobacco on periodontal disease and oral cancer

Zhang¹,

He²,

He³

et al. 2019

Tob. Induc. Dis.

110

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“…Cigarette smoke condensate has been reported to up-regulate MMP-1, MMP-8 and MMP-9 gene expression in vascular endothelial cells [34]. Er et al [13] found that fibroblast metabolism could be altered by nicotine action and intercellular matrix synthesis was affected. It also affects periodontal ligament fibroblasts and stimulates osteoclasts activity [19,42].…”

Section: Discussionmentioning

confidence: 99%

Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane

et al. 2018

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Nicotine is associated with increased incidence of periodontal disease and poor response to therapy. This article aimed at identifying the expression of Matrix metalloproteinases-2 (MMP2) and Vascular endothelial growth factor (VEGF) proteins on extracellular matrix, fibrous distribution and angiogenetic development in periodontitis caused by nicotine effects on periodontal membrane. In this experimental study, the groups were divided into nicotine and control groups. While the nicotine groups in rats (n=6) were administered 2mg/kg Nicotine sulphate for 28 days, the control group in rats (n=6) were only administered 1,5 ml physiologic saline solution subcutaneously for 28 days. Histological sections were prepared and immunohistochemically stained for MMP2 and VEGF. The sections were stained with Trichrome-Masson were observed under light microscope. VEGF and MMP2 immunoreactivity of periodontal gingiva and dentin was assessed by immunohistochemical staining. In conclusion, nicotine effect reduces Matrix metalloproteinases production and disrupt collagen synthesis and causes periodontitis. We observed that nicotine increases periodontitis by disrupting periodontal membrane and prevent tooth to anchor in dental alveoli by disrupting epithelial structure.

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