The effects of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring AA and alcohol-avoiding ANA rats

Kiianmaa, Kalervo; Tuomainen, Päivi; Makova, Natalia Z.; Seppä, Tiina; Mikkola, Janne; Piepponen, Petteri; Ahtee, Liisa; Hyytiä, Petri

doi:10.1016/s0014-2999(00)00759-7

Cited by 19 publications

(11 citation statements)

References 39 publications

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“…In another study, no clear effect of nicotine on locomotion was, however, found in adolescent rats, while similar doses in late adolescence and adulthood suppressed locomotion (Belluzzi et al, 2004). The lack of difference between the lines in adulthood in the acute effect of nicotine found here is in agreement with our previous study, where no difference was found between adult AA and ANA rats in nicotineinduced (0.5 mg ⁄ kg) locomor acitivity (Kiianmaa et al, 2000).…”

Section: Discussionsupporting

confidence: 92%

“…Besides differing in intake of ethanol, the AA rats consume more etonitazene and cocaine than ANA rats (Hyytiaä nd Sinclair, 1993), and the AAs show higher susceptibility to the behavioral and neurochemical effects of repeated administration of cocaine and morphine than ANAs (Honkanen et al, 1999;Mikkola et al, 2001Mikkola et al, , 2002Ojanen et al, 2003). The lines do not, however seem to differ in the sensitizing effects of nicotine (Kiianmaa et al, 2000).…”

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confidence: 99%

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Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Kemppainen

Hyytiä

Kiianmaa

2009

Alcoholism Clin & Exp Res

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These findings provide no or little support for the views that adolescent animals are more sensitive to the neurobehavioral effects of repeated exposure to nicotine and that exposure to nicotine in adolescence may contribute to enhanced vulnerability to ethanol abuse. Furthermore, genetic predisposition to high or low ethanol self-administration does not seem to be a factor that influences individual vulnerability to the neurobehavioral effects of repeated administration of nicotine.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Kemppainen

Hyytiä

Kiianmaa

2009

Alcoholism Clin & Exp Res

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“…Recent studies (Salminen and Ahtee, 2000;Kiianmaa et al, 2000) have shown that chronic intake of nicotine does not influence striatal and plasma HVA concentration in rodents suggesting only little influence of smoking status on the results of the present study. However, on the background of conflicting results of some prior studies revealing altered HVA concentrations caused by the intake of nicotine (Pietila et al, 1995;Geracioti et al, 1999), the issue should be investigated further in future studies.…”

Section: Discussionsupporting

confidence: 42%

Plasma Homovanillic Acid: A Significant Association with Alcoholism is Independent of a Functional Polymorphism of the Human Catechol-O-Methyltransferase Gene

Köhnke¹,

Wiatr²,

Kolb³

et al. 2002

Neuropsychopharmacol

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The central dopamine system seems to influence addictive disorders. Plasma homovanillic acid (HVA) is an indicator of central dopaminergic activity. In this study the hypothesis that plasma HVA is associated with alcoholism or with delirium tremens (DT) during alcohol withdrawal was tested. A functional genetic polymorphism of the enzyme catechol-O-methyltransferase (COMT) that participates in converting dopamine into its final metabolite HVA was investigated for an association with alcoholism or DT during alcohol withdrawal. In addition, a relation between the functional polymorphism of COMT and plasma HVA concentrations was studied. Plasma HVA concentrations and COMT genotypes were determined in 142 German alcoholics and 101 German healthy controls. Alcoholic patients were examined after a minimum of 3 weeks after cessation of drinking. Mean plasma HVA concentrations were significantly lower in alcoholic patients compared to healthy controls. A group of alcoholics with a history of DT during alcohol withdrawal (n ¼ 62) did not differ significantly in plasma HVA concentrations from alcoholics with a history of only mild withdrawal symptoms (n ¼ 67). The functional polymorphism of the human COMT gene was neither significantly associated with the diagnosis of alcoholism or DT during alcohol withdrawal nor with plasma HVA concentrations.

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“…Horizontal locomotion has been used to quantify genetic differences to nicotine-induced locomotor responses in various animal models with particular emphasis on mice and rats (Stohr et al, 1998;Cabib and Bonaventura, 1997;Murphy et al, 2001;Witkin and Goldberg, 1990;Hatchell and Collins, 1977;Schlatter and Battig, 1979;Battig et al, 1976;Kiianmaa et al, 2000). Such research has been based on the premise that differential sensitivity to nicotine-induced locomotor activity may be related to genotype and provide a possible model to prevent addictive smoking behavior in humans, including the age of initiation and extent of the activity.…”

Section: Introductionmentioning

confidence: 99%

Addiction and Dose Response: The Psychomotor Stimulant Theory of Addiction Reveals That Hormetic Dose Responses Are Dominant

Calabrese

2008

Critical Reviews in Toxicology

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In 1987 Wise and Bozarth proposed a psychomotor stimulant theory of addiction whose most consistent feature was enhanced forward (horizontal) locomotion. While controversial, the theory of Wise and Bozarth has had substantial impact on addiction behavior theory over the past two decades, being cited over 1,400 times. The present assessment places the theoretical formulation of Wise and Bozarth (1987) within a dose-response framework. This analysis demonstrates that the psychomotor stimulant effects of addictive drugs routinely display biphasic dose-response relationships that are consistent with the quantitative features of the hormetic dose-response model. This is the case, regardless of addictive agent, animal model, and experimental protocol employed. Not only do these findings suggest an important role for the hormetic dose response model in the assessment of addictive behaviors, they also further extend the generalizability of the hormesis dose-response model concept within the biomedical sciences.

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The effects of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring AA and alcohol-avoiding ANA rats

Cited by 19 publications

References 39 publications

Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Plasma Homovanillic Acid: A Significant Association with Alcoholism is Independent of a Functional Polymorphism of the Human Catechol-O-Methyltransferase Gene

Addiction and Dose Response: The Psychomotor Stimulant Theory of Addiction Reveals That Hormetic Dose Responses Are Dominant

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